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Transcriptional Regulators in Bacillus anthracis: A Potent Biothreat Agent

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Recent Developments in Microbial Technologies

Part of the book series: Environmental and Microbial Biotechnology ((EMB))

Abstract

Transcriptional regulators are highly dynamic modulator proteins that bind to the specific DNA targets. These achieve their regulatory effects via activators or promoters. Consequently, the gene transcription is either upregulated or downregulated. These are known to be an integral component of the cell signaling and signal transduction cascade. CodY is a DNA-binding protein that regulates the transcription of several genes involved in crucial cellular activities. Bacillus anthracis is a potent biowarfare agent. Within the bacterium, the CodY targets include genes involved in metabolism, amino acid biosynthesis and transport, nitrogen assimilation, motility, biofilm formation, sporulation, and virulence. Owing to the vitality of the CodY protein in its anthrax pathogenesis, it becomes pertinent to broaden our horizon on its structural and functional attributes.

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Authors and Affiliations

  1. School of Biotechnology, Jawaharlal Nehru University, New Delhi, India

    Shikha Joon

  2. Computational and Structural Biology Lab, Department of Biological Sciences and Engineering, Netaji Subhas University of Technology, New Delhi, India

    Sonika Bhatnagar

  3. Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Rakesh Bhatnagar

Authors
  1. Shikha Joon
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  2. Sonika Bhatnagar
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  3. Rakesh Bhatnagar
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Corresponding author

Correspondence to Rakesh Bhatnagar .

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Editors and Affiliations

  1. Department of Botany, Mahatma Gandhi Central University, Motihari, Bihar, India

    Ram Prasad

  2. Himalayan School of Biosciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India

    Vivek Kumar

  3. Department of Microbiology, Lovely Professional University, Phagwara, Punjab, India

    Joginder Singh

  4. Department of Biotechnology, Dr Harisingh Gour Central University, Sagar, Madhya Pradesh, India

    Chandrama Prakash Upadhyaya

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Joon, S., Bhatnagar, S., Bhatnagar, R. (2021). Transcriptional Regulators in Bacillus anthracis: A Potent Biothreat Agent. In: Prasad, R., Kumar, V., Singh, J., Upadhyaya, C.P. (eds) Recent Developments in Microbial Technologies. Environmental and Microbial Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-15-4439-2_17

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