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Marine Nutraceuticals

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Marine Niche: Applications in Pharmaceutical Sciences

Abstract

In modern era nutraceuticals have received considerable interest to cure or prevention of various diseases. Marine nutraceuticals are the products or substances which are obtained from the marine sources such as fish, prawn, sponges, and many other marine organisms. Nutraceuticals comprise of various proteins, peptides, carbohydrates, essential minerals, bioactive peptides, vitamins, enzymes, phenolic phlorotannins, and polyunsaturated fatty acids (PUFA). Many of these are also used as therapeutic agents to cure diseases. Marine sources are well-recognized for biologically active materials by their numerous potentials to be used as nutraceuticals. Moreover, these functional foods are also used to enhance human lifestyles, in that marine-derived nutraceuticals are considered a natural means of achieving healthy lifestyles. Fish and shellfish are considered the main sources of marine-based nutraceuticals. Fish bone is a worthy source of calcium, while the fish membrane and frame are a potent material used for isolation of bioactive peptides. In addition, the global market for nutraceuticals is growing in comparison to conventional therapy, including in countries such as Western Asia, East Asia, South Asia, Southeast Asia, and Oceania and Japan, Europe, China, India, and the United States.

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References

  • Ackman R (1995) Fish and fishery products-composition and nutritive value of fish and shellfish. Lipids 30:132–134

    Google Scholar 

  • Alam M, Thomson RH (1998) Handbook of natural products from marine invertebrates. CRC Press

    Google Scholar 

  • Appleyard VC, Unkles SE, Legg M, Kinghorn JR (1995) Secondary metabolite production in filamentous fungi displayed. Mol Gen Genet MGG 247(3):338–342

    Article  CAS  PubMed  Google Scholar 

  • Béné C, Neiland AE (2003) Fisheries development issues and their impacts on the livelihoods of fishing communities in West-Africa: an overview. J Food Agric Environ 1(1):128–134

    Google Scholar 

  • Benkendorff K (2010) Molluscan biological and chemical diversity: secondary metabolites and medicinal resources produced by marine molluscs. Biol Rev 85(4):757–775

    PubMed  Google Scholar 

  • Bergé JP, Barnathan G (2005) Fatty acids from lipids of marine organisms: molecular biodiversity, roles as biomarkers, biologically active compounds, and economical aspects. In: Marine biotechnology I. Springer, Berlin/Heidelberg, pp 49–125

    Chapter  Google Scholar 

  • Blunt JW, Copp BR, Munro MH, Northcote PT, Prinsep MR (2003) Marine natural products. Nat Prod Rep 20(1):1–48

    Article  CAS  PubMed  Google Scholar 

  • Børresen T (2009) Seafood for improved health and wellbeing. Food Technol 63(1):88

    Google Scholar 

  • Brownlee IA, Allen A, Pearson JP, Dettmar PW, Havler ME, Atherton MR, Onsøyen E (2005) Alginate as a source of dietary fiber. Crit Rev Food Sci Nutr 45(6):497–510

    Article  CAS  PubMed  Google Scholar 

  • Cambie RC, Ferguson LR (2003) Potential functional foods in the traditional Maori diet. Mutat Res/Fundam Mol Mech Mutagen 523:109–117

    Article  CAS  Google Scholar 

  • Caner C, Vergano PJ, Wiles JL (1998) Chitosan film mechanical and permeation properties as affected by acid, plasticizer, and storage. J Food Sci 63(6):1049–1053

    Article  CAS  Google Scholar 

  • Capon RJ, Rooney F, Murray LM, Collins E, Sim AT, Rostas JA, Butler MS, Carroll AR (1998) Dragmacidins: new protein phosphatase inhibitors from a southern Australian deep-water marine sponge, Spongosorites sp. J Nat Prod 61(5):660–662

    Article  CAS  PubMed  Google Scholar 

  • Christ T, Wüst M, Matthes J, Jänchen M, Jürgens S, Herzig S, Wettwer E, Dobrev D, Matschke K, Mebs D, Ravens U (2004) An aqueous extract of the marine sponge Ectyoplasia ferox stimulates L-type Ca 2+−current by direct interaction with the Ca v 1.2 subunit. Naunyn Schmiedeberg’s Arch Pharmacol 370(6):474–483

    Article  CAS  Google Scholar 

  • Clarkson PM, Rawson ES (1999) Nutritional supplements to increase muscle mass. Crit Rev Food Sci Nutr 39(4):317–328

    Article  CAS  PubMed  Google Scholar 

  • Davidson BS (1995) New dimensions in natural products research: cultured marine microorganisms. Curr Opin Biotechnol 6(3):284–291

    Article  CAS  Google Scholar 

  • DeFelice SL (1995) The nutraceutical revolution: its impact on food industry R&D. Trends Food Sci Technol 6(2):59–61

    Article  CAS  Google Scholar 

  • Dyerberg J, Bang HO, Hjørne N (1975) Fatty acid composition of the plasma lipids in Greenland Eskimos. Am J Clin Nutr 28(9):958–966

    Article  CAS  PubMed  Google Scholar 

  • Erdmann K, Cheung BW, Schröder H (2008) The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease. J Nutr Biochem 19(10):643–654

    Article  CAS  PubMed  Google Scholar 

  • Fenical W (1993) Chemical studies of marine bacteria: developing a new resource. Chem Rev 93(5):1673–1683

    Article  CAS  Google Scholar 

  • Fitton JH, Irhimeh MR, Teas J, Barrow C, Shahidi F (2008) Marine algae and polysaccharides with therapeutic applications. Mar Nutraceut Funct Foods:345–366

    Google Scholar 

  • Fsulkner DJ (2000) Highlights of marine natural products chemistry (1972-1999). Nat Prod Rep 17(1):1–6

    Article  Google Scholar 

  • Garg ML, Wood LG, Singh H, Moughan PJ (2006) Means of delivering recommended levels of long chain n-3 polyunsaturated fatty acids in human diets. J Food Sci 71(5):R66–R71

    Article  CAS  Google Scholar 

  • Graham IA, Cirpus P, Rein D, Napier JA (2004) The use of very long chain polyunsaturated fatty acids to ameliorate metabolic syndrome: transgenic plants as an alternative sustainable source to fish oils. Nutr Bull 29(3):228–233

    Article  Google Scholar 

  • Haefner B (2003) Drugs from the deep: marine natural products as drug candidates. Drug Discov Today 8(12):536–544

    Article  CAS  PubMed  Google Scholar 

  • Han H, Yi YH, Li L, Wang XH, Liu BS, Sun P, Pan MX (2007) A new triterpene glycoside from sea cucumber Holothuria leucospilota. Chin Chem Lett 18(2):161–164

    Article  CAS  Google Scholar 

  • Haug T, Kjuul AK, Styrvold OB, Sandsdalen E, Olsen ØM, Stensvåg K (2002) Antibacterial activity in Strongylocentrotus droebachiensis (Echinoidea), Cucumaria frondosa (Holothuroidea), and Asterias rubens (Asteroidea). J Invertebr Pathol 81(2):94–102

    Article  CAS  PubMed  Google Scholar 

  • Hernández-Herrero MM, Roig-Sagués AX, López-Sabater EI, Rodríguez-Jerez JJ, Mora-Ventura MT (2000) SDS-PAGE of salted anchovies (Engraulis encrasicholus L) during the ripening process. Eur Food Res Technol 212(1):26–30

    Article  Google Scholar 

  • Hill RT, Fenical W (2010) Pharmaceuticals from marine natural products: surge or ebb? Curr Opin Biotechnol 21:777–779

    Article  CAS  PubMed  Google Scholar 

  • Huei CR, Hwa HD (1996) Effect of molecular weight of chitosan with the same degree of deacetylation on the thermal, mechanical, and permeability properties of the prepared membrane. Carbohydr Polym 29(4):353–358

    Article  Google Scholar 

  • Hwang KT, Rhim JW, Park HJ (1997) Effects of ${\kappa}-carrageenan $-based film packaging on moisture loss and lipid oxidation of mackerel mince. Korean J Food Sci Technol 29(2):390–393

    Google Scholar 

  • Jo KS, Park YH (1985) Studies on the organic acids composition in shellfishes 1. Nonvolatile organic acids composition of top shell, hard clam, abalone and their boiled-dried products. Korean J Fish Aquatic Sci 18(3):227–234

    CAS  Google Scholar 

  • Kanazawa A (2001) Sterols in marine invertebrates. Fish Sci 67(6):997–1007

    Article  Google Scholar 

  • Kim SK (2012) Past, present, and future of marine pharmacognosy. In: Marine pharmacognosy. CRC Press

    Google Scholar 

  • Kim SK, Mendis E (2006) Bioactive compounds from marine processing byproducts–a review. Food Res Int 39(4):383–393

    Article  CAS  Google Scholar 

  • Kim SK, Wijesekara I (2010) Development and biological activities of marine-derived bioactive peptides: a review. J Funct Foods 2(1):1–9

    Article  CAS  Google Scholar 

  • Kim HL, Kang SG, Kim IC, Kim SJ, Kim DW, Ma SJ, Gao T, Li H, Kim MJ, Lee TH, Ham KS (2006) In vitro anti-hypertensive, antioxidant and anticoagulant activities of extracts from Haliotis discus hannai. J Korean Soc Food Sci Nutr 35(7):835–840

    Article  Google Scholar 

  • Kim HL, Kim SJ, Kim DW, Ma SJ, Gao T, Li H, Lee TH, Kim IC, Ham KS, Kang SG (2007a) The Abanones, Haliotis discus hannai, exhibit potential anticoagulant activity in Normal Sprague Dawley rats. Korean J Food Preserv 14(4):431–437

    Google Scholar 

  • Kim SK, Mendis E, Shahidi F (2007b) Marine fisheries by-products as potential nutraceuticals: an overview. Mar Nutraceut Funct Foods 13:1–23

    Google Scholar 

  • Kumar R, Chaturvedi AK, Shukla PK, Lakshmi V (2007) Antifungal activity in triterpene glycosides from the sea cucumber Actinopyga lecanora. Bioorg Med Chem Lett 17(15):4387–4391

    Article  CAS  PubMed  Google Scholar 

  • Larsen R, Eilertsen KE, Elvevoll EO (2011) Health benefits of marine foods and ingredients. Biotechnol Adv 29(5):508–518

    Article  CAS  PubMed  Google Scholar 

  • Lee JY, Park HJ, Lee CY, Choi WY (2003) Extending shelf-life of minimally processed apples with edible coatings and antibrowning agents. LWT-Food Sci Technol 36(3):323–329

    Article  CAS  Google Scholar 

  • Lopez-Rubio A, Gavara R, Lagaron JM (2006) Bioactive packaging: turning foods into healthier foods through biomaterials. Trends Food Sci Technol 17(10):567–575

    Article  CAS  Google Scholar 

  • Mamelona J, Pelletier E, Girard-Lalancette K, Legault J, Karboune S, Kermasha S (2007) Quantification of phenolic contents and antioxidant capacity of Atlantic Sea cucumber, Cucumaria frondosa. Food Chem 104(3):1040–1047

    Article  CAS  Google Scholar 

  • Martin RE (1982) Chemistry & biochemistry of marine food products. Avi Pub. Co., Westport

    Google Scholar 

  • Meisel H (1997) Biochemical properties of bioactive peptides derived from milk proteins: potential nutraceuticals for food and pharmaceutical applications. Livest Prod Sci 50(1–2):125–138

    Article  Google Scholar 

  • Messersmith PB (2007) Adhesive polymers inspired by marine glue proteins. In: Abstracts of papers of the American Chemical Society, vol 233. AMER Chemical SOC, Washington, DC

    Google Scholar 

  • Monahan J, Wilker JJ (2004) Cross-linking the protein precursor of marine mussel adhesives: bulk measurements and reagents for curing. Langmuir 20(9):3724–3729

    Article  CAS  PubMed  Google Scholar 

  • Mourão PA, Boisson-Vidal C, Tapon-Bretaudière J, Drouet B, Bros A, Fischer AM (2001) Inactivation of thrombin by a fucosylated chondroitin sulfate from echinoderm. Thromb Res 102(2):167–176

    Article  PubMed  Google Scholar 

  • Murray AP, Muniaı́n C, Seldes AM, Maier MS (2001) Patagonicoside A: a novel antifungal disulfated triterpene glycoside from the sea cucumber Psolus patagonicus. Tetrahedron 57(47):9563–9568

    Article  CAS  Google Scholar 

  • Nadarajah K, Prinyawiwatkul W, No HK, Sathivel S, Xu Z (2006) Sorption behavior of crawfish chitosan films as affected by chitosan extraction processes and solvent types. J Food Sci 71(2):E33–E39

    Article  CAS  Google Scholar 

  • Nettleton JA, Katz R (2005) N-3 long-chain polyunsaturated fatty acids in type 2 diabetes: a review. J Am Diet Assoc 105(3):428–440

    Article  CAS  PubMed  Google Scholar 

  • Ngo DH, Wijesekara I, Vo TS, Van Ta Q, Kim SK (2011) Marine food-derived functional ingredients as potential antioxidants in the food industry: an overview. Food Res Int 44(2):523–529

    Article  CAS  Google Scholar 

  • Park PJ, Jung WK, Nam KS, Shahidi F, Kim SK (2001) Purification and characterization of antioxidative peptides from protein hydrolysate of lecithin-free egg yolk. J Am Oil Chem Soc 78(6):651–656

    Article  CAS  Google Scholar 

  • Paulo A, Mourao S, Izaias GB (1987) Highly acidic glycans from sea cucumbers-isolation and fractionation of fucose-rich sulfated polysaccharides from the body wall of ludwigothurea grisea. Eur J Biochem 166:639–645

    Article  Google Scholar 

  • Pietra F (1990) A secret world. In: Natural products of marine life. Birkhäuser, Basel, pp 232–234

    Google Scholar 

  • Prashanth KH, Tharanathan RN (2007) Chitin/chitosan: modifications and their unlimited application potential—an overview. Trends Food Sci Technol 18(3):117–131

    Article  CAS  Google Scholar 

  • Proksch P, Edrada R, Ebel R (2002) Drugs from the seas–current status and microbiological implications. Appl Microbiol Biotechnol 59(2–3):125–134

    CAS  PubMed  Google Scholar 

  • Rhim JW, Ng PK (2007) Natural biopolymer-based nanocomposite films for packaging applications. Crit Rev Food Sci Nutr 47(4):411–433

    Article  CAS  PubMed  Google Scholar 

  • Rhim JW, Hwang KT, Park HJ, Kang SG, Jung ST (1998) Lipid penetration characteristics of carrageenan-based edible films. Korean J Food Sci Technol 30(2):379–384

    Google Scholar 

  • Saiga AI, Tanabe S, Nishimura T (2003) Antioxidant activity of peptides obtained from porcine myofibrillar proteins by protease treatment. J Agric Food Chem 51(12):3661–3667

    Article  CAS  PubMed  Google Scholar 

  • Schmidl MK (1993) Food products for medical purposes. Trends Food Sci Technol 4(6):163–168

    Article  Google Scholar 

  • Seymour TA, Li SJ, Morrissey MT (1996) Characterization of a natural antioxidant from shrimp shell waste. J Agric Food Chem 44(3):682–685

    Article  CAS  Google Scholar 

  • Shahidi F, Zhong Y (2008) Bioactive peptides. J AOAC Int 91(4):914–931

    Article  CAS  PubMed  Google Scholar 

  • Shanmugam M, Ramavat BK, Mody KH, Oza RM, Tewari A (2001) Distribution of heparinoid-active sulphated polysaccharides in some Indian marine green algae. Indian J Mar Sci 30:222–227

    Google Scholar 

  • Silva JJ, Chamul RS (2000) Composition of marine and freshwater finfish and shellfish species and their products. In: Marine and freshwater products handbook, vol 4. Technomic Pub. Co., Lancaster, pp 31–46

    Google Scholar 

  • Srinivasa PC, Tharanathan RN (2007) Chitin/chitosan—safe, ecofriendly packaging materials with multiple potential uses. Food Rev Int 23(1):53–72

    Article  CAS  Google Scholar 

  • Thorpe JP, Solé-Cava AM, Watts PC (2000) Exploited marine invertebrates: genetics and fisheries. In: Marine genetics. Springer, Dordrecht, pp 165–184

    Chapter  Google Scholar 

  • Trono GC (1999) Diversity of the seaweed flora of the Philippines and its utilization. Hydrobiologia 398:1–6

    Article  Google Scholar 

  • Venugopal V (2005) Nutritional value and processing effects. In: Seafood processing: adding value through quick freezing, retortable packaging, and cook-chilling. CRC, Boca Raton, pp 425–446

    Chapter  Google Scholar 

  • Venugopal V (2008) Marine products for healthcare: functional and bioactive nutraceutical compounds from the ocean. CRC Press, Boca Raton

    Book  Google Scholar 

  • Venugopal V, Shahidi F (1996) Structure and composition of fish muscle. Food Rev Int 12(2):175–197

    Article  Google Scholar 

  • Voultsiadou E (2010) Therapeutic properties and uses of marine invertebrates in the ancient Greek world and early Byzantium. J Ethnopharmacol 130(2):237–247

    Article  PubMed  Google Scholar 

  • Vrieling EG, Beelen TP, van Santen RA, Gieskes WW (1999) Diatom silicon biomineralization as an inspirational source of new approaches to silica production. In: Progress in industrial microbiology, vol 35. Elsevier, Amsterdam, pp 39–51

    Google Scholar 

  • Walton JD (2000) Horizontal gene transfer and the evolution of secondary metabolite gene clusters in fungi: an hypothesis. Fungal Genet Biol 30(3):167–171

    Article  CAS  PubMed  Google Scholar 

  • Wijesekara I, Kim SK (2010) Angiotensin-I-converting enzyme (ACE) inhibitors from marine resources: prospects in the pharmaceutical industry. Mar Drugs 8(4):1080–1093

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wijesekara I, Yoon NY, Kim SK (2010) Phlorotannins from Ecklonia cava (Phaeophyceae): biological activities and potential health benefits. Biofactors 36(6):408–414

    Article  CAS  PubMed  Google Scholar 

  • Wijesekara I, Pangestuti R, Kim SK (2011) Biological activities and potential health benefits of sulfated polysaccharides derived from marine algae. Carbohydr Polym 84(1):14–21

    Article  CAS  Google Scholar 

  • Wu Y, Rhim JW, Weller CL, Hamouz F, Cuppett S, Schnepf M (2000) Moisture loss and lipid oxidation for precooked beef patties stored in edible coatings and films. J Food Sci 65(2):300–304

    Article  CAS  Google Scholar 

  • Yoneda C, Hirayama Y, Nakaya M, Matsubara Y, Irie S, Hatae K, Watabe S (1999) The occurrence of two types of collagen proα-chain in the abalone Haliotis discus muscle. Eur J Biochem 261(3):714–721

    Article  CAS  PubMed  Google Scholar 

  • Yoo MJ, Chung HJ (2007) Optimal manufacturing condition and quality properties of the drinking extract of disk abalone. J Korean Soc Food Cult 22(6):827–832

    Google Scholar 

  • Yuan YV (2007) Antioxidants from edible seaweeds. In: ACS symposium series 2007, vol 956. Oxford University Press, Oxford, pp 268–301

    Google Scholar 

  • Zhang C, Ruan Y, Kim SK (2013) Biological activities of marine-derived bioactive peptides. Mar Biomater: Charact Isolat Appl 11:405

    Article  Google Scholar 

  • Zhou DY, Tong LE, ZHU BW, WU HT, Qin LE, Tan HU, Murata Y (2012) Extraction of lipid from abalone (Haliotis discus hannai Ino) gonad by supercritical carbon dioxide and enzyme-assisted organic solvent methods. J Food Process Preserv 36(2):126–132

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, MP, India

    Ramakant Joshi, Navneet Garud & Wasim Akram

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  1. Ramakant Joshi
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  2. Navneet Garud
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  3. Wasim Akram
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Editors and Affiliations

  1. Department of Science & Technology, Gujarat Biotechnology Research Centre (GBRC), Gandhinagar, Gujarat, India

    Neelam M Nathani

  2. Department of Science & Technology, Gujarat Biotechnology Research Centre (GBRC), Gandhinagar, Gujarat, India

    Chandrashekar Mootapally

  3. Department of Life Sciences, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, Gujarat, India

    Indra R. Gadhvi

  4. Department of Botany, Gujarat University, Ahmedabad, Gujarat, India

    Bharat Maitreya

  5. Department of Science & Technology, Gujarat Biotechnology Research Centre (GBRC), Gandhinagar, Gujarat, India

    Chaitanya G. Joshi

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Joshi, R., Garud, N., Akram, W. (2020). Marine Nutraceuticals. In: Nathani, N.M., Mootapally, C., Gadhvi, I.R., Maitreya, B., Joshi, C.G. (eds) Marine Niche: Applications in Pharmaceutical Sciences . Springer, Singapore. https://doi.org/10.1007/978-981-15-5017-1_3

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