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Metabolic Markers for Early Detection of Gastrointestinal Cancers

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Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers

Part of the book series: Diagnostics and Therapeutic Advances in GI Malignancies ((DTAGIM))

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Abstract

Gastrointestinal cancers are a major threat to humans nowadays, due to their high incidence and mortality rates. The early detection of GI cancers was the key to prevention and treatment. Metabolomic profiling and analysis of volatile biomarkers are new and promising screening tools for the diagnosis of several cancers. Metabolites are small molecules produced during cell metabolism that represent the functional status of cell/tissue/malignant phenotype. Studies on biofluid metabolomics (serum, urine, plasma) are emerging fast on detecting new biomarkers for early diagnosis of cancer diseases and grasp a great promise for diagnostic applications. Volatile Organic Compounds (VOCs) signify diverse volatile metabolites which can be able to emit and diagnose in urine, breath, sweat, and feces. Nowadays, there is an increasing interest in the use and evaluation of VOCs with emerging analytical technologies in the diagnosis of GI cancer. With the advent of novel technologies in clinical diagnosis, metabolome analysis is an effective tool for metabolite profiling of biological processes in cells/tissues. This review emphasizes recent advancements in the identification of GI cancer biomarkers, particularly it focuses on metabolic markers and the emerging field of volatile biomarkers.

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Acknowledgments

The authors gratefully acknowledge UGC, Government of India, for financial support to AMVNP in the form of UGC-CSIR-JRF & SRF under the Grant No: F.No. 19-1/2015(SA-1).

Conflict of Interest

We declare we do not have any conflict of interest.

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Author notes

  1. A. M. V. N. Prathyusha, B. Prathap Naidu, and Pallaval Veera Bramhachari equally contributed.

Authors and Affiliations

  1. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    A. M. V. N. Prathyusha, B. Prathap Naidu & Pallaval Veera Bramhachari

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  1. A. M. V. N. Prathyusha
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  2. B. Prathap Naidu
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  3. Pallaval Veera Bramhachari
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Editors and Affiliations

  1. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

  2. Department of Biochemistry and Bioinformatics, GITAM Institute of Science, Gandhi Institute of Technology and Management (GITAM) (Deemed-to-be-University), Visakhapatnam, Andhra Pradesh, India

    Nageswara Rao Reddy Neelapu

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Prathyusha, A.M.V.N., Naidu, B.P., Veera Bramhachari, P. (2020). Metabolic Markers for Early Detection of Gastrointestinal Cancers. In: Veera Bramhachari, P., Neelapu, N. (eds) Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers . Diagnostics and Therapeutic Advances in GI Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-15-4431-6_5

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