Deep Learning Predictive Model for Detecting Human Influenza Virus Through Biological Sequences

Abstract

Swine influenza is a contagious disease which is generated by one of the swine influenza viruses. Any modification in protein will alter the biological activity and lead to illness. Obtaining appropriate information from virus protein sequence is an interesting research problem in bioinformatics. The aim of this research work is to develop deep neural network (DNN)-based virus identification model for detecting the virus accurately with the protein sequences using deep learning. Deep learning is gaining more importance because of its governance in terms of accuracy when the network trained with large amount of data. A corpus of 404 protein sequences associated with nine types of human influenza virus is collected for training the deep neural network and building the model. Various parameters of the DNN such as input layer, hidden layer and output layer are fine-tuned to improve the efficiency of the model. Sequential model is created for developing DNN classification model using Adam optimizer with Softmax and ReLu activation functions. It is observed that experiments of proposed human influenza virus identification model with DNN classifier give 80% of accuracy and outperform with other ensemble learning algorithms.