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Future Challenges and Perspectives for Stem Cell Therapy of Neurodegenerative Diseases

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Stem Cell-based Therapy for Neurodegenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1266))

Abstract

Stem cell-based therapy has shown exciting efficacy in pre-clinical studies on different neurodegenerative diseases (NDs). However, no clinically applicable stem-cell-derived neurons are available to the patients with NDs. There exist some obstacles associated with stem cell therapy, which need to be overcome in future clinical studies. In this chapter, more challenges and new strategies will be explored to accelerate the clinical translation of a human embryonic stem cell (hESC)/induced pluripotent stem cell (iPSC)-derived neural cell product to patients with NDs.

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Acknowledgement

This work was supported by National Natural Science Foundation of China (NSFC 81571241), Department of Science and Technology of Shandong Province, China (2017GSF18104), and Basic Research Fund from Natural Science Foundation of Shandong Province, China (ZR2019ZD39), Merit Review Award Number I01 RX002264-01A2 from the United States (U.S.), and Department of Veterans Affairs Rehabilitation Research and Development (RR&D) Service and NIH (R21 NS103074-01).

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Authors and Affiliations

  1. The Institute for Translational Medicine, Affiliated Second Hospital, Shandong University, Jinan, Shandong, China

    Fabin Han

  2. The Institute for Tissue Engineering and Regenerative Medicine, Liaocheng University/Liaocheng People’s Hospital, Liaocheng, Shandong, China

    Fabin Han

  3. Veterans Administration San Diego Healthcare System, San Diego, CA, USA

    Paul Lu

  4. Department of Neurosciences, University of California - San Diego, La Jolla, CA, USA

    Paul Lu

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  1. Fabin Han
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  2. Paul Lu
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Correspondence to Fabin Han .

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Editors and Affiliations

  1. The Second Affiliated Hospital, Shandong University, Jinan, Shandong, China

    Fabin Han

  2. School of Medicine, University of California at San Diego, La Jolla, CA, USA

    Pengzhe (Paul) Lu

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Han, F., Lu, P. (2020). Future Challenges and Perspectives for Stem Cell Therapy of Neurodegenerative Diseases. In: Han, F., Lu, P.(. (eds) Stem Cell-based Therapy for Neurodegenerative Diseases. Advances in Experimental Medicine and Biology, vol 1266. Springer, Singapore. https://doi.org/10.1007/978-981-15-4370-8_10

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