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Autophagy: Biology and Diseases pp 445–461Cite as

Autophagy and Obesity and Diabetes

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 1207)

Abstract

The prevalence of obesity is increasing rapidly and is closely associated with a variety of metabolic diseases. Recent studies have suggested that autophagy is likely to play an important role in the development of obesity and may be related to insulin sensitivity. Autophagy may be involved in the browning of white adipose tissue and may also affect the metabolic balance of lipids. Autophagy can degrade cytoplasmic lipids by lipophagy in hepatocytes. Furthermore, Autophagy in hepatocytes helps prevent NAFLD. The study of autophagy in glucose metabolism is still in a very preliminary stage. Changes in autophagy activity play an important role in the development of insulin resistance in diabetes and many metabolic diseases. Therefore, it is still worth further exploration on the deeper mechanism of oxidative stress induction of insulin resistance to autophagy and whether there will be corresponding complications to the body.

Keywords

  • Autophagy
  • Obesity
  • Diabetes
  • Lipophagy
  • Glucose metabolism

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Fig. 32.1
Fig. 32.2

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road, Shanghai, 200127, China

    Tao Tao

  2. Department of Endocrinology and Metabolism, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, China

    Huanbai Xu

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  1. Tao Tao
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  2. Huanbai Xu
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Correspondence to Tao Tao .

Editor information

Editors and Affiliations

  1. Liaoning Provincial Center for Clinical Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, China

    Prof. Weidong Le

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Tao, T., Xu, H. (2020). Autophagy and Obesity and Diabetes. In: Le, W. (eds) Autophagy: Biology and Diseases. Advances in Experimental Medicine and Biology, vol 1207. Springer, Singapore. https://doi.org/10.1007/978-981-15-4272-5_32

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