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Plant Phenolics for Overcoming Multidrug Resistance in Human Fungal Pathogen

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Plant Phenolics in Sustainable Agriculture

Abstract

In spite of significant advances being made in the improvement of antifungal drugs, only limited number of drugs is currently available, and that too are not able to keep pace with the evolution of multidrug resistance (MDR). The urgent need includes the development of alternative drugs that are more efficient and tolerant than those traditionally already in use. Natural plant phenolics are among the most commonly occurring type of secondary metabolite in nature which is constantly being expanded through the discovery of new natural products. Interest in phenolics and the search for new biological activities within members of this class have intensified in recent years, as evidenced by the evaluation of their potential antifungal activities. Among most human pathogenic fungi, Candida albicans is of extreme importance due to their high frequency of colonization and infection in humans. Since nature has plethora of many promising natural compounds which can efficiently be exploited to improve the antifungal therapeutics, the objective of this book chapter is to describe the development of plant phenolics as antifungals for the treatment of Candida species and to note the most promising compounds with their diverse mechanism of actions and their uses in combination with traditional drugs.

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Authors and Affiliations

  1. Amity Institute of Biotechnology, Amity University Haryana, Gurugram, Haryana, India

    Shweta Singh, Zeeshan Fatima & Saif Hameed

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  1. Shweta Singh
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  2. Zeeshan Fatima
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  3. Saif Hameed
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Editors and Affiliations

  1. Department of Botany, Sant Baba Bhag Singh University, Jalandhar, Punjab, India

    Rafiq Lone

  2. Department of Botany, University of Kashmir, Srinagar, Jammu and Kashmir, India

    Razia Shuab

  3. Center of Research for Development, University of Kashmir, Srinagar, Jammu and Kashmir, India

    Azra N. Kamili

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Singh, S., Fatima, Z., Hameed, S. (2020). Plant Phenolics for Overcoming Multidrug Resistance in Human Fungal Pathogen. In: Lone, R., Shuab, R., Kamili, A. (eds) Plant Phenolics in Sustainable Agriculture . Springer, Singapore. https://doi.org/10.1007/978-981-15-4890-1_17

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