Abstract
Fertility is a concern for the majority of young men and women diagnosed with cancer, though many will face infertility as a consequence of surgery, chemotherapy, radiation therapy, and delayed childbearing. Fertility concerns can impact quality of life as well as treatment decisions, adherence to therapy, and possibly survival. Therefore, fertility preservation is an important aspect of comprehensive cancer care for young men and women. Recent advances in fertility preservation techniques, such as oocyte, embryo, and ovarian tissue cryopreservation, have expanded the options available to prepubescent girls and young women, though long-term outcome data is limited. While semen cryopreservation is an established option for men, advances in testicular tissue cryopreservation may lead to an option for prepubescent boys. Future advances will expand our understanding of the risk of infertility with newer cancer therapies and the long-term safety and efficacy of current fertility options. In addition, the possibility of in vitro maturation of gametes and the development of artificial gametes may create options for individuals with cancer who are unable to bank gametes prior to treatment.
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References
Llarena NC, Estevez SL, Tucker SL, Jeruss JS. Impact of fertility concerns on tamoxifen initiation and persistence. J Natl Cancer Inst. 2015;107(10):djv202.
Martinez F. International Society for Fertility Preservation–ESHRE–ASRM Expert Working Group. Update on fertility preservation from the Barcelona International Society for Fertility Preservation-ESHRE-ASRM 2015 expert meeting: indications, results and future perspectives. Fertil Steril. 2017;108(3):407–15.
Donnez J, Dolmans MM. Fertility preservation in women. Nat Rev Endocrinol. 2013 Dec;9(12):735–49.
Denschlag D, Reed NS, Rodolakis A. Fertility-sparing approaches in gynecologic cancers: a review of ESGO task force activities. Curr Oncol Rep. 2012 Dec;14(6):535–8.
Ogilvy-Stuart AL, Shalet SM. Effect of radiation on the human reproductive system. Environ Health Perspect. 1993;1010(2):109–16.
Lin W, Titus S, Moy F, Ginsburg ES, Oktay K. Ovarian aging in women with BRCA germline mutations. J Clin Endocrinol Metab. 2017 Oct 1;102(10):3839–47.
https://www.teamlivestrong.org/we-can-help/fertility-services/risks/ Accessed 5 Jan 2018.
Cakmak H, Katz A, Cedars MI, Rosen MP. Effective method for emergency fertility preservation: random-start controlled ovarian stimulation. Fertil Steril. 2013;100(6):1673–80.
Baynosa J, Westphal LM, Madrigrano A, Wapnir I. Timing of breast cancer treatments with oocyte retrieval and embryo cryopreservation. J Am Coll Surg. 2009;209:603–7.
Oktay K, Hourvitz A, Sahin G, Oktem O, Safro B, Cil A, Bang H. Letrozole reduces estrogen and gonadotropin exposure in women with breast cancer undergoing ovarian stimulation before chemotherapy. J Clin Endocrinol Metab. 2006;91(10):3885–90.
Azim A, Costantini-Ferrando M, Oktay K. Safety of fertility preservation by ovarian stimulation with letrozole and gonadotropins in patients with breast cancer: a prospective controlled study. J Clin Oncol. 2008;26(16):2630–5.
Anderson RA, Kinniburgh D, Baird D. Preliminary experience of the use of a gonadotrophin-releasing hormone antagonist in ovulation induction/in-vitro fertilization prior to cancer treatment. Hum Reprod. 1999;14(10):2665–8.
Bastings L, Beerendonk CC, Westphal JR, et al. Autotransplantation of cryopreserved ovarian tissue in cancer survivors and the risk of reintroducing malignancy: a systematic review. Hum Reprod Update. 2013;19:483–506.
Smitz J, Dolmans MM, Donnez J, et al. Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation. Hum Reprod Update. 2010;16:395–414.
Prasath EB, Chan ML, Wong WH, Lim CJ, Tharmalingam MD, Hendricks M, et al. First pregnancy and live birth resulting from cryopreserved embryos obtained from in vitro matured oocytes after oophorectomy in an ovarian cancer patient. Hum Reprod. 2014;29:276–8.
Oktay K, Turan V, Bedoschi G, Pacheco FS, Moy F. Fertility preservation success subsequent to concurrent aromatase inhibitor treatment and ovarian stimulation in women with breast Cancer. J Clin Oncol. 2015 Aug 1;33(22):2424–9.
Pacheco F, Oktay K. Current success and efficiency of autologous ovarian transplantation: a meta-analysis. Reprod Sci. 2017 Aug;24(8):1111–20.
Demeestere I, Simon P, Dedeken L, Moffa F, Tsépélidis S, Brachet C, Delbaere A, Devreker F, Ferster A. Live birth after autograft of ovarian tissue cryopreserved during childhood. Hum Reprod. 2015 Sep;30(9):2107–9.
Lambertini M, Ceppi M, Poggio F, Peccatori FA, Azim HA Jr, Ugolini D, Pronzato P, Loibl S, Moore HC, Partridge AH, Bruzzi P, Del Mastro L. Ovarian suppression using luteinizing hormone-releasing hormone agonists during chemotherapy to preserve ovarian function and fertility of breast cancer patients: a meta-analysis of randomized studies. Ann Oncol. 2015;26(12):2408–19.
Ethics Committee of ASRM. Fertility preservation and reproduction in patients facing gonadotoxic therapies: a committee opinion. Fertil Steril. 2013;100(5):1224–31.
Loren AW, Mangu PB, Beck LN, Brennan L, Magdalinski AJ, Partridge AH, Quinn G, Wallace WH, Oktay K, American Society of Clinical Oncology. Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2013;31(19):2500–10.
Holoch P, Wald M. Current options for preservation of fertility in the male. Fertil Steril. 2011 Aug;96(2):286–90.
Furuhashi K, Ishikawa T, Hashimoto H, Yamada S, Ogata S, Mizusawa Y, Matsumoto Y, Okamoto E, Kokeguchi S, Shiotani M. Onco-testicular sperm extraction: testicular sperm extraction in azoospermic and very severely oligozoospermic cancer patients. Andrologia. 2013 Apr;45(2):107–10.
García A, Herrero MB, Holzer H, Tulandi T, Chan P. Assisted reproductive outcomes of male cancer survivors. J Cancer Surviv. 2015 Jun;9(2):208–14.
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Shah, S., Vitek, W. (2020). Recent Advances in Fertility Preservation. In: Allahbadia, G.N., Ata, B., Lindheim, S.R., Woodward, B.J., Bhagavath, B. (eds) Textbook of Assisted Reproduction. Springer, Singapore. https://doi.org/10.1007/978-981-15-2377-9_60
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DOI: https://doi.org/10.1007/978-981-15-2377-9_60
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