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Autophagy and Tumour Radiotherapy

Chapter
First Online:
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1207)

Abstract

Radiotherapy is an important component of cancer treatment modalities. With the rapid development of three-dimensional conformal, intensity-modulated, image-guided radiotherapy and the efficacy of radiotherapy continues to improve. Autophagy, as a catabolic process, is characterized by the formation of a double-membrane vesicle. Radiotherapy is known to induce autophagy in both cancer and normal cells. Here, we reviewed the interaction of radiotherapy and autophagy in the process of cancer treatment. The potential role of autophagy modification in enhancing radiotherapy treatment will also be reviewed.

Keywords

Radiotherapy Autophagy Radiotherapy efficacy Cancer treatment 
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Copyright information

© Science Press and Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  1. 1.Tumor Immunology and Gene Therapy CenterEastern Hepatobiliary Surgery Hospital, The Second Military Medical UniversityShanghaiChina
  2. 2.Department of RadiologyEastern Hepatobiliary Surgery Hospital, The Second Military Medical UniversityShanghaiChina

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