Skip to main content
SpringerLink
Log in

Anticholinergics

  • Chapter
  • First Online:
Pharmacology in Clinical Neurosciences

Abstract

Name: Glycopyrrolate

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 279.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Agency UEP (2018) Glycopyrrolate: United States Environmental Protection Agency. Available from: https://comptox.epa.gov/dashboard/DTXSID2048165

  • Alsop S, Moore J, Rollins D, Tolman K (1984) The effects of five potassium chloride preparations on the upper gastrointestinal mucosa in health subjects receiving glycopyrrolate. J Clin Pharmacol 24:235–239

    Article  CAS  PubMed  Google Scholar 

  • Anderson CS, Arima H, Lavados P, Billot L, Hackett ML, Olavarria VV et al (2017) Cluster-randomized, crossover trial of head positioning in acute stroke. N Engl J Med 376(25):2437–2447

    Article  PubMed  Google Scholar 

  • Barrington KJ (2011) The myth of a minimum dose for atropine. Pediatrics 127(4):783–784

    Article  PubMed  Google Scholar 

  • Bernheim A, Fatio R, Kiowski W, Weilenmann D, Rickli H, Brunner-La RH (2004) Atropine often results in complete atrioventricular block or sinus arrest after cardiac transplantation: an unpredictable and dose-independent phenomenon. Transplantation 77(8):1181–1185

    Article  CAS  PubMed  Google Scholar 

  • Chamberlain DA, Turner P, Sneddon JM (1967) Effects of atropine on heart-rate in healthy man. Lancet 2(7505):12–15

    Article  CAS  PubMed  Google Scholar 

  • Clark R, Brown M, Lattin D (1996) Neostigmine, atropine, and glycopyrrolate: does neostigmine cross the placenta? Anesthesiology 84:450–452

    Article  CAS  PubMed  Google Scholar 

  • Cook B, Spence AA (1997) Post-operative central anticholinergic syndrome. Eur J Anaesthesiol 14(1):1–2

    Article  CAS  PubMed  Google Scholar 

  • Cronnelly R, Morris RB, Miller RD (1982) Edrophonium: duration of action and atropine requirement in humans during halothane anesthesia. Anesthesiology 57(4):261–266

    Article  CAS  PubMed  Google Scholar 

  • Dampney RAL, Coleman MJ, Fontes MAP, Hirooka Y, Horiuchi J, Li YW et al (2002) Central mechanisms underlying short- and long-term regulation of the cardiovascular system. Clin Exp Pharmacol Physiol 29(4):261–268

    Article  CAS  PubMed  Google Scholar 

  • Dauchot P, Gravenstein JS (1971) Effects of atropine on the electrocardiogram in different age groups. Clin Pharmacol Ther 12(2):274–280

    Article  CAS  PubMed  Google Scholar 

  • Ducharme N, Fubini S (1983) Gastrointestinal complications associated with the use of atropine in horses. J Am Vet Med Assoc 182(3):229–231

    CAS  PubMed  Google Scholar 

  • Gallanosa A, Bhimji S (2018) Glycopyrrolate. StatPearls, Treasure Island, FL. [updated 9/12/18]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526035/

  • Glaser SRMA, Sclar DM, Sala NA, Vroman CM, Tanner CE et al (2002) A randomized trial of atropine vs. patching for treatment of moderate amblyopia in children. Arch Ophthalmol 120(3):268–278

    Article  Google Scholar 

  • Howard J, Wigley J, Rosen G, D’Mello J (2017) Glycopyrrolate: it’s time to review. J Clin Anesth 36:51–53

    Article  CAS  PubMed  Google Scholar 

  • Information (n.d.). NCfB. PubChem compound database; CID=5927. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/5927

  • Kanto J, Virtanen R, Iisalo E, Maenpaa K, Liukko P (1981) Placental transfer and pharmacokinetics of atropine after a single maternal intravenous and intramuscular administration. Acta Anaesthesiol Scand 25(2):85–88

    Article  CAS  PubMed  Google Scholar 

  • Kim WO, Kil HK, Yoon KB, Yoon DM (2008) Topical glycopyrrolate for patients with facial hyperhidrosis. Br J Dermatol 158(5):1094–1097

    Article  CAS  PubMed  Google Scholar 

  • Kim JM, Park KH, Han SY, Kim KS, Kim DM, Kim TW et al (2012) Changes in intraocular pressure after pharmacologic pupil dilation. BMC Ophthalmol 12:53

    Article  PubMed  PubMed Central  Google Scholar 

  • Li T, Shotton K (2009) Conventional occlusion versus pharmacologic penalization for amblyopia. Cochrane Database Syst Rev 4:CD006460

    Google Scholar 

  • Maria SA, Claudia C, Pamela G, Andrea C, Roberto A (2012) Medical therapy in Ménière’s disease. Audiological Med 10(4):171–177

    Article  Google Scholar 

  • Massumi RA, Mason DT, Amsterdam EA, DeMaria A, Miller RR, Scheinman MM et al (1972) Ventricular fibrillation and tachycardia after intravenous atropine for treatment of bradycardias. N Engl J Med 287(7):336–338

    Article  CAS  PubMed  Google Scholar 

  • McPherson C (2018) Premedication for endotracheal intubation in the neonate. Neonatal Netw 37(4):238–247

    Article  PubMed  Google Scholar 

  • Mier RJ, Bachrach SJ, Lakin RC, Barker T, Childs J, Moran M (2000) Treatment of sialorrhea with glycopyrrolate. Arch Pediatr Adolesc Med 154(12):1214

    Article  CAS  PubMed  Google Scholar 

  • Mirakhur R, Dundee J (1980) Comparison of the effects of atropine and glycopyrrolate on various end-organs. J R Soc Med 73(10):727–730

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Naguib M, Gomaa M (1989) Atropine-neostigmine mixture: a dose-response study. Can J Anaesth 36(4):412–417

    Article  CAS  PubMed  Google Scholar 

  • Nishtala PS, Salahudeen MS, Hilmer SN (2016) Anticholinergics: theoretical and clinical overview. Expert Opin Drug Saf 15(6):753–768

    Article  CAS  PubMed  Google Scholar 

  • Nolan JP, Hazinski MF, Aickin R, Bhanji F, Billi JE, Callaway CW et al (2015) Part 1: executive summary: 2015 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation 95:e1–e31

    Article  PubMed  Google Scholar 

  • Pharma A (2016) Atropine Sulphate Injection BP 600 micrograms/1mL. London, UK. Available from: https://www.medicines.org.uk/emc/product/5675/smpc

  • Proakis AG, Harris GB (1978) Comparative penetration of glycopyrrolate and atropine across the blood–brain and placental barriers in anesthetized dogs. Anesthesiology 48(5):339–344

    Article  CAS  PubMed  Google Scholar 

  • Rautakorpi P, Manner T, Ali-Melkkilä T, Kaila T, Olkkola K, Kanto J (1998) Pharmacokinetics and oral bioavailability of glycopyrrolate in children. Pharmacol Toxicol 83(3):132–134

    Article  CAS  PubMed  Google Scholar 

  • Rumpler MJ, Colahan P, Sams RA (2014) The pharmacokinetics of glycopyrrolate in Standardbred horses. J Vet Pharmacol Ther 37(3):260–268

    Article  CAS  PubMed  Google Scholar 

  • Volz-Zang C, Waldhauser T, Schulte B, Palm D (1995) Comparison of the effects of atropine in vivo and ex vivo (radioreceptor assay) after oral and intramuscular administration to man. Eur J Clin Pharmacol 49(1–2):45–49

    CAS  PubMed  Google Scholar 

  • Waltham MA (2018, 2018) UpToDate. Atropine (systemic): drug information. UpToDate. Accessed on December 11

    Google Scholar 

  • Yu DY, Galant SP, Gold WM (1972) Inhibition of antigen-induced bronchoconstriction by atropine in asthmatic patients. J Appl Physiol 32(6):823–828

    Article  CAS  PubMed  Google Scholar 

  • Zhou M, Mi J, Yujie L, Zhang H, Fang Y (2011) Determination of atropine sulfate in human urines by capillary electrophoresis using chemical modified electrode as electrochemiluminescence sensor. Int J Electrochem 2011:403691

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Anesthesiology, Maimonides Medical Center, Brooklyn, NY, USA

    Ravi K. Grandhi

  2. Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

    Alaa AbdElsayed

Authors
  1. Ravi K. Grandhi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alaa AbdElsayed
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Neuroanesthesiology & Critical Care, All India Institute of Medical Sciences, New Delhi, Delhi, India

    Hemanshu Prabhakar

  2. Department of Neuroanaesthesiology & Critical Care, All India Institute of Medical Sciences, New Delhi, Delhi, India

    Charu Mahajan

  3. Department of Neuroanaesthesiology & Critical Care, All India Institute of Medical Sciences, New Delhi, Delhi, India

    Indu Kapoor

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Grandhi, R.K., AbdElsayed, A. (2020). Anticholinergics. In: Prabhakar, H., Mahajan, C., Kapoor, I. (eds) Pharmacology in Clinical Neurosciences. Springer, Singapore. https://doi.org/10.1007/978-981-15-3591-8_7

Download citation

Publish with us

Policies and ethics

Search

Navigation