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Asthma: Pathophysiology, Current Status, and Therapeutics

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Chronic Lung Diseases

Abstract

Asthma is a chronic disorder of the airways characterized by variable and recurring airway inflammation, bronchial hyperresponsiveness, bronchoconstriction, vasodilatation, airway edema, and activation of sensory nerve endings. It is a serious health problem globally affecting 334 million people across all the age groups imposing a substantial burden on patient’s quality of life, family, and community. Patients with asthma are often at the risk of acute exacerbations, if the symptoms are not managed properly, and it needs to be customized based on the level of symptom control, phenotypic characteristics, effectiveness of available medications, safety, cost-effectiveness, etc. Since the underlying pathophysiological mechanisms and symptoms of the disease are complicated, there is a dire need to understand the pathology of the disease for better management of symptoms and development of novel therapeutic approaches. Here, we have presented a comprehensive review of the disease, its causes, epidemiology, pathophysiology, current drug treatments, and latest recommendations from Global Initiative for Asthma for the management of asthma.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA

    Javeed Ahmad Bhat

  2. Department of Cell Systems and Anatomy, School of Medicine, UT Health, San Antonio, TX, USA

    Nawab John Dar

  3. Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA

    Wajid Waheed Bhat

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  1. Javeed Ahmad Bhat
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Correspondence to Nawab John Dar .

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  1. Department of Pharmacology, University of Illinois at Chicago, Illinois, IL, USA

    Sheikh Rayees

  2. Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, India

    Inshah Din

  3. Toxicology, CSIR-IIM, Jammu, Jammu and Kashmir, India

    Gurdarshan Singh

  4. Cancer Pharmacology, CSIR-IIM, Jammu, Jammu and Kashmir, India

    Fayaz A Malik

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Bhat, J.A., Dar, N.J., Bhat, W.W. (2020). Asthma: Pathophysiology, Current Status, and Therapeutics. In: Rayees, S., Din, I., Singh, G., Malik, F. (eds) Chronic Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-15-3734-9_2

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