Skip to main content
SpringerLink
Log in

Systems Immunology Approach in Understanding the Association of Allergy and Cancer

  • Chapter
  • First Online:
Systems and Synthetic Immunology

  • 915 Accesses

Abstract

Epidemiological studies on allergy/asthma and cancer suggest that there exists association between these two types of immunological diseases. Atopic allergy can promote protection from certain types of cancer such as colorectal and esophageal cancers, whereas it may also serve as a risk factor for cancers like lung cancer. There are key immune cells like Tregs and macrophages that play a crucial role in immunoregulation of both the diseases. Besides, PD-1, PD-L1/L2, CTLA4, IgE, Type 2 cytokines regulate allergic manifestations and malignant conditions in the human system. In this chapter, the association of atopic allergy with different types of cancer, and the key immune cells and important molecules associated with both the diseases have been highlighted. In the end, the future perspectives of the field of allergo-oncology and possible therapeutic approaches to modulate the immune systems have been described.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Han H, Roan F, Ziegler SF (2017) The atopic march: current insights into skin barrier dysfunction and epithelial cell-derived cytokines. Immunol Rev 278(1):116–130

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Gonzalez H, Hagerling C, Werb Z (2018) Roles of the immune system in cancer: from tumor initiation to metastatic progression. Genes Dev 32(19–20):1267–1284

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Najafi M, Farhood B, Mortezaee K (2019) Contribution of regulatory T cells to cancer: a review. J Cell Physiol 234(6):7983–7993

    Article  CAS  PubMed  Google Scholar 

  4. Codony-Servat J, Rosell R (2015) Cancer stem cells and immunoresistance: clinical implications and solutions. Transl Lung Cancer Res 4(6):689–703

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Jensen-Jarolim E, Bax HJ, Bianchini R, Crescioli S, Daniels-Wells TR, Dombrowicz D et al (2018) AllergoOncology: opposite outcomes of immune tolerance in allergy and Cancer. Allergy 73(2):328–340

    Article  CAS  PubMed  Google Scholar 

  6. Wang H, Diepgen TL (2005) Is atopy a protective or a risk factor for cancer? A review of epidemiological studies. Allergy 60(9):1098–1111

    Article  CAS  PubMed  Google Scholar 

  7. Vena JE, Bona JR, Byers TE, Middleton E Jr, Swanson MK, Graham S (1985) Allergy-related diseases and cancer: an inverse association. Am J Epidemiol 122(1):66–74

    Article  CAS  PubMed  Google Scholar 

  8. Josephs DH, Spicer JF, Corrigan CJ, Gould HJ, Karagiannis SN (2013) Epidemiological associations of allergy. IgE Cancer Clin Exp Allergy 43(10):1110–1123

    CAS  PubMed  Google Scholar 

  9. Nauta AJ, Engels F, Knippels LM, Garssen J, Nijkamp FP, Redegeld FA (2008) Mechanisms of allergy and asthma. Eur J Pharmacol 585(2–3):354–360

    Article  CAS  PubMed  Google Scholar 

  10. Verhoeckx KCM, Vissers YM, Baumert JL, Faludi R, Feys M, Flanagan S et al (2015) Food processing and allergenicity. Food Chem Toxicol 80:223–240

    Article  CAS  PubMed  Google Scholar 

  11. D’Arcy M, Rivera DR, Grothen A, Engels EA (2019) Allergies and the subsequent risk of cancer among elderly adults in the United States. Cancer Epidemiol Biomark Prev 28(4):741–750

    Article  Google Scholar 

  12. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M et al (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136(5):E359–E386

    Article  CAS  PubMed  Google Scholar 

  13. Pandya PH, Murray ME, Pollok KE, Renbarger JL (2016) The immune system in cancer pathogenesis: potential therapeutic approaches. J Immunol Res 2016:4273943

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  14. Kato T, Noma K, Ohara T, Kashima H, Katsura Y, Sato H et al (2018) Cancer-associated fibroblasts affect Intratumoral CD8(+) and FoxP3(+) T cells via IL6 in the tumor microenvironment. Clin Cancer Res 24(19):4820–4833

    Article  CAS  PubMed  Google Scholar 

  15. Toledo-Guzman ME, Bigoni-Ordonez GD, Ibanez Hernandez M, Ortiz-Sanchez E (2018) Cancer stem cell impact on clinical oncology. World J Stem Cells 10(12):183–195

    Article  PubMed  PubMed Central  Google Scholar 

  16. Kim J, Bae JS (2016) Tumor-associated macrophages and neutrophils in tumor microenvironment. Mediat Inflamm 2016:6058147

    Google Scholar 

  17. Ciszewski WM, Sobierajska K, Wawro ME, Klopocka W, Chefczynska N, Muzyczuk A et al (2017) The ILK-MMP9-MRTF axis is crucial for EndMT differentiation of endothelial cells in a tumor microenvironment. Biochim Biophys Acta, Mol Cell Res 1864(12):2283–2296

    Article  CAS  Google Scholar 

  18. Prasetyanti PR, Medema JP (2017) Intra-tumor heterogeneity from a Cancer stem cell perspective. Mol Cancer 16(1):41

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. Wu T, Dai Y (2017) Tumor microenvironment and therapeutic response. Cancer Lett 387:61–68

    Article  CAS  PubMed  Google Scholar 

  20. Ostrand-Rosenberg S (2016) Tolerance and immune suppression in the tumor microenvironment. Cell Immunol 299:23–29

    Article  CAS  PubMed  Google Scholar 

  21. Selvarajoo K (2014) Advances in systems immunology and Cancer. Front Physiol 5:249

    Article  PubMed  PubMed Central  Google Scholar 

  22. Vesely MD, Kershaw MH, Schreiber RD, Smyth MJ (2011) Natural innate and adaptive immunity to cancer. Annu Rev Immunol 29:235–271

    Article  CAS  PubMed  Google Scholar 

  23. Schreiber RD, Old LJ, Smyth MJ (2011) Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science 331(6024):1565–1570

    Article  CAS  PubMed  Google Scholar 

  24. Mittal D, Gubin MM, Schreiber RD, Smyth MJ (2014) New insights into cancer immunoediting and its three component phases – elimination, equilibrium and escape. Curr Opin Immunol 27:16–25

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Tsuyada A, Chow A, Wu J, Somlo G, Chu P, Loera S et al (2012) CCL2 mediates cross-talk between Cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res 72(11):2768–2779

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Ward-Hartstonge KA, Kemp RA (2017) Regulatory T-cell heterogeneity and the cancer immune response. Clin Transl Immunol 6(9):e154

    Article  CAS  Google Scholar 

  27. Spranger S, Bao R, Gajewski TF (2015) Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity. Nature 523(7559):231–235

    Article  CAS  PubMed  Google Scholar 

  28. Albini A, Bruno A, Noonan DM, Mortara L (2018) Contribution to tumor angiogenesis from innate immune cells within the tumor microenvironment: implications for immunotherapy. Front Immunol 9:527

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  29. Zhao P, Wang Y, Kang X, Wu A, Yin W, Tang Y et al (2018) Dual-targeting biomimetic delivery for anti-glioma activity via remodeling the tumor microenvironment and directing macrophage-mediated immunotherapy. Chem Sci 9(10):2674–2689

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Spranger S, Gajewski TF (2016) Tumor-intrinsic oncogene pathways mediating immune avoidance. Oncoimmunology 5(3):e1086862

    Article  PubMed  CAS  Google Scholar 

  31. Cui Y, Hill AW (2016) Atopy and specific Cancer sites: a review of epidemiological studies. Clin Rev Allergy Immunol 51(3):338–352

    Article  PubMed  Google Scholar 

  32. Olson SH, Hsu M, Satagopan JM, Maisonneuve P, Silverman DT, Lucenteforte E et al (2013) Allergies and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer case-control consortium. Am J Epidemiol 178(5):691–700

    Article  PubMed  PubMed Central  Google Scholar 

  33. Hemminki K, Forsti A, Fallah M, Sundquist J, Sundquist K, Ji J (2014) Risk of cancer in patients with medically diagnosed hay fever or allergic rhinitis. Int J Cancer 135(10):2397–2403

    Article  CAS  PubMed  Google Scholar 

  34. Merrill RM, Isakson RT, Beck RE (2007) The association between allergies and cancer: what is currently known? Ann Allergy Asthma Immunol 99(2):102–116; quiz 17–9, 50

    Article  PubMed  Google Scholar 

  35. McWhorter WP (1988) Allergy and risk of cancer. A prospective study using NHANESI followup data. Cancer 62(2):451–455

    Article  CAS  PubMed  Google Scholar 

  36. Kelly FJ (1999) Gluthathione: in defence of the lung. Food Chem Toxicol 37(9–10):963–966

    Article  CAS  PubMed  Google Scholar 

  37. Boffetta P, Ye W, Boman G, Nyren (2002) Lung cancer risk in a population-based cohort of patients hospitalized for asthma in Sweden. Eur Respir J 19(1):127–133

    Article  CAS  PubMed  Google Scholar 

  38. Sherman PW, Holland E, Sherman JS (2008) Allergies: their role in cancer prevention. Q Rev Biol 83(4):339–362

    Article  PubMed  Google Scholar 

  39. Burnet M (1957) Cancer: a biological approach. III. Viruses associated with neoplastic conditions. IV. Practical applications. Br Med J 1(5023):841–847

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Profet M (1991) The function of allergy: immunological defense against toxins. Q Rev Biol 66(1):23–62

    Article  CAS  PubMed  Google Scholar 

  41. Ellison-Loschmann L, Benavente Y, Douwes J, Buendia E, Font R, Alvaro T et al (2007) Immunoglobulin E levels and risk of lymphoma in a case-control study in Spain. Cancer Epidemiol Biomark Prev 16(7):1492–1498

    Article  CAS  Google Scholar 

  42. Helby J, Bojesen SE, Nielsen SF, Nordestgaard BG (2015) IgE and risk of cancer in 37 747 individuals from the general population. Ann Oncol 26(8):1784–1790

    Article  CAS  PubMed  Google Scholar 

  43. Severson RK, Davis S, Thomas DB, Stevens RG, Heuser L, Sever LE (1989) Acute myelocytic leukemia and prior allergies. J Clin Epidemiol 42(10):995–1001

    Article  CAS  PubMed  Google Scholar 

  44. Kallen B, Gunnarskog J, Conradson TB (1993) Cancer risk in asthmatic subjects selected from hospital discharge registry. Eur Respir J 6(5):694–697

    CAS  PubMed  Google Scholar 

  45. Dikalioti SK, Chang ET, Dessypris N, Papadopoulou C, Skenderis N, Pourtsidis A et al (2012) Allergy-associated symptoms in relation to childhood non-Hodgkin’s as contrasted to Hodgkin’s lymphomas: a case-control study in Greece and meta-analysis. Eur J Cancer 48(12):1860–1866

    Article  PubMed  Google Scholar 

  46. Wigertz A, Lonn S, Schwartzbaum J, Hall P, Auvinen A, Christensen HC et al (2007) Allergic conditions and brain tumor risk. Am J Epidemiol 166(8):941–950

    Article  PubMed  Google Scholar 

  47. Wiemels JL, Wiencke JK, Sison JD, Miike R, McMillan A, Wrensch M (2002) History of allergies among adults with glioma and controls. Int J Cancer 98(4):609–615

    Article  CAS  PubMed  Google Scholar 

  48. Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M (2011) Family and personal medical history and risk of meningioma. J Neurosurg 115(6):1072–1077

    Article  PubMed  PubMed Central  Google Scholar 

  49. Turner MC, Krewski D, Armstrong BK, Chetrit A, Giles GG, Hours M et al (2013) Allergy and brain tumors in the INTERPHONE study: pooled results from Australia, Canada, France, Israel, and New Zealand. Cancer Causes Control 24(5):949–960

    Article  PubMed  Google Scholar 

  50. Wiemels JL, Wiencke JK, Patoka J, Moghadassi M, Chew T, McMillan A et al (2004) Reduced immunoglobulin E and allergy among adults with glioma compared with controls. Cancer Res 64(22):8468–8473

    Article  CAS  PubMed  Google Scholar 

  51. Wiemels JL, Wrensch M, Sison JD, Zhou M, Bondy M, Calvocoressi L et al (2011) Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls. Int J Cancer 129(8):1932–1939

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Wiemels JL, Wilson D, Patil C, Patoka J, McCoy L, Rice T et al (2009) IgE, allergy, and risk of glioma: update from the San Francisco Bay area adult Glioma study in the temozolomide era. Int J Cancer 125(3):680–687

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Wrensch M, Wiencke JK, Wiemels J, Miike R, Patoka J, Moghadassi M et al (2006) Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survival. Cancer Res 66(8):4531–4541

    Article  CAS  PubMed  Google Scholar 

  54. Eriksson NE, Holmen A, Hogstedt B, Mikoczy Z, Hagmar L (1995) A prospective study of cancer incidence in a cohort examined for allergy. Allergy 50(9):718–722

    Article  CAS  PubMed  Google Scholar 

  55. Hedderson MM, Malone KE, Daling JR, White E (2003) Allergy and risk of breast cancer among young women (United States). Cancer Causes Control 14(7):619–626

    Article  PubMed  Google Scholar 

  56. Hwang CY, Chen YJ, Lin MW, Chen TJ, Chu SY, Chen CC et al (2012) Cancer risk in patients with allergic rhinitis, asthma and atopic dermatitis: a nationwide cohort study in Taiwan. Int J Cancer 130(5):1160–1167

    Article  CAS  PubMed  Google Scholar 

  57. Ma W, Yang J, Li P, Lu X, Cai J (2017) Association between allergic conditions and colorectal Cancer risk/mortality: a meta-analysis of prospective studies. Sci Rep 7(1):5589

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  58. Negri E, Bosetti C, La Vecchia C, Levi F, Tomei F, Franceschi S (1999) Allergy and other selected diseases and risk of colorectal cancer. Eur J Cancer 35(13):1838–1841

    Article  CAS  PubMed  Google Scholar 

  59. Turner MC, Chen Y, Krewski D, Ghadirian P, Thun MJ, Calle EE (2005) Cancer mortality among US men and women with asthma and hay fever. Am J Epidemiol 162(3):212–221

    Article  PubMed  Google Scholar 

  60. Prizment AE, Folsom AR, Cerhan JR, Flood A, Ross JA, Anderson KE (2007) History of allergy and reduced incidence of colorectal cancer, Iowa Women’s Health Study. Cancer Epidemiol Biomark Prev 16(11):2357–2362

    Article  Google Scholar 

  61. La Vecchia C, D’Avanzo B, Negri E, Franceschi S (1991) History of selected diseases and the risk of colorectal cancer. Eur J Cancer 27(5):582–586

    Article  PubMed  Google Scholar 

  62. Vesterinen E, Pukkala E, Timonen T, Aromaa A (1993) Cancer incidence among 78,000 asthmatic patients. Int J Epidemiol 22(6):976–982

    Article  CAS  PubMed  Google Scholar 

  63. Wang H, Rothenbacher D, Low M, Stegmaier C, Brenner H, Diepgen TL (2006) Atopic diseases, immunoglobulin E and risk of cancer of the prostate, breast, lung and colorectum. Int J Cancer 119(3):695–701

    Article  PubMed  CAS  Google Scholar 

  64. Gandini S, Lowenfels AB, Jaffee EM, Armstrong TD, Maisonneuve P (2005) Allergies and the risk of pancreatic cancer: a meta-analysis with review of epidemiology and biological mechanisms. Cancer Epidemiol Biomark Prev 14(8):1908–1916

    Article  Google Scholar 

  65. Olson SH, Chou JF, Ludwig E, O’Reilly E, Allen PJ, Jarnagin WR et al (2010) Allergies, obesity, other risk factors and survival from pancreatic cancer. Int J Cancer 127(10):2412–2419

    Article  CAS  PubMed  Google Scholar 

  66. Silverman DT, Schiffman M, Everhart J, Goldstein A, Lillemoe KD, Swanson GM et al (1999) Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer. Br J Cancer 80(11):1830–1837

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. La Vecchia C, Negri E, D’Avanzo B, Ferraroni M, Gramenzi A, Savoldelli R et al (1990) Medical history, diet and pancreatic cancer. Oncology 47(6):463–466

    Article  PubMed  Google Scholar 

  68. Ji J, Shu X, Li X, Sundquist K, Sundquist J, Hemminki K (2009) Cancer risk in hospitalised asthma patients. Br J Cancer 100(5):829–833

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Huang BZ, Le Marchand L, Haiman CA, Monroe KR, Wilkens LR, Zhang ZF et al (2018) Atopic allergic conditions and pancreatic cancer risk: results from the Multiethnic Cohort Study. Int J Cancer 142(10):2019–2027

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Dai Q, Zheng W, Ji BT, Shu XO, Jin F, Cheng HX et al (1997) Prior immunity-related medical conditions and oesophageal cancer risk: a population-based case-control study in Shanghai. Eur J Cancer Prev 6(2):152–157

    CAS  PubMed  Google Scholar 

  71. El-Zein M, Parent ME, Ka K, Siemiatycki J, St-Pierre Y, Rousseau MC (2010) History of asthma or eczema and cancer risk among men: a population-based case-control study in Montreal, Quebec. Can Ann Allergy Asthma Immunol 104(5):378–384

    Article  PubMed  Google Scholar 

  72. Johnson LG, Schwartz SM, Malkki M, Du Q, Petersdorf EW, Galloway DA et al (2011) Risk of cervical cancer associated with allergies and polymorphisms in genes in the chromosome 5 cytokine cluster. Cancer Epidemiol Biomark Prev 20(1):199–207

    Article  CAS  Google Scholar 

  73. Gonzalez-Perez A, Fernandez-Vidaurre C, Rueda A, Rivero E, Garcia Rodriguez LA (2006) Cancer incidence in a general population of asthma patients. Pharmacoepidemiol Drug Saf 15(2):131–138

    Article  PubMed  Google Scholar 

  74. Huovinen E, Kaprio J, Vesterinen E, Koskenvuo M (1997) Mortality of adults with asthma: a prospective cohort study. Thorax 52(1):49–54

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  75. Lim WY, Chen Y, Ali SM, Chuah KL, Eng P, Leong SS et al (2011) Polymorphisms in inflammatory pathway genes, host factors and lung cancer risk in Chinese female never-smokers. Carcinogenesis 32(4):522–529

    Article  CAS  PubMed  Google Scholar 

  76. Talbot-Smith A, Fritschi L, Divitini ML, Mallon DF, Knuiman MW (2003) Allergy, atopy, and cancer: a prospective study of the 1981 Busselton cohort. Am J Epidemiol 157(7):606–612

    Article  PubMed  Google Scholar 

  77. Arana A, Wentworth CE, Fernandez-Vidaurre C, Schlienger RG, Conde E, Arellano FM (2010) Incidence of cancer in the general population and in patients with or without atopic dermatitis in the U.K. Br J Dermatol 163(5):1036–1043

    Article  CAS  PubMed  Google Scholar 

  78. Ming ME, Levy R, Hoffstad O, Filip J, Abrams BB, Fernandez C et al (2004) The lack of a relationship between atopic dermatitis and nonmelanoma skin cancers. J Am Acad Dermatol 50(3):357–362

    Article  PubMed  Google Scholar 

  79. Pelucchi C, Naldi L, Di Landro A, La Vecchia C (2008) Oncology Study Group of Italian Group for Epidemiologic Research in D. Anthropometric measures, medical history and risk of basal cell carcinoma in an Italian case-control study. Dermatology 216(3):271–276

    Article  PubMed  Google Scholar 

  80. Kim WJ, Lee HL, Lee SC, Kim YT, Kim H (2000) Polymorphisms of N-acetyltransferase 2, glutathione S-transferase mu and theta genes as risk factors of bladder cancer in relation to asthma and tuberculosis. J Urol 164(1):209–213

    Article  CAS  PubMed  Google Scholar 

  81. Steineck G, Adolfsson J, Scher HI, Whitmore WF Jr (1995) Distinguishing prognostic and treatment-predictive information for localized prostate cancer. Urology 45(4):610–615

    Article  CAS  PubMed  Google Scholar 

  82. Hallquist A, Hardell L, Degerman A, Boquist L (1994) Thyroid cancer: reproductive factors, previous diseases, drug intake, family history and diet. A case-control study. Eur J Cancer Prev 3(6):481–488

    Article  CAS  PubMed  Google Scholar 

  83. Goedert JJ, Vitale F, Lauria C, Serraino D, Tamburini M, Montella M et al (2002) Risk factors for classical Kaposi’s sarcoma. J Natl Cancer Inst 94(22):1712–1718

    Article  CAS  PubMed  Google Scholar 

  84. Negri E, Ron E, Franceschi S, La Vecchia C, Preston-Martin S, Kolonel L et al (2002) Risk factors for medullary thyroid carcinoma: a pooled analysis. Cancer Causes Control 13(4):365–372

    Article  PubMed  Google Scholar 

  85. La Vecchia C, Negri E, D’Avanzo B, Boyle P, Franceschi S (1990) Medical history and primary liver cancer. Cancer Res 50(19):6274–6277

    PubMed  Google Scholar 

  86. Andreev K, Graser A, Maier A, Mousset S, Finotto S (2012) Therapeutical measures to control airway tolerance in asthma and lung cancer. Front Immunol 3:216

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. Akbari O, DeKruyff RH, Umetsu DT (2001) Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2(8):725–731

    Article  CAS  PubMed  Google Scholar 

  88. Raker VK, Domogalla MP, Steinbrink K (2015) Tolerogenic dendritic cells for regulatory T cell induction in man. Front Immunol 6:569

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  89. Gatault S, Delbeke M, Driss V, Sarazin A, Dendooven A, Kahn JE et al (2015) IL-18 is involved in eosinophil-mediated tumoricidal activity against a colon carcinoma cell line by upregulating LFA-1 and ICAM-1. J Immunol 195(5):2483–2492

    Article  CAS  PubMed  Google Scholar 

  90. Zaynagetdinov R, Sherrill TP, Gleaves LA, McLoed AG, Saxon JA, Habermann AC et al (2015) Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment. Cancer Res 75(8):1624–1634

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  91. Majumdar S, Ghosh A, Saha S (2018) Modulating interleukins and their receptors interactions with small chemicals using in Silico approach for asthma. Curr Top Med Chem 18(13):1123–1134

    Article  CAS  PubMed  Google Scholar 

  92. Jiang L, Shen Y, Guo D, Yang D, Liu J, Fei X et al (2016) EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance. Nat Commun 7:13045

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Khanduja KL, Kaushik G, Khanduja S, Pathak CM, Laldinpuii J, Behera D (2011) Corticosteroids affect nitric oxide generation, total free radicals production, and nitric oxide synthase activity in monocytes of asthmatic patients. Mol Cell Biochem 346(1–2):31–37

    Article  CAS  PubMed  Google Scholar 

  94. Probst HC, McCoy K, Okazaki T, Honjo T, van den Broek M (2005) Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4. Nat Immunol 6(3):280–286

    Article  CAS  PubMed  Google Scholar 

  95. Robainas M, Otano R, Bueno S, Ait-Oudhia S (2017) Understanding the role of PD-L1/PD1 pathway blockade and autophagy in cancer therapy. Onco Targets Ther 10:1803–1807

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  96. Rosenwald A, Wright G, Leroy K, Yu X, Gaulard P, Gascoyne RD et al (2003) Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J Exp Med 198(6):851–862

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Singh AK, Stock P, Akbari O (2011) Role of PD-L1 and PD-L2 in allergic diseases and asthma. Allergy 66(2):155–162

    Article  CAS  PubMed  Google Scholar 

  98. Munthe-Kaas MC, Carlsen KH, Helms PJ, Gerritsen J, Whyte M, Feijen M et al (2004) CTLA-4 polymorphisms in allergy and asthma and the TH1/TH2 paradigm. J Allergy Clin Immunol 114(2):280–287

    Article  CAS  PubMed  Google Scholar 

  99. Bertrand A, Kostine M, Barnetche T, Truchetet ME, Schaeverbeke T (2015) Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis. BMC Med 13:211

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  100. Hellings PW, Vandenberghe P, Kasran A, Coorevits L, Overbergh L, Mathieu C et al (2002) Blockade of CTLA-4 enhances allergic sensitization and eosinophilic airway inflammation in genetically predisposed mice. Eur J Immunol 32(2):585–594

    Article  CAS  PubMed  Google Scholar 

  101. Saul L, Ilieva KM, Bax HJ, Karagiannis P, Correa I, Rodriguez-Hernandez I et al (2016) IgG subclass switching and clonal expansion in cutaneous melanoma and normal skin. Sci Rep 6:29736

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Harshyne LA, Nasca BJ, Kenyon LC, Andrews DW, Hooper DC (2016) Serum exosomes and cytokines promote a T-helper cell type 2 environment in the peripheral blood of glioblastoma patients. Neuro-Oncology 18(2):206–215

    Article  CAS  PubMed  Google Scholar 

  103. Ribatti D (2016) Mast cells as therapeutic target in cancer. Eur J Pharmacol 778:152–157

    Article  CAS  PubMed  Google Scholar 

  104. Akdis M, Akdis CA (2014) Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens. J Allergy Clin Immunol 133(3):621–631

    Article  CAS  PubMed  Google Scholar 

  105. Lippi G, Meschi T, Nouvenne A, Mattiuzzi C, Borghi L (2014) Neutrophil gelatinase-associated lipocalin in cancer. Adv Clin Chem 64:179–219

    Article  CAS  PubMed  Google Scholar 

  106. Wen CP, Lee JH, Tai YP, Wen C, Wu SB, Tsai MK et al (2014) High serum iron is associated with increased cancer risk. Cancer Res 74(22):6589–6597

    Article  CAS  PubMed  Google Scholar 

  107. Li H, Zhang K, Liu LH, Ouyang Y, Bu J, Guo HB et al (2014) A systematic review of matrix metalloproteinase 9 as a biomarker of survival in patients with osteosarcoma. Tumour Biol 35(6):5487–5491

    Article  CAS  PubMed  Google Scholar 

  108. Maio M, Coukos G, Ferrone S, Fox BA, Fridman WH, Garcia PL et al (2019) Addressing current challenges and future directions in immuno-oncology: expert perspectives from the 2017 NIBIT Foundation Think Tank, Siena, Italy. Cancer Immunol Immunother 68(1):1–9

    Article  PubMed  Google Scholar 

  109. Walsh NC, Kenney LL, Jangalwe S, Aryee KE, Greiner DL, Brehm MA et al (2017) Humanized mouse models of clinical disease. Annu Rev Pathol 12:187–215

    Article  CAS  PubMed  Google Scholar 

  110. Jensen-Jarolim E, Einhorn L, Herrmann I, Thalhammer JG, Panakova L (2015) Pollen allergies in humans and their dogs, cats and horses: differences and similarities. Clin Transl Allergy 5:15

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  111. Jensen-Jarolim E, Achatz G, Turner MC, Karagiannis S, Legrand F, Capron M et al (2008) AllergoOncology: the role of IgE-mediated allergy in cancer. Allergy 63(10):1255–1266

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Bioinformatics, Bose Institute, Kolkata, India

    Sreyashi Majumdar & Sudipto Saha

Authors
  1. Sreyashi Majumdar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sudipto Saha
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sudipto Saha .

Editor information

Editors and Affiliations

  1. National Centre for Cell Science, Pune, Maharashtra, India

    Shailza Singh

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Majumdar, S., Saha, S. (2020). Systems Immunology Approach in Understanding the Association of Allergy and Cancer. In: Singh, S. (eds) Systems and Synthetic Immunology . Springer, Singapore. https://doi.org/10.1007/978-981-15-3350-1_2

Download citation

Publish with us

Policies and ethics

Search

Navigation