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Seaweed and Sea Anemones Proteins as a Source of New Pharmaceutical Active Principles

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Marine Niche: Applications in Pharmaceutical Sciences

Abstract

Among marine sources, seaweeds and sea anemones are highly attractive for their diversity and complex composition, the major components being polysaccharides, proteins, pigments, phenolic compounds, vitamins, and minerals. Seaweeds and sea anemones could be a source of different proteins and peptides with unique structures with interesting biological properties, such as antitumoral, antimicrobial, anti-inflammatory, antidiabetic, and antioxidant, among others. This chapter presents an overview of the marine algal and anemone bioactive proteins and peptides, their extraction and the development of novel carrier systems with potential interest for pharmaceutical applications.

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References

  • Admassu H, Gasmalla MAA, Yang R, Zhao W (2018) Bioactive peptides derived from seaweed protein and their health benefits: antihypertensive, antioxidant, and antidiabetic properties. J Food Sci 83:6–16

    Article  CAS  PubMed  Google Scholar 

  • Ahmad TB, Liu L, Kotiw M, Benkendorff K (2018) Review of anti-inflammatory, immune-modulatory and wound healing properties of molluscs. J Ethnopharmacol 210:156–178

    Article  CAS  PubMed  Google Scholar 

  • Alboofetileh M, Rezaei M, Tabarsa M, You S, Mariatti F, Cravotto G (2019) Subcritical water extraction as an efficient technique to isolate biologically-active fucoidans from Nizamuddinia zanardinii. Int J Biol Macromol 128:244–253

    Article  CAS  PubMed  Google Scholar 

  • Alonso JM (2004) Nanomedicines for overcoming biological barriers. Biomed Pharmacother 58:168–172

    Article  CAS  PubMed  Google Scholar 

  • Álvarez C, Mancheño JM, Martínez D, Tejuca M, Pazos F, Lanio ME (2009) Sticholysins, two pore-forming toxins produced by the Caribbean Sea anemone Stichodactyla helianthus: their interaction with membranes. Toxicon 54:1135–1147

    Article  CAS  PubMed  Google Scholar 

  • Antosova Z, Mackova M, Kral V, Macek T (2009) Therapeutic application of peptides and proteins: parenteral forever? Trends Biotechnol 27:628–635

    Article  CAS  PubMed  Google Scholar 

  • Arbeloa EM, Carignan MO, Acuña FH, Churio MS, Carreto JI (2010) Mycosporine-like amino acid content in the sea anemones Aulactinia marplatensis, Oulactis muscosa and Anthothoe chilensis. Comp Biochem Physiol B Biochem Mol Biol 56:216–221

    Article  CAS  Google Scholar 

  • Aryee AN, Agyei D, Akanbi TO (2018) Recovery and utilization of seaweed pigments in food processing. Curr Opin Food Sci 19:113–119

    Article  Google Scholar 

  • Braz L, Grenha A, Ferreira D, Rosa da Costa AM, Gamazo C, Sarmento B (2017) Chitosan/sulfated locust bean gum nanoparticles: in vitro and in vivo evaluation towards an application in oral immunization. Int J Biol Macromol 96:786–797

    Article  CAS  PubMed  Google Scholar 

  • Bulati M, Longo A, Masullo T, Vlah S, Bennici C, Bonura A, Salamone M, Tagliavia M, Nicosia A, Mazzola S, Colombo P, Cuttitta A (2016) Partially purified extracts of sea anemone Anemonia viridis affect the growth and viability of selected tumour cell lines. Biomed Res Int 2016:art no. 3849897

    Article  CAS  Google Scholar 

  • Carmeliet P, Jain RK (2011) Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov 10:417–427

    Article  CAS  PubMed  Google Scholar 

  • Cardoso M, Costa R, Mano J (2016) Marine origin polysaccharides in drug delivery systems. Mar Drugs 14:34

    Article  CAS  PubMed Central  Google Scholar 

  • Casettari L, Illum L (2014) Chitosan in nasal delivery systems for therapeutic drugs. J Control Release 190:189–200

    Article  CAS  PubMed  Google Scholar 

  • Celedón G, González G, Barrientos D, Pino J, Venegas F, Lissi EA, Soto C, Martinez D, Alvarez C, Lanio ME (2008) Stycholysin II, a cytolysin from the sea anemone Stichodactyla helianthus promotes higher hemolysis in aged red blood cells. Toxicon 51:1383–1390

    Article  CAS  PubMed  Google Scholar 

  • Cheow WS, Kiew TY, Hadinoto K (2015) Amorphous nanodrugs prepared by complexation with polysaccharides: carrageenan versus dextran sulfate. Carbohydr Polym 117:549–558

    Article  CAS  PubMed  Google Scholar 

  • Cheung RCF, Ng TB, Wong JH (2015) Marine peptides: bioactivities and applications. Mar Drugs 13(7):4006–4043

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chu TW, Wang ZG, Zhu PF (2007) Regulation of vascular endothelial growth factor on the expression of fracture healing-related factors. Chinese J Traumat - English Ed. 10(6):345–348

    CAS  Google Scholar 

  • Cian RE, Drago SR, De Medina FS, Martínez-Augustin O (2015) Proteins and carbohydrates from red seaweeds: evidence for beneficial effects on gut function and microbiota. Mar Drugs 13:5358–5383

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cleland JL, Daugherty A, Mrsny R (2001) Emerging protein delivery methods. Curr Opin Biotechnol 12(2):212–219

    Article  CAS  PubMed  Google Scholar 

  • Colliec-Jouault S (2015) Chapter 5 – skin tissue engineering using functional marine biomaterials. In: Kim S-K (ed) Functional marine biomaterials. Elsevier Ltd, Amsterdam, pp 69–90

    Chapter  Google Scholar 

  • Csaba N, Garcia-Fuentes M, Alonso MJ (2006) The performance of nanocarriers for transmucosal drug delivery. Expert Opin Drug Deliv 3:463–478

    Article  CAS  PubMed  Google Scholar 

  • Cunha L, Grenha A (2016) Sulfated seaweed polysaccharides as multifunctional materials in drug delivery applications. Mar Drugs 14(3):42

    Article  CAS  PubMed Central  Google Scholar 

  • Davies MS, Jones HD, Hawkins SJ (1990) Seasonal variation in the composition of pedal mucus from Patella vulgata L. J Exp Mar Biol Ecol 144:101–112

    Article  Google Scholar 

  • de Jesus Raposo M, de Morais A, de Morais R (2015) Marine polysaccharides from algae with potential biomedical applications. Mar Drugs 13(5):2967–3028

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Denis C, Le Jeune H, Gaudin P, Fleurence J (2009) An evaluation of methods for quantifying the enzymatic degradation of red seaweed Grateloupia turuturu. J Appl Phycol 21:153–159

    Article  CAS  Google Scholar 

  • Diochot S, Schweitz H, Béress L, Lazdunski M (1998) Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4. J Biol Chem 273(12):6744–6749

    Article  CAS  PubMed  Google Scholar 

  • Diochot S, Loret E, Bruhn T, Beress L, Lazdunski M (2003) APETx1, a new toxin from the sea anemone Anthopleura elegantissima, blocks voltage-gated human ether-a-go-go-related gene potassium channels. Mol Pharmacol 64:59–69

    Article  CAS  PubMed  Google Scholar 

  • Dionísio M, Cordeiro C, Remuñán-López C, Seijo B, Rosa da Costa AM, Grenha A (2013) Pullulan-based nanoparticles as carriers for transmucosal protein delivery. Eur J Pharm Sci 50:102–113

    Article  CAS  PubMed  Google Scholar 

  • Draget KI, Taylor C (2011) Chemical, physical and biological properties of alginates and their biomedical implications. Food Hydrocoll 25:251–256

    Article  CAS  Google Scholar 

  • Driscoll PC, Gronenborn AM, Clore GM (1989) The influence of stereospecific assignments on the determination of three-dimensional structures of proteins by nuclear magnetic resonance spectroscopy. Application to the sea anemone protein BDS-I. FEBS Lett 243(2):223–233

    Article  CAS  PubMed  Google Scholar 

  • Dutertre S, Lewis RJ (2010) Use of venom peptides to probe ion channel structure and function. J Biol Chem 285:13315–13320

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fernández-Díaz C, Coste O, Malta E (2017) Polymer chitosan nanoparticles functionalized with Ulva ohnoi extracts boost in vitro ulvan immunostimulant effect in Solea senegalensis macrophages. Algal Res 26:135–142

    Article  Google Scholar 

  • Fleurence J (1999) Seaweed proteins: biochemical, nutritional aspects and potential uses. Trends Food Sci Technol 10(1):25–28

    Article  CAS  Google Scholar 

  • Fleurence J, Massiani L, Guyader O, Mabeau S (1995) Use of enzymatic cell wall degradation for improvement of protein extraction from Chondrus crispus, Gracilaria verrucosa and Palmaria palmate. J Appl Phycol 7:393–397

    Article  CAS  Google Scholar 

  • Flórez-Fernández N, Casas MP, González-Muñoz MJ, Domínguez H (2017) Combination of water-based extraction technologies. In: Domínguez H, González-Muñoz MJ (eds) Water extraction of bioactive compounds. Elsevier, Oxford

    Google Scholar 

  • Folkman J, Merler E, Abernathy C, Williams G (1971) Isolation of a tumor factor responsible for angiogenesis. J Exp Med 133:275–288

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • GarcÚa-FernÃndez R, Perbandt M, Rehders D, Ziegelmﺲller P, Piganeau N, Hahn U, Betzel C, De Los êngeles ChÃvez M, Redecke L. Three-dimensional structure of a Kunitz-type inhibitor in complex with an elastase-like enzyme. J Bioll Chem. 2015; 290, 22, 14154-14165

    Google Scholar 

  • Gepp MM, Fischer B, Schulz A, Dobringer J, Gentile L, Vásquez JA (2017) Bioactive surfaces from seaweed-derived alginates for the cultivation of human stem cells. J Appl Phycol 29:2451–2461

    Article  CAS  Google Scholar 

  • Gereniu CRN, Saravana PS, Getachew AT, Chun BS (2017) Characteristics of functional materials recovered from Solomon Islands red seaweed (Kappaphycus alvarezii) using pressurized hot water extraction. J Appl Phycol 29:1609–1621

    Article  CAS  Google Scholar 

  • González-López N, Moure A, Domínguez H (2012) Hydrothermal fractionation of Sargassum muticum biomass. J Appl Phycol 24:1569–1578

    Article  CAS  Google Scholar 

  • Grenha A (2012) Chitosan nanoparticles: a survey of preparation methods. J Drug Target 20:291–300

    Article  CAS  PubMed  Google Scholar 

  • Grenha A, Gomes ME, Rodrigues M, Santo VE, Mano JF, Neves NM (2010) Development of new chitosan/carrageenan nanoparticles for drug delivery applications. J Biomed Mater Res Part A 92:1265–1272

    Google Scholar 

  • Hamid N, Ma Q, Boulom S, Liu T, Zheng Z, Balbas J (2015) Chapter 8 – seaweed minor constituents. In: Tiwari BK, Troy DJ (eds) Seaweed sustainability. Academic, San Diego, pp 193–242

    Chapter  Google Scholar 

  • Harnedy PA, O'Keeffe MB, FitzGerald RJ (2017) Fractionation and identification of antioxidant peptides from an enzymatically hydrolysed Palmaria palmata protein isolate. Food Res Int 100:416–422

    Article  CAS  PubMed  Google Scholar 

  • Hayes M, Tiwari BK (2015) Bioactive carbohydrates and peptides in foods: an overview of sources, downstream processing steps and associated bioactivities. Int J Mol Sci 16:22485–22508

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Holdt SL, Kraan S (2011) Bioactive compounds in seaweed: functional food applications and legislation. J Appl Phycol 23:543–597

    Article  CAS  Google Scholar 

  • Huang YC, Lam UI (2011) Chitosan/fucoidan pH sensitive nanoparticles for oral delivery system. J Chin Chem Soc 58:779–785

    Article  CAS  Google Scholar 

  • Huang Y-C, Li R-Y (2014) Preparation and characterization of antioxidant nanoparticles composed of chitosan and fucoidan for antibiotics delivery. Mar Drugs 12:4379–4398

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Huang YC, Li RY, Chen JY, Chen JK (2016) Biphasic release of gentamicin from chitosan/fucoidan nanoparticles for pulmonary delivery. Carbohydr Polym 138:114–122

    Article  CAS  PubMed  Google Scholar 

  • ISO/TS (2015) 80004–1:2015 – nanotechnologies – vocabulary – part 1: core terms. International Standard Organization, Geneva

    Google Scholar 

  • Kadam SU, Tiwari BK, Álvarez C, O'Donnell CP (2015) Ultrasound applications for the extraction, identification and delivery of food proteins and bioactive peptides. Trends Food Sci Technol 46(1):60–67

    Article  CAS  Google Scholar 

  • Kammona O, Kiparissides C (2012) Recent advances in nanocarrier-based mucosal delivery of biomolecules. J Control Release 161:781–794

    Article  CAS  PubMed  Google Scholar 

  • Kong DH, Kim MR, Jang JH, Na HJ, Lee SA (2017) Review of anti-angiogenic targets for monoclonal antibody cancer therapy. Int J Mol Sci 18:art no. E1786

    Article  CAS  Google Scholar 

  • Laurienzo P (2010) Marine polysaccharides in pharmaceutical applications: an overview. Mar Drugs 8:2435–2465

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lauritano C, Ianora A (2016) Marine organisms with anti-diabetes properties. Mar Drugs 14(12):22

    Article  CAS  Google Scholar 

  • Le Guillard C, Dumay J, Donnay-Moreno C, Bruzac S, Ragon JY, Fleurence J, Bergé JP (2015) Ultrasound-assisted extraction of R-phycoerythrin from Grateloupia turuturu with and without enzyme addition. Algal Res 12:522–528

    Article  Google Scholar 

  • Li Y, Wang X, Jiang Y, Wang J, Hwang H, Yang X (2019) Structure characterization of low molecular weight sulfate Ulva polysaccharide and the effect of its derivative on iron deficiency anemia. Int J Biol Macromol 126:747–754

    Article  CAS  PubMed  Google Scholar 

  • Lima AC, Sher P, Mano JF (2012) Production methodologies of polymeric and hydrogel particles for drug delivery applications. Expert Opin Drug Deliv 9:231–248

    Article  CAS  PubMed  Google Scholar 

  • Logashina YA, Mosharova IV, Korolkova YV, Shelukhina IV, Dyachenko IA, Palikov VA, Palikova YA, Murashev AN, Kozlov SA, Stensvåg K, Andreev YA (2017) Peptide from sea anemone Metridium senile affects transient receptor potential Ankyrin-repeat 1 (TRPA1) function and produces analgesic effect. J Biol Chem 292:2992–3004

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lopes M, Abrahim B, Veiga F, Seiça R, Cabral LM, Arnaud P (2017) Preparation methods and applications behind alginate-based particles. Expert Opin Drug Deliv 14(6):769–782

    Article  CAS  PubMed  Google Scholar 

  • Loret E, Menendez R, Mansuelle P, Sampieri F, Rochat H (1994) Positively charged amino acid residues located similarly in sea anemone and scorpion active principles. J Biol Chem 269:16785–16788

    CAS  PubMed  Google Scholar 

  • Macrander J, Daly M (2016) Evolution of the cytolytic pore-forming proteins (actinoporins) in sea anemones active principles. Toxins (Basel) 8:art no. E368

    Article  CAS  Google Scholar 

  • Macrander J, Broe M, Daly M (2016) Tissue-specific venom composition and differential gene expression in sea anemones. Genome Biol Evol 8:2358–2375

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Manivasagan P, Oh J (2016) Marine polysaccharide-based nanomaterials as a novel source of nanobiotechnological applications. Int J Biol Macromol 82:315–327

    Article  CAS  PubMed  Google Scholar 

  • Massironi A, Morelli A, Grassi L, Puppi D, Braccini S, Maisetta G (2019) Ulvan as novel reducing and stabilizing agent from renewable algal biomass: application to green synthesis of silver nanoparticles. Carbohydr Polym 203:310–321

    Article  CAS  PubMed  Google Scholar 

  • Mittal R, Raghavarao KSMS (2018) Extraction of R-Phycoerythrin from marine macro-algae, Gelidium pusillum, employing consortia of enzymes. Algal Res 34:1–11

    Article  Google Scholar 

  • Mittal R, Tavanandi HA, Mantri VA, Raghavarao KSMS (2017) Ultrasound assisted methods for enhanced extraction of phycobiliproteins from marine macro-algae, Gelidium pusillum. Ultrason Sonochem 38:92–103

    Article  CAS  PubMed  Google Scholar 

  • Moran Y, Praher D, Schlesinger A, Ayalon A, Tal Y, Technau U (2013) Analysis of soluble protein contents from the nematocysts of a model sea anemone sheds light on venom evolution. Mar Biotechnol 15:329–339

    Article  CAS  Google Scholar 

  • Mourão CBF, Schwartz EF (2013) Protease inhibitors from marine venomous animals and their counterparts in terrestrial venomous animals. Mar Drugs 11(6):2069–2112

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Oliveira JS, Zaharenko AJ, Ferreira WA Jr, Konno K, Shida CS, Richardson M, Lúcio AD, Beirão PSL, de Freitas JC (2006) BcIV, a new paralyzing peptide obtained from the venom of the sea anemone Bunodosoma caissarum. A comparison with the Na+ channel toxin BcIII. Biochim Biophys Acta, Proteins Proteomics 10:1592–1600

    Article  CAS  Google Scholar 

  • Otero M, Cebrian E, Francour P, Galil B, Savini D (2013) Surveillance des espèces envahissantes marines dans les aires marines protégées (AMP) méditerranéennes: guide pratique et stratégique à l’attention des gestionnaires. Revue de l’UICN

    Google Scholar 

  • Pangestuti R, Kim SK (2011) Biological activities and health benefit effects of natural pigments derived from marine algae. J Funct Foods 3:255–266

    Article  CAS  Google Scholar 

  • Pangestuti R, Getachew AT, Siahaan EA, Chun B-S (2019) Characterization of functional materials derived from tropical red seaweed Hypnea musciformis produced by subcritical water extraction systems. J Appl Phycol. https://doi.org/10.1007/s10811-019-1754-9

  • Pedrera L, Fanani ML, Ros U, Lanio ME, Maggio B, Álvarez C (2014) Sticholysin I-membrane interaction: an interplay between the presence of sphingomyelin and membrane fluidity. Biochim Biophys Acta Biomembr 1838:1752–1759

    Article  CAS  Google Scholar 

  • Peng Y, Hu J, Yang B, Lin XP, Zhou XF, Yang XW (2015) Chapter 5 – chemical composition of seaweeds. In: Tiwari BK, Troy DJ (eds) Seaweed sustainability. Elsevier Inc, Amsterdam, pp 79–124

    Chapter  Google Scholar 

  • Popa EG, Gomes ME, Reis RL (2011) Cell delivery systems using alginate–carrageenan hydrogel beads and fibers for regenerative medicine applications. Biomacromolecules 12:3952–3961

    Article  CAS  PubMed  Google Scholar 

  • Priyan Shanura Fernando I, Kim KN, Kim D, Jeon YJ (2019) Algal polysaccharides: potential bioactive substances for cosmeceutical applications. Crit Rev Biotechnol 39:99–113

    Article  CAS  Google Scholar 

  • Rioux LE, Turgeon S (2015) Chapter 7 – seaweed carbohydrates. In: Tiwari BK, Troy DJ (eds) Seaweed sustainability: food and non-food applications. Elsevier Inc, Amsterdam, pp 141–192

    Chapter  Google Scholar 

  • Rodolfo-Metalpa RI, Richard C, Allemand D, Ferrier-Pagès C (2006) Growth and photosynthesis of two Mediterranean corals, Cladocora caespitosa and Oculina patagonica, under normal and elevated temperatures. J Exp Biol 209:4546–4556

    Article  PubMed  Google Scholar 

  • Rodrigues S, Cordeiro C, Seijo B, Remuñán-López C, Grenha A (2015) Hybrid nanosystems based on natural polymers as protein carriers for respiratory delivery: stability and toxicological evaluation. Carbohydr Polym 123:369–380

    Article  CAS  PubMed  Google Scholar 

  • Rowe RC, Sheskey PJ, Quinn ME (eds) (2009) Handbook of pharmaceutical excipients, 6th edn. Pharmaceutical Press/The American Pharmacists Association, London/Washington, DC

    Google Scholar 

  • Qu W, Ma H, Liu B, He R, Pan Z, Abano EE (2013) Enzymolysis reaction kinetics and thermodynamics of defatted wheat germ protein with ultrasonic pretreatment. Ultrason Sonochem 20(6):1408–1413

    Article  CAS  PubMed  Google Scholar 

  • Qu W, Ma H, Li W, Pan Z, Owusu J, Venkitasamy C (2015) Performance of coupled enzymatic hydrolysis and membrane separation bioreactor for antihypertensive peptides production from Porphyra yezoensis protein. Process Biochem 50(2):245–252

    Article  CAS  Google Scholar 

  • Samarakoon K, Jeon Y-J (2012) Bio-functionalities of proteins derived from marine algae - A review. Food Res Int 48(2):948–960

    Article  CAS  Google Scholar 

  • Singh R, Lillard JW (2009) Nanoparticle-based targeted drug delivery. Exp Mol Pathol 86:215–223

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stabili L, Schirosi R, Parisi MG, Piraino S, Cammarata M (2015) The mucus of Actinia equina (Anthozoa, Cnidaria): an unexplored resource for potential applicative purposes. Mar Drugs 13(8):5276–5296

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stiger-Pouvreau V, Bourgougnon N, Deslandes E (2016) Chapter 8 – carbohydrates from seaweeds. In: Fleurence J, Levine I (eds) Seaweed in health and disease prevention. Elsevier, San Diego, pp 223–274

    Chapter  Google Scholar 

  • Soares, T.S., Oliveira, F., Torquato, R.J.S., Sasaki, S.D., Araujo, M.S., Paschoalin, T., Tanaka, A.S. BmTI-A, a Kunitz type inhibitor from Rhipicephalus microplus able to interfere in vessel formation.Veterinary Parasitol. 2016; 219, 44-52

    Google Scholar 

  • Subramanian B, Sangappellai T, Rajak RC, Diraviam B (2011) Pharmacological and biomedical properties of sea anemones Paracondactylis indicus, Paracondactylis sinensis, Heteractis magnifica and Stichodactyla haddoni from East coast of India. Asian Pac J Trop Med 4:722–726

    Article  PubMed  Google Scholar 

  • Thangaraj S, Bragadeeswaran S (2012) Assessment of biomedical and pharmacological activities of sea anemones Stichodactyla mertensii and Stichodactyla gigantea from Gulf of Mannar Biosphere Reserve, southeast coast of India. J Venomous Anim Toxins Incl Trop Dis 18:53–61

    Article  Google Scholar 

  • Tsai LC, Chen CH, Lin CW, Ho YC, Mi FL (2019) Development of multifunctional nanoparticles self-assembled from trimethyl chitosan and fucoidan for enhanced oral delivery of insulin. Int J Biol Macromol 126:141–150

    Article  CAS  PubMed  Google Scholar 

  • Venkatesan J, Lowe B, Anil S, Manivasagan P, Kheraif AA, Kang KH (2015) Seaweed polysaccharides and their potential biomedical applications. Starch – Stärke 67:381–390

    Article  CAS  Google Scholar 

  • Vo TS, Kim SK (2013) Fucoidans as a natural bioactive ingredient for functional foods. J Funct Foods 5:16–27

    Article  CAS  Google Scholar 

  • Wang T, Jónsdóttir R, Kristinsson HG, Hreggvidsson GO, Jónsson JÓ, Thorkelsson G, Ólafsdóttire G (2010) Enzyme-enhanced extraction of antioxidant ingredients from red algae Palmaria palmata. LWT Food Sci Technol 43:1387–1393

    Article  CAS  Google Scholar 

  • Wijesekara I, Kim SK (2010) Angiotensin-I-converting enzyme (ACE) inhibitors from marine resources: prospects in the pharmaceutical industry. Mar Drugs 8:1080–1093

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wijesekara I, Pangestuti R, Kim S-K (2011) Biological activities and potential health benefits of sulfated polysaccharides derived from marine algae. Carbohydr Polym 84:14–21

    Article  CAS  Google Scholar 

  • Wijesinghe WAJP, Jeon YJ (2012) Biological activities and potential industrial applications of fucose rich sulfated polysaccharides and fucoidans isolated from brown seaweeds: a review. Carbohydr Polym 88:13–20

    Article  CAS  Google Scholar 

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Acknowledgments

The authors wish to express their gratitude to the Ministry of Science, Innovation and Universities of Spain (RTI2018-096376-B-I00) and to the Portuguese Foundation for Science and Technology (UID/Multi/04326/2019). M.D.T. thanks the Spanish Ministry of Science, Innovation and Universities for her postdoctoral grant (IJCI-2016-27535), and N.F.F. thanks Xunta de Galicia for her postdoctoral grant (ED481B 2018/071).

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Flórez-Fernández, N., Torres, M.D., Braz, L., Grenha, A., Loret, E.P., Domínguez, H. (2020). Seaweed and Sea Anemones Proteins as a Source of New Pharmaceutical Active Principles. In: Nathani, N.M., Mootapally, C., Gadhvi, I.R., Maitreya, B., Joshi, C.G. (eds) Marine Niche: Applications in Pharmaceutical Sciences . Springer, Singapore. https://doi.org/10.1007/978-981-15-5017-1_11

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