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Role of Matrix Metalloproteinases in Colorectal Cancer

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Theranostics Approaches to Gastric and Colon Cancer

Part of the book series: Diagnostics and Therapeutic Advances in GI Malignancies ((DTAGIM))

Abstract

Colorectal cancer or CRC is amongst the top three leading causes of cancer related fatalities in the US. Advanced stages of CRC have very restricted treatment options. Matrix metalloproteinases (MMPs) are vital to maintain extracellular homeostasis, however, they play an important in CRC invasion and progression. Activities of MMP1, MMP2, MMP3, MMP7, MMP9, MMP13, and MT1-MMP are overexpressed in CRC and associated with worse results, whereas activities of MMP12 is known to be protective. Therefore, MMPs have become an important therapeutic target. Earlier clinical trials by broad-spectrum inhibitors of MMP have proven to be unsuccessful due to off-target toxicity as well as lack of efficiency. Currently, safe and selective inhibitors have transformed its therapeutic ability to target MMPs.

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Abbreviations

CRC:

Colorectal cancer

MMP:

Matrix metalloproteinases

TIMP:

Tissue Inhibitors of Metalloproteinase

mRNA:

microRNA

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Authors and Affiliations

  1. Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Neha Merchant, Gayathri Chalikonda & Ganji Purnachandra Nagaraju

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  1. Neha Merchant
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  2. Gayathri Chalikonda
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  3. Ganji Purnachandra Nagaraju
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Correspondence to Ganji Purnachandra Nagaraju .

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Editors and Affiliations

  1. Department of Energy and Materials Engineering, Dongguk University-Seoul, Jung-gu, Seoul, Korea (Republic of)

    Ganji Seeta Rama Raju

  2. Guru Ghasidas University, Bilaspur, Chhattisgarh, India

    L.V.K.S. Bhaskar

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Merchant, N., Chalikonda, G., Nagaraju, G.P. (2020). Role of Matrix Metalloproteinases in Colorectal Cancer. In: Raju, G., Bhaskar, L. (eds) Theranostics Approaches to Gastric and Colon Cancer. Diagnostics and Therapeutic Advances in GI Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-15-2017-4_3

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