Skip to main content
SpringerLink
Log in

Ocular Cancer Stem Cells: Advances in Therapeutic Interventions

  • Chapter
  • First Online:
Cancer Stem Cells: New Horizons in Cancer Therapies

  • 521 Accesses

Abstract

Cancers affecting the eye are rare and can be either initiated in the eye, primary intraocular cancers, or invaded into the eye as a malignant tumor started elsewhere, secondary intraocular cancers. Melanoma and non-Hodgkin lymphoma in adults and retinoblastoma and medulloepithelioma in children are the most common intraocular cancers. Similar to other cancers, cancer stem cells are reported among retinoblastoma, lymphoma, and melanomas that can be malignant even though are very rare in occurrence. Here, we explore the cancers of the eye and cancer stem cells with the perspective of advanced therapeutic applications for vision and globe salvage.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Change history

  • 05 December 2020

    Correction to Chapter 7: Ocular Cancer Stem Cells: Advances in Therapeutic Interventions in the book titled Cancer Stem Cells: New Horizons in Cancer Therapies https://doi.org/10.1007/978-981-15-5120-8_7

References

  1. Dhamodaran K et al (2014) Ocular stem cells: a status update! Stem Cell Res Ther 5(2):56

    PubMed  PubMed Central  Google Scholar 

  2. Wicha MS, Liu S, Dontu G (2006) Cancer stem cells: an old idea—a paradigm shift. Cancer Res 66(4):1883–1890. discussion 1895-6

    CAS  PubMed  Google Scholar 

  3. Ajani JA et al (2015) Cancer stem cells: the promise and the potential. Semin Oncol 42:S3–S17

    CAS  PubMed  Google Scholar 

  4. Hall PA, Watt FM (1989) Stem cells: the generation and maintenance of cellular diversity. Development 106(4):619–633. PMID: 2562658.

    CAS  PubMed  Google Scholar 

  5. Potten CS, Loeffler M (1990) Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 110(4):1001–1020. PMID: 2100251.

    CAS  PubMed  Google Scholar 

  6. Morrison SJ, Weissman IL (1994) The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1(8):661–673. PMID: 7541305.

    CAS  PubMed  Google Scholar 

  7. Boulton M, Albon J (2004) Stem cells in the eye. Int J Biochem Cell Biol 36(4):643–657

    CAS  PubMed  Google Scholar 

  8. Hongxiang Hui YT, Hu M, Zhao X (2011) In: Gholamrezanezhad A (ed) Stem cells: general features and characteristics, stem cells in clinic and research. IntechOpen, London

    Google Scholar 

  9. Morrison SJ, Shah NM, Anderson DJ (1997) Regulatory mechanisms in stem cell biology. Cell 88(3):287–298

    CAS  PubMed  Google Scholar 

  10. Reya T et al (2001) Stem cells, cancer, and cancer stem cells. Nature 414(6859):105–111

    CAS  PubMed  Google Scholar 

  11. Li F et al (2007) Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res 17(1):3–14

    CAS  PubMed  Google Scholar 

  12. Osei-Bempong C, Figueiredo FC, Lako M (2013) The limbal epithelium of the eye—a review of limbal stem cell biology, disease and treatment. Bioessays 35(3):211–219

    CAS  PubMed  Google Scholar 

  13. Chen Z et al (2004) Characterization of putative stem cell phenotype in human limbal epithelia. Stem Cells 22(3):355–366

    PubMed  PubMed Central  Google Scholar 

  14. Khoshzaban A, Jafari E, Soleimani M, Tabatabaei SA, Nekoozadeh S et al (2018) Introduction of stem cells in ophthalmology. J Stem Cells Clin Pract 1(1):104

    Google Scholar 

  15. Du Y et al (2005) Multipotent stem cells in human corneal stroma. Stem Cells 23(9):1266–1275

    PubMed  PubMed Central  Google Scholar 

  16. Rosellini A et al (2007) Human conjunctival epithelial precursor cells and their progeny in 3D organotypic culture. Int J Dev Biol 51(8):739–743

    CAS  PubMed  Google Scholar 

  17. Arnhold S et al (2004) Iris pigment epithelial cells: a possible cell source for the future treatment of neurodegenerative diseases. Exp Neurol 187(2):410–417

    CAS  PubMed  Google Scholar 

  18. Xu H et al (2007) Characteristics of progenitor cells derived from adult ciliary body in mouse, rat, and human eyes. Invest Ophthalmol Vis Sci 48(4):1674–1682

    PubMed  Google Scholar 

  19. Tay CY et al (2012) Identification and characterization of mesenchymal stem cells derived from the trabecular meshwork of the human eye. Stem Cells Dev 21(9):1381–1390

    CAS  PubMed  Google Scholar 

  20. Du Y et al (2012) Multipotent stem cells from trabecular meshwork become phagocytic TM cells. Invest Ophthalmol Vis Sci 53(3):1566–1575

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Banin E et al (2006) Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cells. Stem Cells 24(2):246–257

    PubMed  Google Scholar 

  22. Tsai CL et al (2011) Identification of multipotent stem/progenitor cells in murine sclera. Invest Ophthalmol Vis Sci 52(8):5481–5487

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Chien MH et al (2012) Systemic human orbital fat-derived stem/stromal cell transplantation ameliorates acute inflammation in lipopolysaccharide-induced acute lung injury. Crit Care Med 40(4):1245–1253

    CAS  PubMed  Google Scholar 

  24. Kim N et al (2015) Cancer stem cell markers in eyelid sebaceous gland carcinoma: high expression of ALDH1, CD133, and ABCG2 correlates with poor prognosis. Invest Ophthalmol Vis Sci 56(3):1813–1819

    CAS  PubMed  Google Scholar 

  25. Deprez M, Uffer S (2009) Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature. Am J Dermatopathol 31(3):256–262

    PubMed  Google Scholar 

  26. Pe’er J (2016) Pathology of eyelid tumors. Indian J Ophthalmol 64(3):177–190

    PubMed  PubMed Central  Google Scholar 

  27. Yu SS et al (2018) A retrospective study of 2228 cases with eyelid tumors. Int J Ophthalmol 11(11):1835–1841

    PubMed  PubMed Central  Google Scholar 

  28. Karan S et al (2016) Clinicopathological study of eye lid tumours in Hyderabad—a review of 57 cases. J Med Allied Sci 6:1

    Google Scholar 

  29. Kersten RC et al (1997) Accuracy of clinical diagnosis of cutaneous eyelid lesions. Ophthalmology 104(3):479–484

    CAS  PubMed  Google Scholar 

  30. Weinstein GW, Goldman JN (1963) Metastatic adenocarcinoma of the breast masquerading as Chalazion*. Am J Ophthalmol 56(6):960–963

    CAS  PubMed  Google Scholar 

  31. Riley FC (1970) Metastatic tumors of the eyelids. Am J Ophthalmol 69(2):259–264

    CAS  PubMed  Google Scholar 

  32. Hogan MJ, Zimmerman LE, American Academy of Ophthalmology and Otolaryngology (1962) Otolaryngology, ophthalmic pathology, an atlas and textbook. Saunders, Philadelphia

    Google Scholar 

  33. Benson JR, Rovere GQ d, Nasiri N (2001) Eyelid metastasis. Lancet 358(9290):1370–1371

    CAS  PubMed  Google Scholar 

  34. Hood CI, Font RL, Zimmerman LE (1973) Metastatic mammary carcinoma in the eyelid with histiocytoid appearance. Cancer 31(4):793–800

    CAS  PubMed  Google Scholar 

  35. Kanitakis J, Faure M, Claudy A (2001) Clinical picture: eyelid metastasis. Lancet 358(9275):33

    CAS  PubMed  Google Scholar 

  36. Mehta KS et al (2012) Metastatic basal cell carcinoma: a biological continuum of basal cell carcinoma? Case Rep Dermatol Med 2012:4

    Google Scholar 

  37. Faustina M et al (2004) Patterns of regional and distant metastasis in patients with eyelid and periocular squamous cell carcinoma. Ophthalmology 111(10):1930–1932

    PubMed  Google Scholar 

  38. Shields CL et al (2004) Clinical survey of 1643 melanocytic and nonmelanocytic conjunctival tumors. Ophthalmology 111(9):1747–1754

    PubMed  Google Scholar 

  39. Emmanuel B et al (2012) Incidence of squamous-cell carcinoma of the conjunctiva and other eye cancers in the NIH-AARP Diet and Health Study. Ecancermedicalscience 6:254–254

    CAS  PubMed  PubMed Central  Google Scholar 

  40. Shields CL et al (2017) Conjunctival tumors: review of clinical features, risks, biomarkers, and outcomes—the 2017 J. Donald M. Gass Lecture. Asia Pac J Ophthalmol (Phila) 6(2):109–120

    Google Scholar 

  41. Maggs DJ (2008) Chapter 10—cornea and sclera. In: Maggs DJ, Miller PE, Ofri R (eds) Slatter’s fundamentals of veterinary ophthalmology, 4th edn. W.B. Saunders, Saint Louis, pp 175–202

    Google Scholar 

  42. Ofri R (2008) Chapter 2—Development and Congenital Abnormalities**The author wishes to acknowledge the contribution of Dr. Robert Barishak, and to thank him for his input throughout the years and to this chapter. In: Maggs DJ, Miller PE, Ofri R (eds) Slatter’s fundamentals of veterinary ophthalmology, 4th edn. W.B. Saunders, Saint Louis, pp 20–32

    Google Scholar 

  43. Shields CL, Shields JA (2004) Tumors of the conjunctiva and cornea. Surv Ophthalmol 49(1):3–24

    PubMed  Google Scholar 

  44. Othman IS (2009) Ocular surface tumors. Oman J Ophthalmol 2(1):3–14

    PubMed  PubMed Central  Google Scholar 

  45. Freeman RG, Knox JM (1964) Ultraviolet-induced corneal tumors in different species and strains of animals. J Invest Dermatol 43:431–436

    CAS  PubMed  Google Scholar 

  46. Sabourin CLK et al (1993) Expression of fibroblast growth factors in ultraviolet radiation—induced corneal tumors and corneal tumor cell lines from Monodelphis domestica. Mol Carcinog 7(3):197–205

    CAS  PubMed  Google Scholar 

  47. Kiratli H et al (1996) Metastatic tumours to the conjunctiva: report of 10 cases. Br J Ophthalmol 80(1):5–8

    CAS  PubMed  PubMed Central  Google Scholar 

  48. Shields CL et al (2011) Conjunctival melanoma: outcomes based on tumor origin in 382 consecutive cases. Ophthalmology 118(2):389–395.e2

    PubMed  Google Scholar 

  49. Shields CL et al (2000) Conjunctival melanoma: risk factors for recurrence, exenteration, metastasis, and death in 150 consecutive patients. Arch Ophthalmol 118(11):1497–1507

    CAS  PubMed  Google Scholar 

  50. Iliff WJ, Marback R, Green WR (1975) Invasive squamous cell carcinoma of the conjunctiva. Arch Ophthalmol 93(2):119–122

    CAS  PubMed  Google Scholar 

  51. Goldberg RA, Rootman J (1990) Clinical characteristics of metastatic orbital tumors. Ophthalmology 97(5):620–624

    CAS  PubMed  Google Scholar 

  52. Shields JA, Shields CL, Scartozzi R (2004) Survey of 1264 patients with orbital tumors and simulating lesions: the 2002 Montgomery Lecture, part 1. Ophthalmology 111(5):997–1008

    PubMed  Google Scholar 

  53. Selva D et al (2004) Primary bone tumors of the orbit. Surv Ophthalmol 49(3):328–342

    PubMed  Google Scholar 

  54. Blandford A, Perry J (2019) Classification of orbital tumors. In: Clinical ophthalmic oncology, pp 9–15

    Google Scholar 

  55. Nabavi, C.B., J.D. Perry, and J.A. Foster. Orbital tumors: differential diagnosis in adults. 2019

    Google Scholar 

  56. Goldberg RA, Rootman J, Cline RA (1990) Tumors metastatic to the orbit: a changing picture. Surv Ophthalmol 35(1):1–24

    CAS  PubMed  Google Scholar 

  57. Albert DM, Rubenstein RA, Scheie HG (1967) Tumor metastasis to the eye: part I. incidence in 213 adult patients with generalized malignancy. Am J Ophthalmol 63(4):723–726

    CAS  PubMed  Google Scholar 

  58. Albert DM, Rubenstein RA, Scheie HG (1967) Tumor metastasis to the eye: part II. Clinical study in infants and children. Am J Ophthalmol 63(4):727–732

    CAS  PubMed  Google Scholar 

  59. Kiratli H (2016) Intraocular metastases. S. Karger AG, Basel

    Google Scholar 

  60. Konstantinidis L, Damato B (2017) Intraocular metastases—a review. Asia Pac J Ophthalmol 6(2):208–214

    Google Scholar 

  61. Gunalp I, Gunduz K (1995) Metastatic orbital tumors. Jpn J Ophthalmol 39(1):65–70

    CAS  PubMed  Google Scholar 

  62. Shields CL et al (2001) Factors associated with elevated intraocular pressure in eyes with iris melanoma. Br J Ophthalmol 85(6):666–669

    CAS  PubMed  PubMed Central  Google Scholar 

  63. Gragoudas E et al (2002) Evidence-based estimates of outcome in patients irradiated for intraocular melanoma. Arch Ophthalmol 120(12):1665–1671

    PubMed  Google Scholar 

  64. Aerts I et al (2006) Retinoblastoma. Orphanet J Rare Dis 1:31

    PubMed  PubMed Central  Google Scholar 

  65. Dimaras H et al (2015) Retinoblastoma. Nat Rev Dis Primers 1:15021

    PubMed  PubMed Central  Google Scholar 

  66. Damato B (2006) Vasoproliferative retinal tumour. Br J Ophthalmol 90(4):399–400

    CAS  PubMed  PubMed Central  Google Scholar 

  67. Dollfus H et al (2002) Retinal hemangioblastoma in von Hippel-Lindau disease: a clinical and molecular study. Invest Ophthalmol Vis Sci 43(9):3067–3074

    PubMed  Google Scholar 

  68. Tucker MA et al (1985) Sunlight exposure as risk factor for intraocular malignant melanoma. N Engl J Med 313(13):789–792

    CAS  PubMed  Google Scholar 

  69. Arepalli S, Kaliki S, Shields CL (2015) Choroidal metastases: origin, features, and therapy. Indian J Ophthalmol 63(2):122–127

    PubMed  PubMed Central  Google Scholar 

  70. Shields CL et al (1997) Survey of 520 eyes with uveal metastases. Ophthalmology 104(8):1265–1276

    CAS  PubMed  Google Scholar 

  71. Nichols EE, Richmond A, Daniels AB (2016) Tumor characteristics, genetics, management, and the risk of metastasis in uveal melanoma. Semin Ophthalmol 31(4):304–309

    PubMed  PubMed Central  Google Scholar 

  72. Shields CL et al (1994) Optic nerve invasion of retinoblastoma. Metastatic potential and clinical risk factors. Cancer 73(3):692–698

    CAS  PubMed  Google Scholar 

  73. Shields CL (2019) Retinoblastoma. In: Rojanaporn D (ed) Ocular oncology. Retina atlas. Springer, Singapore

    Google Scholar 

  74. Taipale J, Beachy PA (2001) The Hedgehog and Wnt signalling pathways in cancer. Nature 411(6835):349–354

    CAS  PubMed  Google Scholar 

  75. Zhang CL et al (2017) Stem cells in cancer therapy: opportunities and challenges. Oncotarget 8(43):75756–75766

    PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Prof. Brien Holden Eye Research Center, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Banjara Hills, Hyderabad, India

    Upasna Upadhyay, Raaghav Sen & Jaganmohan R. Jangamreddy

  2. Operation Eyesight Universal Institute for Eye Cancer, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Banjara Hills, Hyderabad, India

    Upasna Upadhyay, Raaghav Sen, Swathi Kaliki & Jaganmohan R. Jangamreddy

  3. The Cornea Institute, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Banjara Hills, Hyderabad, India

    Jaganmohan R. Jangamreddy

Authors
  1. Upasna Upadhyay
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Raaghav Sen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Swathi Kaliki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jaganmohan R. Jangamreddy
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Chennai, Tamil Nadu, India

    Surajit Pathak

  2. Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Chennai, Tamil Nadu, India

    Antara Banerjee

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Upadhyay, U., Sen, R., Kaliki, S., Jangamreddy, J.R. (2020). Ocular Cancer Stem Cells: Advances in Therapeutic Interventions. In: Pathak, S., Banerjee, A. (eds) Cancer Stem Cells: New Horizons in Cancer Therapies. Springer, Singapore. https://doi.org/10.1007/978-981-15-5120-8_7

Download citation

Publish with us

Policies and ethics

Search

Navigation