Abstract
Marine ecology consists of major forms of life that exist on the earth. Approximately 230,000 marine species are estimated according to the World Register of Marine Species. Marine flora and fauna are tremendously valuable oceanic resources, which contribute to the major part of the oceanic biomass. They are taxonomically diverse, biologically potent, productive, and chemically inimitable in nature. The marine flora contain medicinally useful metabolites in abundance that include polyphenols, alkaloids, and sulfated polysaccharides. It has shown great role in pharmacological properties against cancer, microbial pathogenesis, malaria, viral diseases, inflammation, and diabetes. The phytochemicals possibly activate macrophages, reduce oxidative stressĀ and thus help in immunomodulation. Though marine niche has rich phytochemical diversity, yet it is considered majorly untapped or unexplored. Therefore, a vast number of new biomolecules such as enzymes, polymers, and osmolytes from the marine biotic community are being studied, and there is a growing interest in the industrial production of biomimetics and combinatorial synthesis of naturally occurring marine bioactive principles and their derivatives. Herein, we present a detailed and most comprehensive account of diverse group of bioactive compounds isolated from marine flora and fauna for biomedical applications in this chapter. Further, we have included a detailed account of the mechanism of actions and scientific rationale of these potential drug candidates.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Blockley A, Elliott D, Roberts A, Sweet M (2017) Symbiotic microbes from marine invertebrates: driving a new era of natural product drug discovery. Diversity 9:49. https://doi.org/10.3390/d9040049
Bonfanti M, La Valle E, Fernandez Sousa Faro JM, Faircloth G, Caretti G, Mantovani R et al (1999) Effect of ecteinascidin-743 on the interaction between DNA binding proteins and DNA. Anticancer Drug Des 14:179ā186
Brƶker LE, Huisman C, Ferreira CG, Rodriguez JA, Kruyt FA, Giaccone G (2002) Late activation of apoptotic pathways plays a negligible role in mediating the cytotoxic effects of discodermolide and epothilone B in non-small cell lung cancer cells. Cancer Res 62:4081ā4088
Chung TW, Choi HJ, Lee JY, Jeong HS, Kim CH, Joo M et al (2013) Marine algal fucoxanthin inhibits the metastatic potential of cancer cells. Biochem Biophys Res Commun 439:580ā585. https://doi.org/10.1016/j.bbrc.2013.09.019
Curiel RE, Garcia CS, Farooq L, Aguero MF, Espinoza-Delgado I (2001) Bryostatin-1 and IL-2 synergize to induce IFN-Ī³ expression in human peripheral blood T cells: implications for cancer immunotherapy. J Immunol 167:4828ā4837. https://doi.org/10.4049/jimmunol.167.9.4828
De Lorenzo MS, Yamaguchi K, Subbaramaiah K, Dannenberg AJ (2003) Bryostatin-1 stimulates the transcription of cyclooxygenase-2: evidence for an activator protein-1-dependent mechanism. Clin Cancer Res 9:5036ā5043
Ermakova S, Sokolova R, Kim SM, Um BH, Isakov V, Zvyagintseva T (2011) Fucoidans from brown seaweeds Sargassum hornery, Eclonia cava, Costaria costata: structural characteristics and anticancer activity. Appl Biochem Biotechnol 164:841ā850. https://doi.org/10.1007/s12010-011-9178-2
Gerard JM, Haden P, Kelly MT, Andersen RJ (1999) Loloatins AāD, cyclic decapeptide antibiotics produced in culture by a tropical marine bacterium. J Nat Prod 62:80ā85. https://doi.org/10.1021/np980219f
Ghosh S, Ahire M, Patil S, Jabgunde A, Bhat Dusane M, Joshi BN et al (2012) Antidiabetic activity of Gnidia glauca and Dioscorea bulbifera: potent amylase and glucosidase inhibitors. Evid Based Complement Alternat Med 2012:929051. https://doi.org/10.1155/2012/929051
Ghosh S, Derle A, Ahire M, More P, Jagtap S, Phadatare SD et al (2013) Phytochemical analysis and free radical scavenging activity of medicinal plants Gnidia glauca and Dioscorea bulbifera. PLoS One 8:e82529. https://doi.org/10.1371/journal.pone.0082529
Ghosh S, More P, Derle A, Patil AB, Markad P, Asok A et al (2014) Diosgenin from Dioscorea bulbifera: novel hit for treatment of type II diabetes mellitus with inhibitory activity against Ī±-amylase and Ī±-glucosidase. PLoS One 9:e106039. https://doi.org/10.1371/journal.pone.0106039
Go H, Hwang HJ, Nam TJ (2010) A glycoprotein from Laminaria japonica induces apoptosis in HT-29 colon cancer cells. Toxicol In Vitro 24:1546ā1553. https://doi.org/10.1016/j.tiv.2010.06.018
Kim D, Lee IS, Jung JH, Yang SI (1999) Psammaplin A, a natural bromotyrosine derivative from a sponge, possesses the antibacterial activity against methicillin-resistant Staphylococcus aureus and the DNA gyrase-inhibitory activity. Arch Pharm Res 22:25ā29. https://doi.org/10.1007/BF02976431
Kim YM, Kim IH, Nam TJ (2012) Induction of apoptosis signaling by glycoprotein of Capsosiphon fulvescens in human gastric cancer (AGS) cells. Nutr Cancer 64:761ā769. https://doi.org/10.1080/01635581.2012.683228
Lee JC, Son YO, Pratheeshkumar P, Shi X (2012) Oxidative stress and metal carcinogenesis. Free Radic Biol Med 53:742ā757. https://doi.org/10.1016/j.freeradbiomed.2012.06.002
Lee JC, Hou MF, Huang HW, Chang FR, Yeh CC, Tang JY et al (2013) Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties. Cancer Cell Int 13:55. https://doi.org/10.1186/1475-2867-13-55
Lin H, Chen C, Li X, Chen BD (2002) Activation of the MEK/MAPK pathway is involved in bryostatin1-induced monocytic differentiation and up-regulation of X-linked inhibitor of apoptosis protein. Exp Cell Res 272:192ā198. https://doi.org/10.1006/excr.2001.5417
Marco E, MartĆn-SantamarĆa S, Cuevas C, Gago F (2004) Structural basis for the binding of didemnins to human elongation factor eEF1A and rationale for the potent antitumor activity of these marine natural products. J Med Chem 47:4439ā4452. https://doi.org/10.1021/jm0306428
Matsunaga S, Okada Y, Fusetani N, van Soest RW (2000) An antimicrobial C (14) acetylenic acid from a marine sponge Oceanapia species. J Nat Prod 63:690ā691. https://doi.org/10.1021/np990577y
Mayer AM, Gustafson KR (2003) Marine pharmacology in 2000: antitumor and cytotoxic compounds. Int J Cancer 105:291ā299. https://doi.org/10.1002/ijc.11080
Mayer AM, Gustafson KR (2004) Marine pharmacology in 2001ā2: antitumour and cytotoxic compounds. Eur J Cancer 40:2676ā2704. https://doi.org/10.1016/j.ejca.2004.09.005
Mayer AM, Gustafson KR (2006) Marine pharmacology in 2003ā2004: anti-tumour and cytotoxic compounds. Eur J Cancer 42:2241ā2270. https://doi.org/10.1016/j.ejca.2006.05.019
Mayer AM, Gustafson KR (2008) Marine pharmacology in 2005ā2006: antitumour and cytotoxic compounds. Eur J Cancer 44:2357ā2387. https://doi.org/10.1016/j.ejca.2008.07.001
Mayer AM, Hamann MT (2002) Marine pharmacology in 1999: compounds with antibacterial, anticoagulant, antifungal, anthelmintic, anti-inflammatory, antiplatelet, antiprotozoal and antiviral activities affecting the cardiovascular, endocrine, immune and nervous systems, and other miscellaneous mechanisms of action. Comp Biochem Physiol C Toxicol Pharmacol 132:315ā339. https://doi.org/10.1016/S1532-0456(02)00094-7
Mayer AM, Hamann MT (2004) Marine pharmacology in 2000: marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antituberculosis, and antiviral activities; affecting the cardiovascular, immune, and nervous systems and other miscellaneous mechanisms of action. Marine Biotechnol (NY) 6(1):37ā52. https://doi.org/10.1007/s10126-003-0007-7
Mayer AM, Hamann MT (2005) Marine pharmacology in 2001ā2002: marine compounds with anthelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems and other miscellaneous mechanisms of action. Comp Biochem Physiol C Toxicol Pharmacol 140:265ā286. https://doi.org/10.1016/j.cca.2005.04.004
Mayer AM, Lehmann VK (2001) Marine pharmacology in 1999: antitumor and cytotoxic compounds. Anticancer Res 21:2489ā2500
Mayer AM, RodrĆguez AD, Berlinck RG, Hamann MT (2007) Marine pharmacology in 2003ā4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action. Comp Biochem Physiol C Toxicol Pharmacol 145(4):553ā581. https://doi.org/10.1016/j.cbpc.2007.01.015
Mayer AM, RodrĆguez A, Taglialatela-Scafati O, Fusetani N (2013) Marine pharmacology in 2009ā2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. Mar Drugs 11(7):2510ā2573. https://doi.org/10.3390/md11072510
Menon K, Alvarez E, Forler P, Phares V, Amsrud T, Shih C et al (2000) Antitumor activity of cryptophycins: effect of infusion time and combination studies. Cancer Chemother Pharmacol 46:142ā149. https://doi.org/10.1007/s002800000135
Mitta G, Hubert F, Noel T, Roch P (1999) Myticin, a novel cysteine-rich antimicrobial peptide isolated from haemocytes and plasma of the mussel Mytilus galloprovincialis. Eur J Biochem 265:71ā78. https://doi.org/10.1046/j.1432-1327.1999.00654.x
Newman DJ, Cragg GM (2014) Marine-sourced anti-cancer and cancer pain control agents in clinical and late preclinical development. Mar Drugs 12:255ā278. https://doi.org/10.3390/md12010255
Panda D, Ananthnarayan V, Larson G, Shih C, Jordan MA, Wilson L (2000) Interaction of the antitumor compound cryptophycin-52 with tubulin. Biochemistry 39:14121ā14127. https://doi.org/10.1021/bi0010827
Shah S, Shah S, Padh H, Kalia K (2015) Genetic alterations of the PIK3CA oncogene in human oral squamous cell carcinoma in an Indian population. Oral Surg Oral Med Oral Pathol Oral Radiol 120:628ā635. https://doi.org/10.1016/j.oooo.2015.08.003
Shah S, Jajal D, Mishra G, Kalia K (2017) Genetic profile of PTEN gene in Indian oral squamous cell carcinoma primary tumors. J Oral Pathol Med 46:106ā111. https://doi.org/10.1111/jop.12468
Shah S, Mishra G, Kalia K (2018) Single nucleotide polymorphism rs 17849071 G/T in the PIK3CA gene is inversely associated with oral cancer. Oral Cancer 2:83ā89. https://doi.org/10.1007/s41548-018-0012-1
Teicher BA, Forler P, Menon K, Phares V, Amsrud T, Shih C (2000) Cryptophycin 52 and cryptophycin 55 in sequential and simultaneous combination treatment regimens in human tumor xenografts. In Vivo 14:471ā480
Vrana JA, Grant S (2001) Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade. Blood 97:2105ā2114. https://doi.org/10.1182/blood.V97.7.2105
Wall NR, Mohammad RM, Al-Katib AM (2001) Mitogen-activated protein kinase is required for bryostatin 1-induced differentiation of the human acute lymphoblastic leukemia cell line Reh. Cell Growth Differ 12:641ā648
Yeh CC, Tseng CN, Yang JI, Huang HW, Fang Y, Tang JY et al (2012) Antiproliferation and induction of apoptosis in Ca9-22 oral cancer cells by ethanolic extract of Gracilaria tenuistipitata. Molecules 17:10916ā10927. https://doi.org/10.3390/molecules170910916
Zewail-Foote M, Hurley LH (1999) Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove. J Medicinal Chem 42:2493ā2497. https://doi.org/10.1021/jm990241l
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
Ā© 2020 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Shah, S., Ghosh, S. (2020). Medicinal Prospects of Marine Flora and Fauna for Drug Discovery. In: Nathani, N.M., Mootapally, C., Gadhvi, I.R., Maitreya, B., Joshi, C.G. (eds) Marine Niche: Applications in Pharmaceutical Sciences . Springer, Singapore. https://doi.org/10.1007/978-981-15-5017-1_18
Download citation
DOI: https://doi.org/10.1007/978-981-15-5017-1_18
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-5016-4
Online ISBN: 978-981-15-5017-1
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)