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Autophagy and Alzheimer’s Disease

Chapter
First Online:
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1207)

Abstract

Alzheimer’s disease (AD) is the most common type of dementia and is characterized by progressive cognitive decline. Increasing evidence has demonstrated that the autophagic process plays an important role in AD. In this chapter, we will discuss the role of autophagy in the pathogenesis of AD and other types of dementia, including dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), vascular dementia (VD) and prion diseases. In addition, we will discuss autophagy-targeted therapies as future treatments for AD.

Keywords

Alzheimer’s disease Dementia Autophagy 
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Copyright information

© Science Press and Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  1. 1.Department of Neurology, Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina
  2. 2.Liaoning Provincial Center for Clinical Research on Neurological Diseases, The First Affiliated HospitalDalian Medical UniversityDalianChina

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