Abstract
Normal gastrointestinal physiology is fundamental for all the living beings. Gastrointestinal diseases mainly include gastrointestinal motility disorders, infectious inflammation (such as Helicobacter pylori infection, cholera, and intestinal parasites), non-infectious inflammation (such as chronic gastritis and Crohn’s disease), and gastrointestinal cancers. In addition, intestinal microbial disorder is also an important cause of intestinal diseases, so intestinal microecological treatment (fecal microbiota transplantation) is an important mean of treating gastrointestinal diseases. In recent years, the role of autophagy in gastrointestinal diseases has been studied extensively. Autophagy is observed under various pathological processes of the gastrointestinal tract. For example, it has been demonstrated that autophagy plays an important role in maintaining the homeostasis and integrity of intestinal epithelium. Additionally, autophagy regulates host response to H. pylori infection and development of gastrointestinal cancers. Therefore, we will discuss pivotal roles of autophagy in various gastrointestinal diseases and analyze the underlying molecular mechanisms, which may provide new therapeutic targets applicable for the treatment of gastrointestinal diseases.
Tao Wang, Kewei Liu, Liangzhi Wen, Yang Yang, Xinru Yin, Kaijun Liu, Yuqin Chen, Yuqin He—These authors contributed equally.
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References
Baumgart DC, Sandborn WJ (2012) Crohn’s disease. Lancet 380:1590–1605
Cai T, Zhang C, Zhao Z et al (2018) The gastric mucosal protective effects of astragaloside IV in mnng-induced GPL rats. Biomed Pharmacother 104:291–299
Girardin SE, Travassos LH, Herve M et al (2003) Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem 278:41702–41708
Halder P, Datta C, Kumar R et al (2015) The secreted antigen, HP0175, of Helicobacter pylori links the unfolded protein response (UPR) to autophagy in gastric epithelial cells. Cell Microbiol 17:714–729
Harada S, Nakagawa T, Yokoe S et al (2015) Autophagy deficiency diminishes indomethacin-induced intestinal epithelial cell damage through activation of the ERK/Nrf2/HO-1 pathway. J Pharmacol Exp Ther 355:353–361
Kaser A, Blumberg RS (2014) Cell biology: stressful genetics in Crohn’s disease. Nature 506:441–442
Klein S, Seidler B, Kettenberger A et al (2013) Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity. Nat Commun 4:1630
Li Y, Xia R, Zhang B et al (2018) Chronic atrophic gastritis: a review. J Environ Pathol Toxicol Oncol 37:241–259
Mizushima N, Yoshimori T, Levine B (2010) Methods in mammalian autophagy research. Cell 140:313–326
New J, Thomas SM (2019) Autophagy-dependent secretion: mechanism, factors secreted, and disease implications. Autophagy 1–12
Oh JE, Lee HK (2014) Pattern recognition receptors and autophagy. Front Immunol 5:300
Shaw MH, Kamada N, Warner N et al (2011) The ever-expanding function of NOD2: autophagy, viral recognition, and T cell activation. Trends Immunol 32:73–79
Song J, Hu Y, Li J et al (2018) Suppression of the toll-like receptor 7-dependent type I interferon production pathway by autophagy resulting from enterovirus 71 and coxsackievirus A16 infections facilitates their replication. Arch Virol 163:135–144
Tanaka S, Nagashima H, Uotani T et al (2017) Autophagy-related genes in Helicobacter pylori infection. Helicobacter 22
Tu SP, Quante M, Bhagat G et al (2011) IFN-gamma inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis. Cancer Res 71:4247–4259
Whelan KA, Merves JF, Giroux V et al (2017) Autophagy mediates epithelial cytoprotection in eosinophilic oesophagitis. Gut 66:1197–1207
Xu Y, Jagannath C, Liu XD et al (2007) Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 27:135–144
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Wang, T. et al. (2020). Autophagy and Gastrointestinal Diseases. In: Le, W. (eds) Autophagy: Biology and Diseases. Advances in Experimental Medicine and Biology, vol 1207. Springer, Singapore. https://doi.org/10.1007/978-981-15-4272-5_38
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DOI: https://doi.org/10.1007/978-981-15-4272-5_38
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