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Effects of Exercise on the Immune Function, Quality of Life, and Mental Health in HIV/AIDS Individuals

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 1228)

Abstract

Physical exercise is a common type of planned physical activity in order to enhance or maintain a person’s physical fitness. Physical exercise may act as an effective strategy to take control of certain conditions associated with HIV-1 infection. HIV infection and its related treatments not only affect the immune system but also cause several musculoskeletal disorders including pre-sarcopenia or sarcopenia, myalgia, and low bone mineral density. Moderate- to high-intensity aerobic exercise, progressive resistance exercise, or a combination of both is considered as a complementary part of medical care and treatment of HIV-infected individuals. In the present chapter, the results of recent investigations regarding the effects of physical activity on muscle strength and function, mental health, and immune system of HIV infected individuals will be discussed.

Keywords

  • Exercise
  • HIV
  • AIDS
  • Immune function
  • Quality of life
  • Mental health

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References

  1. Scevola D, Di Matteo A, Lanzarini P, Uberti F, Scevola S, Bernini V, Spoladore G, Faga A (2003) Effect of exercise and strength training on cardiovascular status in HIV-infected patients receiving highly active antiretroviral therapy. AIDS 17:S123–S129

    CrossRef  Google Scholar 

  2. Mellins CA, Malee KM (2013) Understanding the mental health of youth living with perinatal HIV infection: lessons learned and current challenges. J Int AIDS Soc 16(1):18593

    CrossRef  Google Scholar 

  3. Gomes-Neto M, Conceicao CS, Carvalho VO, Brites C (2013) A systematic review of the effects of different types of therapeutic exercise on physiologic and functional measurements in patients with HIV/AIDS. Clinics 68(8):1157–1167

    CrossRef  Google Scholar 

  4. Yahiaoui A, McGough EL, Voss JG (2012) Development of evidence-based exercise recommendations for older HIV-infected patients. J Assoc Nurses AIDS Care 23(3):204–219

    CrossRef  Google Scholar 

  5. Pedersen BK, Saltin B (2015) Exercise as medicine—evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports 25:1–72

    CrossRef  Google Scholar 

  6. Neto MG, Conceição CS, Carvalho VO, Brites C (2015) Effects of combined aerobic and resistance exercise on exercise capacity, muscle strength and quality of life in HIV-infected patients: a systematic review and meta-analysis. PLoS One 10(9):e0138066

    CrossRef  Google Scholar 

  7. Walker Harris V, Brown TT (2012) Bone loss in the HIV-infected patient: evidence, clinical implications, and treatment strategies. J Infect Dis 205(suppl_3):S391–S398

    CAS  CrossRef  Google Scholar 

  8. Nightingale VR, Sher TG, Hansen NB (2010) The impact of receiving an HIV diagnosis and cognitive processing on psychological distress and posttraumatic growth. J Trauma Stress 23(4):452–460

    CrossRef  Google Scholar 

  9. Kamitani E, Sipe TA, Higa DH, Mullins MM, Soares J, CDC HIV/AIDS Prevention Research Synthesis (PRS) Project (2017) Evaluating the effectiveness of physical exercise interventions in persons living with HIV: overview of systematic reviews. AIDS Educ Prev 29(4):347–363

    CrossRef  Google Scholar 

  10. Quigley A, O’Brien K, Parker R, MacKay-Lyons M (2019) Exercise and cognitive function in people living with HIV: a scoping review. Disabil Rehabil 41(12):1384–1395. https://doi.org/10.1080/09638288.2018.1432079

  11. Jaggers JR (2018) Exercise and positive living in human immunodeficiency virus/AIDS. Nurs Clin N Am 53(1):1–11

    CrossRef  Google Scholar 

  12. Vancampfort D, Mugisha J, Richards J, De Hert M, Probst M, Stubbs B (2018) Physical activity correlates in people living with HIV/AIDS: a systematic review of 45 studies. Disabil Rehabil 40(14):1618–1629

    CrossRef  Google Scholar 

  13. Mabweazara SZ, Ley C, Leach LL (2018) Physical activity, social support and socio-economic status amongst persons living with HIV and AIDS: a review. Afr J AIDS Res 17(2):203–212

    CrossRef  Google Scholar 

  14. Simpson RJ, Kunz H, Agha N, Graff R (2015) Exercise and the regulation of immune functions. Prog Mol Biol Transl Sci 135:355–380

    CAS  CrossRef  Google Scholar 

  15. Dianatinasab M, Fararouei M, Padehban V, Dianatinasab A, Alimohamadi Y, Beheshti S, AminiLari Z, AminiLari M (2018) The effect of a 12-week combinational exercise program on CD4 count and mental health among HIV infected women: a randomized control trial. J Exerc Sci Fit 16(1):21–25

    CrossRef  Google Scholar 

  16. Garcia A, Fraga GA, Vieira RC Jr, Silva CMS, Trombeta JCDS, Navalta JW, Prestes J, Voltarelli FA (2014) Effects of combined exercise training on immunological, physical and biochemical parameters in individuals with HIV/AIDS. J Sports Sci 32(8):785–792

    CrossRef  Google Scholar 

  17. Jaggers JR, Hand GA (2016) Health benefits of exercise for people living with HIV: a review of the literature. Am J Lifestyle Med 10(3):184–192

    CrossRef  Google Scholar 

  18. Vancampfort D, Stubbs B, Mugisha J (2018) Physical activity and HIV in sub-Saharan Africa: a systematic review of correlates and levels. Afr Health Sci 18(2):394–406

    CrossRef  Google Scholar 

  19. Ezema C, Onwunali A, Lamina S, Ezugwu U, Amaeze A, Nwankwo M (2014) Effect of aerobic exercise training on cardiovascular parameters and CD4 cell count of people living with human immunodeficiency virus/acquired immune deficiency syndrome: a randomized controlled trial. Niger J Clin Pract 17(5):543–548

    CAS  CrossRef  Google Scholar 

  20. Grace JM, Semple SJ, Combrink S (2015) Exercise therapy for human immunodeficiency virus/AIDS patients: guidelines for clinical exercise therapists. J Exerc Sci Fit 13(1):49–56

    CrossRef  Google Scholar 

  21. Shah KN, Majeed Z, Yoruk YB, Yang H, Hilton TN, McMahon JM, Hall WJ, Walck D, Luque AE, Ryan RM (2016) Enhancing physical function in HIV-infected older adults: a randomized controlled clinical trial. Health Psychol 35(6):563

    CrossRef  Google Scholar 

  22. dos Santos I, de Azevedo K, Silveira A, Leitão J, Bento T, Dantas PS, de Medeiros H, Knackfuss MI (2017) Physical activity and sleep of persons living with HIV/AIDS: a systematic review. Rev Andal Med Deporte 10(1):19–24

    CrossRef  Google Scholar 

  23. Fazeli PL, Marquine MJ, Dufour C, Henry BL, Montoya J, Gouaux B, Moore RC, Letendre SL, Woods SP, Grant I (2015) Physical activity is associated with better neurocognitive and everyday functioning among older adults with HIV disease. AIDS Behav 19(8):1470–1477

    CrossRef  Google Scholar 

  24. Dufour CA, Marquine MJ, Fazeli PL, Henry BL, Ellis RJ, Grant I, Moore DJ, HNRP Group (2013) Physical exercise is associated with less neurocognitive impairment among HIV-infected adults. J Neurovirol 19(5):410–417

    CrossRef  Google Scholar 

  25. Safeek RH, Hall KS, Lobelo F, del Rio C, Khoury AL, Wong T, Morey MC, McKellar MS (2018) Low levels of physical activity among older persons living with HIV/AIDS are associated with poor physical function. AIDS Res Hum Retrovir 34(11):929–935

    CAS  CrossRef  Google Scholar 

  26. Namisango E, Harding R, Atuhaire L, Ddungu H, Katabira E, Muwanika FR, Powell RA (2012) Pain among ambulatory HIV/AIDS patients: multicenter study of prevalence, intensity, associated factors, and effect. J Pain 13(7):704–713

    CrossRef  Google Scholar 

  27. Mkandla K, Myezwa H, Musenge E (2016) The effects of progressive-resisted exercises on muscle strength and health-related quality of life in persons with HIV-related poly-neuropathy in Zimbabwe. AIDS Care 28(5):639–643

    CrossRef  Google Scholar 

  28. Dudgeon WD, Jaggers JR, Phillips KD, Durstine JL, Burgess SE, Lyerly GW, Davis JM, Hand GA (2012) Moderate-intensity exercise improves body composition and improves physiological markers of stress in HIV-infected men. ISRN AIDS 2012:145127

    CrossRef  Google Scholar 

  29. American College of Sports Medicine (2003) ACM fitness book. Human Kinetics, Champaign

    Google Scholar 

  30. Nguyen AL, Lake JE, Reid MC, Glasner S, Jenkins J, Candelario J, Soliman S, del Pino HE, Moore AA (2017) Attitudes towards exercise among substance using older adults living with HIV and chronic pain. AIDS Care 29(9):1149–1152

    CrossRef  Google Scholar 

  31. Heissel A, Zech P, Rapp MA, Schuch FB, Lawrence JB, Kangas M, Heinzel S (2019) Effects of exercise on depression and anxiety in persons living with HIV: a meta-analysis. J Psychosom Res 126:109823

    CrossRef  Google Scholar 

  32. Naoroibam R, Metri KG, Bhargav H, Nagaratna R, Nagendra H (2016) Effect of Integrated Yoga (IY) on psychological states and CD4 counts of HIV-1 infected Patients: a Randomized controlled pilot study. Int J Yoga 9(1):57

    CrossRef  Google Scholar 

  33. Herek GM, Saha S, Burack J (2013) Stigma and psychological distress in people with HIV/AIDS. Basic Appl Soc Psychol 35(1):41–54

    CrossRef  Google Scholar 

  34. Monroe AK, Zhang L, Jacobson LP, Plankey MW, Brown TT, Miller EN, Martin E, Becker JT, Levine AJ, Ragin A, Sacktor NC (2017) The association between physical activity and cognition in men with and without HIV infection. HIV Med 18(8):555–563

    CAS  CrossRef  Google Scholar 

  35. Nosrat S, Whitworth JW, Ciccolo JT (2017) Exercise and mental health of people living with HIV: a systematic review. Chronic Illn 13(4):299–319

    CrossRef  Google Scholar 

  36. Simonik A, Vader K, Ellis D, Kesbian D, Leung P, Jachyra P, Carusone SC, O'Brien KK (2016) Are you ready? Exploring readiness to engage in exercise among people living with HIV and multimorbidity in Toronto, Canada: a qualitative study. BMJ Open 6(3):e010029

    CrossRef  Google Scholar 

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Correspondence to Mostafa Dianatinasab .

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Dianatinasab, M., Ghahri, S., Dianatinasab, A., Amanat, S., Fararouei, M. (2020). Effects of Exercise on the Immune Function, Quality of Life, and Mental Health in HIV/AIDS Individuals. In: Xiao, J. (eds) Physical Exercise for Human Health. Advances in Experimental Medicine and Biology, vol 1228. Springer, Singapore. https://doi.org/10.1007/978-981-15-1792-1_28

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