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Microbial Production of Antibiotics Using Metabolic Engineering

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Engineering of Microbial Biosynthetic Pathways

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Abstract

Metabolic engineering is an advanced production technology to produce novel antibiotic factories by enabling development of high-performance engineered microbial strains. Since, antibiotic yield and productivity are the keen design parameters therefore in metabolic engineering main focus is directed on the carbon flux to increase the antibiotic yield. To achieve this goal, various approaches like genetic modifications, heterologous production, and metabolic alterations are introduced which resulted in substantial elevation of the existing conventional production processes of antibiotics. This book chapter deals with current state of art in metabolic engineering for higher yield of antibiotics.

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Authors and Affiliations

  1. Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, India

    Sonam Gupta, Payal Gupta & Vikas Pruthi

  2. Department of Biotechnology, National Institute of Technology Raipur, Raipur, Chhattisgarh, India

    Sonam Gupta

Authors
  1. Sonam Gupta
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  2. Payal Gupta
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  3. Vikas Pruthi
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Editor information

Editors and Affiliations

  1. Department of Biosciences, School of Science, Indrashil University, Mehsana, Gujarat, India

    Vijai Singh

  2. Department of Food Process Engineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, Uttar Pradesh, India

    Ajay Kumar Singh

  3. Gujarat Biotechnology Research Center, Department of Science and Technology, Gandhinagar, Gujarat, India

    Poonam Bhargava

  4. Gujarat Biotechnology Research Center, Department of Science and Technology, Gandhinagar, Gujarat, India

    Madhvi Joshi

  5. Gujarat Biotechnology Research Center, Department of Science and Technology, Gandhinagar, Gujarat, India

    Chaitanya G. Joshi

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Gupta, S., Gupta, P., Pruthi, V. (2020). Microbial Production of Antibiotics Using Metabolic Engineering. In: Singh, V., Singh, A., Bhargava, P., Joshi, M., Joshi, C. (eds) Engineering of Microbial Biosynthetic Pathways. Springer, Singapore. https://doi.org/10.1007/978-981-15-2604-6_13

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