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Vaccine Design, Nanoparticle Vaccines and Biomaterial Applications

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Systems and Synthetic Immunology

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Abstract

Leishmaniasis is a neglected tropical disease subverting the immune system of the infected individual. Most of available treatment regimens are associated with various drawbacks such as drug resistance, toxicity, and cost. Development and implementation of vaccines seem to be the only rationale to eradicate the disease. However, various traditional approaches for vaccine development have been implicated against leishmaniasis, but till date, no vaccine is available for humans in the market. It has been observed that vaccination strategy including live or attenuated vaccines is mainly due to their ability to deliver the antigens to the appropriate immune cells for generating an immune response. This indicates that pan-Leishmania vaccine packaged into a suitable delivery system could not only increase the stability of the vaccine candidate but also lead to its targeted delivery which will mimic the natural infection and recognition of the antigen by the desired antigen-presenting cells. Various natural and synthetic polymers have been used as delivery vehicles encapsulating the vaccine components against leishmaniasis. Herein, we have tried to summarize such attempts, along with our insight on using synthetic circuits as delivery system, not only for targeted but also controlling the expression dynamics of antigen as needed.

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    Pragya Misra & Shailza Singh

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    Shailza Singh

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Misra, P., Singh, S. (2020). Vaccine Design, Nanoparticle Vaccines and Biomaterial Applications. In: Singh, S. (eds) Systems and Synthetic Immunology . Springer, Singapore. https://doi.org/10.1007/978-981-15-3350-1_1

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