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B Cell Development and Maturation

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 1254)

Abstract

Since the identification of B cells in 1965 (Cooper  et al. 1965), three has been tremendous progress in our understanding of B cell development, maturation and function. A number of B cell subpopulations, including B-1, B-2 and regulatory B cells, have been identified. B-1 cells mainly originate from the fetal liver and contain B-1a and B-1b subsets. B-2 cells are derived from the bone marrow (BM) and can be further classified into follicular B (FOB) and marginal zone B (MZB) cells. Regulatory B cells (Bregs) function to suppress immune responses, primarily by production of the anti-inflammatory cytokine IL-10. B cell tolerance is established at several checkpoints, during B cell development in the BM (central tolerance) as well as during B cell maturation and activation in the periphery (peripheral tolerance). This chapter will focus on the regulation of important processes during the development and maturation of B-1 and B-2 cells.

Keywords

  • Ig gene
  • V(D)J recombination
  • Follicular B
  • Marginal zone B
  • B-1

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Fig. 1.1

(Notes The organization of mouse Igh locus, Igκ locus and Igλ locus. Ψ, pseudogene. Not all gene segments and pseudogenes are shown)

Fig. 1.2
Fig. 1.3
Fig. 1.4
Fig. 1.5

The graph is based on a previously suggested model for B-1a/B-1b development (Hardy 2006), along with the results of mice deficient for or overexpressing CD19 (Haas et al. 2005), mice deficient for BLNK (Pappu et al. 1999) or NCK (Castello et al. 2013), mice heterozygous for CMTM7 (Zhang et al. 2014) and KLHL14−/− mice (Li et al. 2018). Source Adapted from Li et al. (2018)

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Acknowledgements

We thank Luming Zhang for secretarial assistance, Fudan University Animal Facility for maintaining the mice and the members in Wang Laboratory for helpful suggestions. This work was supported by the Major Research Plan of the National Natural Science Foundation of China (91942302 to J.Y.W.), the National Key R & D Plan of the Ministry of Science and Technology (SQ2019YFE0100600 to J.Y.W.), the National Natural Science Foundation of China (81571529 and 31870898 to J.Y.W), Projects of International Cooperation and Exchanges NSFC (81811540035 to J.Y.W.), a grant-in-aid for scientific research (C) from Japan Society for the Promotion of Science (17K08878 to J.Y.W), China Postdoctoral Science Foundation Grant (2018M641929 to J.L.) and National Natural Science Foundation for Young Scholar (81901594 to J.L.).

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Correspondence to Ji-Yang Wang .

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Wang, Y., Liu, J., Burrows, P.D., Wang, JY. (2020). B Cell Development and Maturation. In: Wang, JY. (eds) B Cells in Immunity and Tolerance. Advances in Experimental Medicine and Biology, vol 1254. Springer, Singapore. https://doi.org/10.1007/978-981-15-3532-1_1

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