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Neoplastic Diseases in HIV/AIDS Patients

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Mucocutaneous Manifestations of HIV/AIDS

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Abstract

AIDS patients have a high incidence and mortality risk of tumors. AIDS-associated malignant tumors include AIDS-defining malignancies and non-AIDS-defining malignancies. AIDS-defining malignancies include non-Hodgkin’s lymphoma, Kaposi’s sarcoma, and cervical cancer. Non-AIDS-defining malignancies are composed of cancers of lung, liver, anal, skin and colorectal cancer or Hodgkin lymphoma. This chapter consists of a large number of cases on neoplastic diseases in HIV/AIDS patients, including Kaposi’s sarcoma, diffuse large B-cell lymphoma, Burkitt’s lymphoma, peripheral T-cell lymphoma, plasmablastic lymphoma, NK/T cell lymphoma, cervical cancer, basal cell carcinoma, squamous cell carcinoma, dermatofibrosarcoma protuberans, adult fibrosarcoma, and malignant pleomorphic adenoma.

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References

  1. Cooley TP. Non-AIDS-defining cancer in HIV-infected people. Hematol Oncol Clin North Am. 2003;17(3):889–99.

    Article  Google Scholar 

  2. Martel CD, Shiels MS, Franceschi S, et al. Cancers attributable to infections among adults with HIV in the United States. AIDS. 2015;29(16):2173–81.

    Article  Google Scholar 

  3. Rezza G, Andreoni M, Dorrucci M, et al. Risk of Kaposi’s sarcoma and other AIDS defining diseases in HIV-HHV-8 coinfected individuals. J Acquir Immune Defic Syndr. 1992;21(1):A10.

    Article  Google Scholar 

  4. d’Arminio Monforte A, Cozzi-Lepri A, et al. Risk of developing specific AIDS-defining illnesses in patients coinfected with HIV and hepatitis C virus with or without liver cirrhosis. Clin Infect Dis. 2009;49(4):612–22.

    Article  Google Scholar 

  5. Vanbaarle D, Miedema F, Hovenkamp E, et al. Dysfunctional Epstein-Barr virus (EBV)-specific CD8(+) T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma. Blood. 2001; https://doi.org/10.1182/blood.V98.1.146.

  6. Silva SRD, Oliveira DED. HIV, EBV and Kaposi’s: viral cooperation in the pathogenesis of human malignancies. Cancer Lett. 2011;305(2):175–85.

    Article  Google Scholar 

  7. Coghill AE, Shiels MS, Suneja G, et al. Elevated cancer-specific mortality among HIV-infected patients in the United States. J Clin Oncol. 2015;33(21):2376–83.

    Article  Google Scholar 

  8. Zucchetto A, Suligoi B, De Paoli A, et al. Excess mortality for non-AIDS-defining cancers among people with AIDS. Clin Infect Dis. 2010;51(9):1099–101.

    Google Scholar 

  9. Zucchetto A, Virdone S, Taborelli M, et al. Non-AIDS defining cancer mortality: emerging patterns in the late HAART era. J Acquir Immune Defic Syndr. 2016;73(2):190–6.

    Google Scholar 

  10. Marcus JL, Chao C, Leyden WA, et al. Survival among HIV-infected and HIV-uninfected individuals with common non-AIDS-defining cancers. Cancer Epidemiol Biomark Prev. 2015;24(8):1167–73.

    Article  Google Scholar 

  11. Riedel DJ, Cox ER, Stafford KA, et al. Clinical presentation and outcomes of prostate cancer in an urban cohort of predominantly African American, human immunodeficiency virus-infected patients. Urology. 2015;85:415–21.

    Article  Google Scholar 

  12. Feller L, Wood NH, Lemmer J. HIV-associated Kaposi sarcoma: pathogenic mechanisms. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2007;104(4):521–9.

    Article  Google Scholar 

  13. Kourí V, Martínez PA, Blanco O, et al. Simultaneous quantification of human herpesvirus 8 DNA by real time PCR in different tissues of HIV infected cuban patients with Kaposi’s sarcoma. Herpesviridae. 2010;1(1):3.

    Article  Google Scholar 

  14. Vanni T, Sprinz E, Machado MW, et al. Systemic treatment of AIDS-related Kaposi sarcoma: current status and perspectives. Cancer Treat Rev. 2006;32(6):445–55.

    Article  CAS  Google Scholar 

  15. Nagata N, Shimbo T, Yazaki H, et al. Predictive clinical factors in the diagnosis of gastrointestinal Kaposi’s sarcoma and its endoscopic severity. PLoS One. 2012;7(11):4696.

    Google Scholar 

  16. Cockerell CJ. Histopathological features of Kaposi’s sarcoma in HIV infected individuals. Cancer Surv. 1991;10:73–89.

    CAS  PubMed  Google Scholar 

  17. Krown SE. Highly active antiretroviral therapy in AIDS-associated Kaposi’s sarcoma: implications for the design of therapeutic trials in patients with advanced, symptomatic Kaposi’s sarcoma. J Clin Oncol. 2003;22(3):399–402.

    Article  Google Scholar 

  18. Nasti G, Martellotta F, Berretta M, et al. Impact of highly active antiretroviral therapy on the presenting features and outcome of patients with acquired immunodeficiency syndrome–related Kaposi sarcoma. Cancer. 2003;98(11):2440–6.

    Article  Google Scholar 

  19. Hoffmann C, RocKaposi’s Sarcomatroh JK. HIV. Hamburg: Medizin Fokus Verlag; 2010. p. 410–32.

    Google Scholar 

  20. Dal ML, Franceschi S. Epidemiology of non-Hodgkin lymphomas and other haemolymphopoietic neoplasms in people with AIDS. Lancet Oncol. 2003;4(2):110–9.

    Article  Google Scholar 

  21. Gobbi PG, Andrés JM, Ponzoni M. Hodgkin lymphoma. Crit Rev Oncol Hematol. 2013;85(2):216–37.

    Article  Google Scholar 

  22. Habermann TM. New developments in the management of diffuse large B-cell lymphoma. Hematology. 2012;17(Suppl 1):S93–7.

    Article  CAS  Google Scholar 

  23. Hong J, Kim SJ, Suh C, et al. Treatment outcomes of Rituximab Plus hyper-CVAD in Korean patients with sporadic Burkitt or Burkitt-like lymphoma: results of a multicenter analysis. Cancer Res Treatment. 2015;47(2):173–81.

    Article  CAS  Google Scholar 

  24. Chen WQ, Zheng RS, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115–32.

    Article  Google Scholar 

  25. Salopek KM, Jukić S, Babić D. Correlation of the HPV detection, protein expression and DNA content in cutaneous pre-invasive and invasive carcinoma among Croatian patients. Exp Mol Pathol. 2017;102(1):123–7.

    Article  CAS  Google Scholar 

  26. Bermudez A, Bhatla N, Leung E. Cancer of the cervix uteri. Int J Gynecol Obstet. 2015;131:S88. https://doi.org/10.1016/j.ijgo.2015.06.004.

    Article  Google Scholar 

  27. Dryden-Peterson S, Bvochora-Nsingo M, Suneja G, et al. HIV infection and survival among women with cervical cancer. J Clin Oncol. 2016;34(31):3749–57. https://doi.org/10.1200/JCO.2016.67.9613.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Robbins HA, Strickler HD, Massad LS. Cervical cancer screening intervals and management for women living with HIV: a risk bench marking approach. AIDS. 2017;31(7):1035.

    Article  Google Scholar 

  29. Kuflik AS, Janniger CK. Basal cell carcinoma. Cancer. 2015;89(5):1012–8.

    Google Scholar 

  30. Gilde K. Malignant tumors of the skin. Orv Hetil. 2007;147(48):2321–30.

    Google Scholar 

  31. Asgari MM, Ray GT, Quesenberry CP. Association of multiple primary skin cancers with human immunodeficiency virus infection, CD4 count, and viral load. JAMA Dermatol. 2017;153(9):892–6.

    Article  Google Scholar 

  32. Hausauer AK, Maurer T, Leslie KS, et al. Recurrence after treatment of cutaneous basal cell and squamous cell carcinomas in patients infected with human immunodeficiency virus. JAMA Dermatol. 2013;149(2):239–40.

    Article  Google Scholar 

  33. Vander Snoek EM, Vander Ende ME, Den Hollander JC, et al. Use of highly active antiretroviral therapy is associated with lower prevalence of anal intraepithelial neoplastic lesions and lower prevalence of human papillomavirus in HIV-infected men who have sex with men. Sex Transm Dis. 2012;39(7):495–500.

    Article  CAS  Google Scholar 

  34. Silverberg MJ, Leyden W, Warton EM, et al. HIV infection status, immunodeficiency, and the incidence of non-melanoma skin cancer. J Natl Cancer Inst. 2013;105(5):350–60.

    Article  CAS  Google Scholar 

  35. Hagensee ME, Clark RA, Cameron JE, et al. Human papillomavirus infection and disease in HIV-infected individuals. Am J Med Sci. 2004;328(1):57–63.

    Article  Google Scholar 

  36. Nguyen P, Vinchristian K, Ming ME. Aggressive squamous cell carcinomas in persons infected with the human immunodeficiency virus. Arch Dermatol. 2002;138(6):758–63.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, Kunming, China

    Tong-Yun Liu, Yu-Ye Li & Jue Qi

  2. Department of Radiation Oncology, First Affiliated Hospital of Kunming Medical University, Kunming, China

    Pei-Zhu Zhao

  3. Department of Obstetrics and Gynecology, First affiliated Hospital of Kunming Medical University, Kunming, China

    Hong-Yun Zhang

  4. Department of Infectious Diseases, Yunnan Provincial Infectious Disease Hospital, Yunnan AIDS Care Center, Kunming, China

    Hai-Yan Min

  5. Second Department of Medical Oncology, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming, China

    Run-Xiang Yang

  6. Department of Dermatology and Venereology, Beijing You’an Hospital, Capital Medical University, Beijing, China

    Xiao-Dan Wang

  7. Department of Dermatology and Venereology, Beijng Ditan Hospital, Capital Medical University, Beijing, China

    Yan Wu

  8. Department of Venereology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China

    Li-Hao Chen

  9. Department of Dermatopathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China

    Wei Zhang

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  1. Tong-Yun Liu
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  4. Hai-Yan Min
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  8. Xiao-Dan Wang
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  9. Yan Wu
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  10. Li-Hao Chen
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  11. Wei Zhang
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Editor information

Editors and Affiliations

  1. Department of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, Kunming, China

    Yu-Ye Li

  2. Department of General Surgery, NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China

    Kun-Hua Wang

  3. Department of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, Kunming, China

    Li He

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© 2020 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China

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Liu, TY. et al. (2020). Neoplastic Diseases in HIV/AIDS Patients. In: Li, YY., Wang, KH., He, L. (eds) Mucocutaneous Manifestations of HIV/AIDS. Springer, Singapore. https://doi.org/10.1007/978-981-15-5467-4_6

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  • DOI: https://doi.org/10.1007/978-981-15-5467-4_6

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-5466-7

  • Online ISBN: 978-981-15-5467-4

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