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Exercise and Chronic Pain

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 1228)

Abstract

In this chapter, we describe the impact and etiology of chronic pain, the associated changes in the nervous system, and the mechanisms by which exercise may be able to affect and reverse these changes. Evidence for efficacy of exercise in different conditions associated with chronic pain is presented, with focus on chronic low back pain, fibromyalgia, osteoarthritis, rheumatoid arthritis, and migraines. While the efficacy of exercise and level of evidence supporting it vary in different diseases, exercise has direct and indirect benefits for most patients suffering from chronic pain. Effective exercise regimens include education and cognitive restructuring to promote behavioral activation and reconceptualization of what pain means, with the goal of gradually reversing the vicious cycle of pain, inertia, sedentary behavior, and worsening disability. Long-term, consistent, individualized exercise-based treatment approaches are most likely to result in improvements in pain and function.

Keywords

  • Chronic pain
  • Fibromyalgia
  • Low back pain
  • Migraines
  • Cognitive behavioral therapy
  • Exercise
  • Kinesiophobia
  • Exercise-induced analgesia

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References

  1. Crofford LJ (2015) Chronic pain: where the body meets the brain. Trans Am Clin Climatol Assoc 126:167–183

    PubMed  PubMed Central  Google Scholar 

  2. Sluka KA, O’Donnell JM, Danielson J, Rasmussen A (2012) Regular physical activity prevents development of chronic pain and activation of central neurons. J Appl Physiol 114(6):725–733

    CrossRef  PubMed  PubMed Central  CAS  Google Scholar 

  3. Moseley GL, Butler DS (2015) Fifteen years of explaining pain: the past, present and future. Am Pain Soc 16(9):807–813

    CrossRef  Google Scholar 

  4. Steingrimsdottir OA, Landmark T, Macfarlane G, Nielsen CS (2017) Defining chronic pain in epidemiological studies: a systematic review and meta-analysis. Pain 158(11):2092–2107

    CrossRef  PubMed  Google Scholar 

  5. Clauw DJ (2015) Diagnosis and treating chronic musculoskeletal pain based on the underlying mechanism(s). Best Pract Res Clin Rheumatol 29(1):6–19

    CrossRef  PubMed  Google Scholar 

  6. Ambrose KR, Golightly YM (2015) Physical exercise as non-pharmacological treatment of chronic pain: why and when. Best Pract Res Clin Rheumatol 29(1):120–130

    CrossRef  PubMed  PubMed Central  Google Scholar 

  7. Mansfield K, Sim J, Jordan JL, Jordan KP (2016) A systematic review and meta-analysis of the prevalence of chronic widespread pain in the general population. Pain 157(1):55–64

    CrossRef  PubMed  Google Scholar 

  8. Schneiderhan J, Claw D, Schwenk T (2017) Primary care of patients with chronic pain. J Am Med Assoc 317(23):2368

    CrossRef  Google Scholar 

  9. Fillingim RB, Bruehl S, Dworkin RH, Dworkin SF, Loeser JD, Turk DC, Widerstrom-Noga E, Arnold L, Bennett R, Edwards RR, Freeman R, Gewandter J, Hertz S, Hochberg M, Krane E, Mantyh PW, Markman J, Neogi T, Ohrbach R, Paice J, Porreca F, Rappaport BA, Smith SM, Smith TJ, Sullivan MD, Verne N, Wasan AD, Wesselmann U (2014) The ACTTION-American Pain Society Pain Taxonomy (AAPT): an evidence-based and multi-dimensional approach to classifying chronic pain conditions. J Pain 15(3):241–249

    CrossRef  PubMed  PubMed Central  Google Scholar 

  10. Paley CA, Johnson MI (2016) Physical activity to reduce systemic inflammation associated with chronic pain and obesity. Clin J Pain 32(4):365–370

    CrossRef  PubMed  Google Scholar 

  11. Tajerian M, Clark JD (2017) Nonpharmacological interventions in targeting pain-related plasticity. Neural Plast 2017:2038573

    CrossRef  PubMed  PubMed Central  CAS  Google Scholar 

  12. Aitken D, Buchbinder R, Jones G, Winzenberg T (2015) Interventions to improve adherence to exercise for chronic musculoskeletal pain in adults. Aust Fam Physician 44(1–2):39–42

    PubMed  Google Scholar 

  13. Puentedura EJ, Flynn T (2016) Combining manual therapy with pain neuroscience education in the treatment of chronic low back pain: a narrative review of the literature. Physiother Theory Pract 32(5):408–414

    CrossRef  PubMed  Google Scholar 

  14. Cooper MA, Kluding PM, Wright DE (2016) Emerging relationships between exercise, sensory nerves, and neuropathic pain. Front Neurosci 10:372

    CrossRef  PubMed  PubMed Central  Google Scholar 

  15. Nijs J, Lluch GE, Lundberg M, Malfliet A, Sterline M (2015) Exercise therapy for chronic musculoskeletal pain: innovation by altering pain memories. Man Ther 20(1):216–220

    CrossRef  PubMed  Google Scholar 

  16. Eller-Smith OC, Nicol AL, Christianson JA (2018) Potential mechanisms and underlying centralized pain and emerging therapeutic interventions. Front Cell Neurosci 12(35):1–18

    Google Scholar 

  17. Descalzi G, Ikegami D, Ushijima T, Nestler E, Zachariou V, Narita M (2015) Epigenetic mechanisms of chronic pain. Trends Neurosci 38(4):237–246

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  18. Nijs J, Kosek E, Van Oosterwijck JV, Meeus M (2012) Dysfunctional endogenous analgesia during exercise in patients with chronic pain: to exercise or not to exercise? Pain Physician 15(3):ES205–ES213

    PubMed  Google Scholar 

  19. Daenen L, Varkey E, Kellmann M, Nijs J (2015) Exercise, not to exercise, or how to exercise in patients with chronic pain? Applying science to pain. Clin J Pain 31(2):108–114

    CrossRef  PubMed  Google Scholar 

  20. Booth J, Moseley GL, Schiltenwolf M, Cashin A, Davies M, Hubscher M (2017) Exercise for chronic musculoskeletal pain: a biopsychosocial approach. Musculoskeletal Care 15(4):413–421

    CrossRef  PubMed  Google Scholar 

  21. Kroll HR (2015) Exercise therapy for chronic pain. Phys Med Rehabil Clin N Am 26:263–281

    CrossRef  PubMed  Google Scholar 

  22. Sluka KA, Frey-Law L, Bement MH (2018) Exercise-induced pain and analgesia? Underlying mechanisms and clinical translation. Pain 159(9):91–97

    CrossRef  Google Scholar 

  23. Naugle KM, Fillingim RB, Riley J (2012) A meta-analytic review of the hypoalgesic effects of exercise. J Pain 13(12):1139–1150

    CrossRef  PubMed  PubMed Central  Google Scholar 

  24. Patrick N, Emanski E, Knaub MA (2014) Acute and chronic low back pain. Med Clin N Am 98(4):777–789

    CrossRef  PubMed  Google Scholar 

  25. Golob AL, Wipf JE (2014) Low back pain. Med Clin N Am 98(3):405–428

    CrossRef  PubMed  Google Scholar 

  26. Chou R, Deyo R, Friedly J, Skelly A, Hashimoto R, Weimer M, Fu R, Dana T, Kraegel P, Griffin J, Grusing S, Brodt ED (2017) Nonpharmacologic therapies for low back pain: a systematic review for an American College of Physicians Clinical Practice Guideline. Ann Intern Med 166(7):493–505

    CrossRef  PubMed  Google Scholar 

  27. Miyamoto GC, Lin C-WC, Cabral CMN, Van Dongen JM, Van Tulder MW (2019) Cost-effectiveness of exercise therapy in the treatment of non-specific neck pain and low back pain: a systematic review with meta-analysis. Br J Sports Med 53(3):172–181

    CrossRef  PubMed  Google Scholar 

  28. Wieland LS, Skoetz N, Pilkington K, Vempati R, R’Adamo R, Berman BM (2018) Yoga treatment for chronic non-specific low back pain. Cochrane Database Syst Rev 1:CD010671

    Google Scholar 

  29. Lin HT, Hung WC, Hung JL, Wu PS, Liaw LJ, Chang JH (2016) Effects of Pilates on patients with chronic non-specific low back pain: a systematic review. J Phys Ther Sci 28(10):2961–2969

    CrossRef  PubMed  PubMed Central  Google Scholar 

  30. Tschentscher M, Niederseer D, Niebauer J (2013) Health benefits of Nordic walking: a systematic review. Am J Prev Med 44(1):76–84

    CrossRef  PubMed  Google Scholar 

  31. Sitthipornvorakul E, Klinsophon T, Sihawong R, Janwantanakul P (2018) The effects of walking intervention in patients with chronic low back pain: a meta-analysis of randomized controlled trials. Musculoskelet Sci Pract 34:38–46

    CrossRef  PubMed  Google Scholar 

  32. Lawford BK, Walters J, Ferrar K (2016) Does walking improve disability status, function, or quality of life in adults with chronic low back pain? A systematic review. Clin Rehabil 30(6):523–536

    CrossRef  PubMed  Google Scholar 

  33. Coulombe BK, Games KE, Neil ER, Eberman LE (2017) Core stability exercise versus general exercise for chronic low back pain. J Athl Train 52(1):71–72

    CrossRef  PubMed  PubMed Central  Google Scholar 

  34. Saragiotto BT, Maher CG, Yamato TP, Costa OP, Costa LCM, Ostelo RWJG, Macedo LG (2016) Motor control exercise for nonspecific low back pain: a Cochrane review. Spine 41(16):1284–1295

    CrossRef  PubMed  Google Scholar 

  35. Sahrmann S (2002) Diagnosis and treatment of movement impairment syndromes. Mosby, St Louis, MO

    Google Scholar 

  36. Luomajoki HA, Beltran MBB, Careddu S, Bauer CM (2018) Effectiveness of movement control exercise on patients with non-specific low back pain and movement control impairment: a systematic review and meta-analysis. Musculoskelet Sci Pract 36:1–11

    CrossRef  PubMed  Google Scholar 

  37. Parreira P, Heymans MW, Van Tulder MW, Esmail R, Koes BW, Poquet N, Lin CWC, Maher CG (2017) Back Schools for chronic non-specific low back pain. Cochrane Database Syst Rev 8:CD011674

    PubMed  Google Scholar 

  38. Straube S, Harden M, Schroder H, Arendacka B, Fan X, Moore RA, Friede T (2016) Back schools for the treatment of chronic low back pain: possibility of benefit but no convincing evidence after 47 years of research - systematic review and meta-analysis. Pain 157(10):2160–2172

    CrossRef  PubMed  PubMed Central  Google Scholar 

  39. Gordon R, Bloxham S (2016) A systematic review of the effects of exercise and physical activity on non-specific chronic low back pain. Healthcare 4(2):22

    CrossRef  PubMed Central  Google Scholar 

  40. Urquhart DM, Berry P, Wluka AE, Strauss BJ, Wang Y, Proietto J, Jones G, Dixon JB, Cicuttini FM (2011) Young investigator award winner: increased fat mass is associated with high levels of low back pain intensity and disability. Spine 36(16):1320–1325

    CrossRef  PubMed  Google Scholar 

  41. Wasser J, Vasilopoulos T, Zdziarski LA, Vincent HK (2017) Exercise benefits for chronic low back pain in overweight and obese individuals. Phys Med Rehabil 9(2):181–192

    Google Scholar 

  42. Kuss K, Becker A, Quint S, Loenhardt C (2015) Activating therapy modalities in older individuals with chronic non-specific low back pain: a systematic review. Physiotherapy 101(4):310–318

    CrossRef  CAS  PubMed  Google Scholar 

  43. Foster NE, Anema JR, Cherkin D, Chou R, Cohen SP, Gross DP, Ferreira PH, Fritz JM, Koes BW, Peul W, Turner JA, Maher CG (2018) Prevention and treatment of low back pain: evidence, challenges, and promising directions. Lancet 391(10137):2368–2383

    CrossRef  PubMed  Google Scholar 

  44. Shiri R, Falah-Hassani K (2017) Does leisure time physical activity protect against low back pain? Systematic review and meta-analysis of 36 prospective cohort studies. Br J Sports Med 51(19):1410–1418

    CrossRef  PubMed  Google Scholar 

  45. Alanazi MH, Parent EC, Dennett E (2018) Effect of stabilization exercise on back pain, disability and quality of life in adults with scoliosis: a systematic review. Eur J Phys Rehabil Med 54(5):647–653

    CrossRef  PubMed  Google Scholar 

  46. Karahan AY, Sahin N, Baskent A (2017) Comparison of effectiveness of different exercise programs in treatment of failed back surgery syndrome: a randomized controlled trial. J Back Musculoskelet Rehabil 30(1):109–120

    CrossRef  Google Scholar 

  47. Rihn JA, Radcliff K, Norvell DC, Eastlack R, Phillips FM, Berland D, Sherry N, Freedman M, Vaccaro AR (2017) Comparative effectiveness of treatments for chronic low back pain. Clin Spine Surg 30(5):204–225

    CrossRef  PubMed  Google Scholar 

  48. Skelly AC, Chou R, Dettori JR, Turner JA, Friedly JL, Rundell SD, Fu R, Brodt ED, Wasson N, Winter C, Ferguson AJR (2018) Noninvasive nonpharmacological treatment for chronic pain: a systematic review. AHRQ Publication No.: 18-EHC013-EF

    Google Scholar 

  49. Gross AR, Paquin JP, Dupont G, Blanchette S, Lalonde P, Cristie T, Graham N, Kay TM, Burnie SJ, Gelley G, Goldsmith CH, Forget M, Santaguida PL, Yee AJ, Radisic GG, Hoving JL, Bronfort G, Cervical Overview Group (2016) Exercises for mechanical neck disorders: a Cochrane review update. Man Ther 24:25–45

    CrossRef  CAS  PubMed  Google Scholar 

  50. Arimi SA, Bandpei MAM, Javanshir K, Rezasoltani A, Biglarian A (2017) The effect of different exercise programs on size and function of deep cervical flexor muscles in patients with chronic nonspecific neck pain. Am J Phys Med Rehabil 96(8):582–588

    CrossRef  Google Scholar 

  51. Cheng CH, Su HT, Yen LW, Liu WY, Cheng HYK (2015) Long-term effects of therapeutic exercise on nonspecific chronic neck pain: a literature review. J Phys Ther Sci 27(4):1271–1276

    CrossRef  PubMed  PubMed Central  Google Scholar 

  52. Pereira D, Ramos E, Branco J (2015) Osteoarthritis. Acta Medica Port 28(1):99–106

    CrossRef  Google Scholar 

  53. Richter K, Muller-Ladner U, Dischereit G, Uwe L (2018) Potentials and limits of physiotherapy in osteoarthritis. Curr Rheumatol Rev 14(2):117–122

    CrossRef  PubMed  Google Scholar 

  54. Lespasio MJ, Piuzzi NS, Hushni ME, Muschler GF, Guarion A, Mont MA (2017) Knee osteoarthritis: a primer. Perm J 21:16–183

    PubMed  PubMed Central  Google Scholar 

  55. McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, Hawker GA, Henrotin Y, Hunter DJ, Kawaguchi H, Kwoh K, Lohmader S, Rannou F, Roos EM, Underwood M (2014) OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthr Cartil 22(3):363–388

    CrossRef  CAS  Google Scholar 

  56. Hochberg MC, Altman RD, April KT, Benkhati M, Guyatt G, McGowan J, Towheed T, Welch V, Wells G, Tugwell P, American College of Rheumatology (2012) American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res 64(4):465–474

    CrossRef  CAS  Google Scholar 

  57. Fransen M, McConnell S, Harmer AR, Van der Esch M, Simic M, Bennell KL (2015) Exercise for osteoarthritis of the knee. Cochrane Database Syst Rev 1:CD004376

    PubMed  Google Scholar 

  58. Bartholdy C, Juhl C, Christensen R, Lund H, Zhang W, Henriksen M (2017) The role of muscle strengthening in exercise therapy for knee osteoarthritis: a systematic review and meta-regression analysis of randomized trials. Semin Arthritis Rheum 47(1):9–21

    CrossRef  PubMed  Google Scholar 

  59. Zhang Y, Huang L, Su Y, Zhan Z, Li Y, Lai X (2017) The effects of traditional Chinese exercise in treating knee osteoarthritis: a systematic review and meta-analysis. PLoS One 12(1):e0170237

    CrossRef  PubMed  PubMed Central  CAS  Google Scholar 

  60. Chen YW, Hunt MA, Campbell KL, Peill K, Reid WD (2016) The effect of Tai Chi on four chronic conditions- cancer, osteoarthritis, heart failure and chronic obstructive pulmonary disease: a systematic review and meta-analyses. Br J Sports Med 50(7):397–407

    CrossRef  PubMed  Google Scholar 

  61. Brosseau L, Taki J, Desjardins B, Thevenot O, Fransen M, Wells GA, Imoto AM, Toupin-April K, Westby M, Gallardo ICA, Gifford W, Laferriere L, Rahman P, Loew L, Angelis G, Cavallo S, Shallwani SM, Aburub A, Bennel KL, Van der Esch M, Simic M, McConnell S, Harmer A, Kenny GP, Paterson G, Regnaux JP, Lefevre-Colau MM, McLean L (2017) The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part one: introduction, and mind-body exercise programs. Clin Rehabil 31(5):582–595

    CrossRef  PubMed  Google Scholar 

  62. Health Quality Ontario (2018) Structured education and neuromuscular exercise program for hp and/or knee osteoarthritis: a health technology assessment. Ont Health Technol Assess Ser 18(8):1–110

    Google Scholar 

  63. Bjordal JM, Johansen O, Holm I, Zapffe K, Nilsen EM (2004) The effectiveness of physical therapy, restricted to electrotherapy and exercise, for osteoarthritis of the knee. Report from Kunnskapssenteret no. 7-2004. Norwegian Knowledge Centre for the Health Services, Oslo

    Google Scholar 

  64. Alentorn-Geli E, Samuelsson K, Musahl V, Green CL, Bhandari M, Karlsson J (2017) The association of recreational and competitive running with hip and knee osteoarthritis: a systematic review and meta-analysis. J Orthop Sports Phys Ther 47(6):373–390

    CrossRef  PubMed  Google Scholar 

  65. Timmins KA, Leech RD, Batt ME, Edwards KL (2016) Running and knee osteoarthritis: a systematic review and meta-analysis. Am J Sports Med 45(6):1447–1457

    CrossRef  PubMed  Google Scholar 

  66. Nguyen C, Lefevre-Colau MM, Poiraudeau S, Rannou F (2016) Rehabilitation (exercise and strength training) and osteoarthritis: a critical narrative review. Ann Phys Rehabil Med 59(3):190–195

    CrossRef  PubMed  Google Scholar 

  67. Lespasio MJ, Sultan AA, Piuzzi NS, Khlopas A, Husni ME, Muschler GF, Mont MA (2018) Hip osteoarthritis: a primer. Perm J 22:17–084

    PubMed  PubMed Central  Google Scholar 

  68. Ceballos-Laita L, Estebanez-de-Miguel E, Martin-Nieto G, Bueno-Gracia E, Fortun-Agud M, Jimenez-del-Barrio S (2019) Effects of non-pharmacological conservative treatment on pain, range of motion and physical function in patients with mild to moderate hip osteoarthritis. A systematic review. Complement Ther Med 42:214–222

    CrossRef  PubMed  Google Scholar 

  69. Wijnen A, Bouma SE, Seeber GH, Van Der Woude LHV, Buistra SK, Lazovic D, Stevens M, Van den Akker-Scheek I (2018) The therapeutic validity and effectiveness of physiotherapeutic exercise following total hip arthroplasty for osteoarthritis: a systematic review. PLoS One 13(3):e0194517

    CrossRef  PubMed  PubMed Central  CAS  Google Scholar 

  70. Osteras N, Kjeken I, Smedslund G, Moe RH, Slatkowsky-Christensen B, Uhlig T, Hagen KB (2017) Exercise for hand osteoarthritis: a Cochrane systematic review. J Rheumatol 44(12):1850–1858

    CrossRef  PubMed  Google Scholar 

  71. Button K, Roos PE, Spasic I, Adamson P, van Deursen RWM (2015) The clinical effectiveness of self-care interventions with an exercise component to manage knee conditions: a systematic review. Knee 22:360–371

    CrossRef  PubMed  PubMed Central  Google Scholar 

  72. Kelley GA, Kelley KS, Callahan LF (2018) Community-deliverable exercise and anxiety in adults with arthritis and other rheumatic diseases: a systematic review with meta-analysis of randomized controlled trials. BMJ Open 8(2):e019138

    CrossRef  PubMed  PubMed Central  Google Scholar 

  73. Kelley GA, Kelley KS, Hootman JM (2015) Effects of exercise on depression in adults with arthritis: a systematic review with meta-analysis of randomized controlled trials. Arthritis Res Ther 17(1):21

    CrossRef  PubMed  PubMed Central  Google Scholar 

  74. Briani RV, Ferreira AS, Pazzinatto MF, Pappas E, De Oliveira Silva D, De Azevedo FM (2018) What interventions can improve quality of life or psychosocial factors of individuals with knee osteoarthritis? A systematic review with meta-analysis of primary outcomes from randomized controlled trials. Br J Sports Med 52:1031–1038

    CrossRef  PubMed  Google Scholar 

  75. Bricca A, Juhl CB, Grodzinsky AJ, Roos EM (2017) Impact of a daily exercise dose on knee joint cartilage – a systematic review and meta-analysis of randomized controlled trials in health animals. Osteoarthr Cartil 25(2017):1223–1237

    CrossRef  CAS  Google Scholar 

  76. Bricca A, Juhl CB, Steultjens M, Wirth W, Roos EM (2018) Impact of exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis: a systematic review of randomized controlled trials. Br J Sports Med 53(15):940–947

    CrossRef  PubMed  Google Scholar 

  77. Van Ginckel A, Hall M, Dobson F, Calders P (2018) Effects of long-term exercise therapy on knee joint structure in people with knee osteoarthritis: a systematic review and meta-analysis. Semin Arthritis Rheum 48(6):941–949

    CrossRef  PubMed  Google Scholar 

  78. Scott DL, Wolfe F, Huizinga TWJ (2010) Rheumatoid arthritis. Lancet 376:1094–1108

    CrossRef  PubMed  Google Scholar 

  79. McWilliams DF, Walsh DA (2017) Pain mechanisms in rheumatoid arthritis. Clin Exp Rheumatol 35:S94–S101

    Google Scholar 

  80. Mills JA, Pinals RS, Ropes MW, Cl S, Sutcliffe J (1971) Value of bed rest in patients with rheumatoid arthritis. N Engl J Med 284(9):453–458

    CrossRef  CAS  PubMed  Google Scholar 

  81. Hurkmans E, Van der Giesen FJ, Vliet Vlieland TPM, Schoones J, Van den Ende ECHM (2009) Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid arthritis. Cochrane Database Syst Rev 4:CD006853

    Google Scholar 

  82. Han A, Judd M, Welch V, Wu T, Tugwell P, wells GA (2004) Tai chi for treating rheumatoid arthritis. Cochrane Database Syst Rev 3:CD004849

    Google Scholar 

  83. Lee MS, Pittler MH, Ernst E (2007) Tai chi for rheumatoid arthritis: systematic review. Rheumatology 46:1648–1651

    CrossRef  CAS  PubMed  Google Scholar 

  84. Williams MA, Srikesavan C, Heine PJ, Brosseau BJ, Hoxey-Thomas N, Lamb SE (2018) Exercise for rheumatoid arthritis of the hand. Cochrane Database Syst Rev 7:CD003832

    PubMed  Google Scholar 

  85. Daien CI, Hua C, Combe B, Landewe R (2017) Non-pharmacological and pharmacological interventions in patients with early arthritis: a systematic literature review informing the 2016 update of EULAR recommendations for the management of early arthritis. RMD Open 3:e000404

    CrossRef  PubMed  PubMed Central  Google Scholar 

  86. Ward MM, Deodhar A, Aki EA, Lui A, Ermann J, Gensler LS, Smith JA, Borenstein JA, Hiratzka J, Weiss PF, Inman RD, Majithia V, Haroon N, Maksymowych WP, Joyce J, Clark BM, Colbert RA, Figgie M, Hallegua DS, Prete PE, Rosenbaum JT, Stebulis JA, Van den Bosch F, Yu DTY, Miller AS, Reveille JD, Caplan L (2016) American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network 2015 recommendations for the treatment of ankylosing spondylitis and nonradiographic axial spondyloarthritis. Arthritis Rheum 68(2):282–298

    CrossRef  Google Scholar 

  87. Millner JR, Barron JS, Beinke JM, Butterworth RH, Chasle BE, Dutton LJ, Lewington MA, Lim EG, Morley TB, O’Reilly JE, Pickering KA, Winzenberg T, Zochling J (2016) Exercise for ankylosing spondylitis: an evidence-based consensus statement. Semin Arthritis Rheum 45(4):411–427

    CrossRef  PubMed  Google Scholar 

  88. Sosa-Reina MD, Nunez-Nagy S, Gallego-Izquierdo T, Pecos-Martin D, Monserrat J, Alvarez-Mon M (2017) Effectiveness of therapeutic exercise in fibromyalgia syndrome: a systematic review and meta-analysis of randomized clinical trials. Biomed Res Int 2017:2356346

    CrossRef  PubMed  PubMed Central  Google Scholar 

  89. Andrade A, de Steffens AK, Sieczkowska SM, Tartaruga LAP, Vilarino GT (2018) A systematic review of the effects of strength training in patients with fibromyalgia: clinical outcomes and design considerations. Adv Rheumatol 58:36–50

    CrossRef  PubMed  Google Scholar 

  90. Bidonde J, Busch AJ, Bath B, Milosavljevic S (2014) Exercise for adults with fibromyalgia: an umbrella systematic review with synthesis of best evidence. Curr Rheumatol Rev 10(1):45–79

    CrossRef  PubMed  Google Scholar 

  91. Andrade A, Vilarino GT, Sieczkowska SM, Coimbra DR, De Azevedo Klumb Steffens R, Vietta GG (2018) Acute effects of physical exercises on the inflammatory markers of patients with fibromyalgia syndrome: a systematic review. J Neuroimmunol 316:40–49

    CrossRef  CAS  PubMed  Google Scholar 

  92. Sharif K, Watad A, Brgazzi NL, Lichtbroun M, Amital H, Shoenfeld Y (2018) Physical activity and autoimmune diseases: get moving and manage the disease. Autoimmun Rev 17(1):53–72

    CrossRef  CAS  PubMed  Google Scholar 

  93. Nelson NL (2015) Muscle strengthening activities and fibromyalgia: a review of pain and strength outcomes. J Bodyw Mov Ther 19(2):370–376

    CrossRef  PubMed  Google Scholar 

  94. Till SR, Wahl HN, As-Sanie S (2017) The role of nonpharmacologic therapies in management of chronic pelvic pain: what to do when surgery fails. Curr Opin Obstet Gynecol 29(4):231–239

    CrossRef  PubMed  Google Scholar 

  95. Goncalves AV, Barros NF, Bahamondes L (2017) The practice of hatha yoga for treatment of pain associated with endometriosis. J Altern Complement Med 23(1):45–52

    CrossRef  PubMed  Google Scholar 

  96. Saxena R, Gupta M, Shankar N, Jain S, Saxena A (2017) Effects of yogic intervention on pain scores and quality of life in females with chronic pelvic pain. Int J Yoga 10(1):9–15

    CrossRef  PubMed  PubMed Central  Google Scholar 

  97. Rosenberg L, Butler N, Seng EK (2018) Health behaviors in episodic migraine: why behavior change matters. Curr Pain Headache Rep 22(10):65

    CrossRef  PubMed  Google Scholar 

  98. Amin FM, Aristeidou S, Baraldi C, Czapinska-Ciepiela EK, Ariadni DD, Di Lenola D, Fenech C, Kampouris K, Karagiorgis G, Braschinsky M, Linde M (2018) European Headache Federation School of Advanced Studies (EHF-SAS) the association between migraine and physical exercise. J Headache Pain 19:83

    CrossRef  PubMed  PubMed Central  Google Scholar 

  99. Luedtke K, Allers A, Schulte LH, May A (2016) Efficacy of interventions used by physiotherapists for patients with headache and migraine – systematic review and meta-analysis. Cephalalgia 36(5):474–492

    CrossRef  PubMed  Google Scholar 

  100. Irby MB, Bond DS, Lipton RB, Nicklas B, Houle RR, Penzien DB (2016) Aerobic exercise for reducing migraine burden: mechanisms, markers, and models of change processes. Headache 56(2):357–369

    CrossRef  PubMed  Google Scholar 

  101. Klenofsky B, Pace A, Natbony LR, Sheikh HU (2019) Episodic migraine comorbidities: avoiding pitfalls and taking therapeutic opportunities. Curr Pain Headache Rep 23(1):1

    CrossRef  PubMed  Google Scholar 

  102. French DJ, Holroyd KA, Pinell C, Malinoski PT, O’Donnell F, Hill KR (2000) Perceived self-efficacy and headache-related disability. Headache 40(8):647–656

    CrossRef  CAS  PubMed  Google Scholar 

  103. Lehto SM, Tolmunen T, Joensuu M, Saarinen PI, Valkonen-Korhonen M, Vanninen R, Ahola P, Tiihonen J, Lehtonen J (2008) Changes in midbrain serotonin transporter availability in atypically depressed subjects after one year of psychotherapy. Prog Neuro-Psychopharmacol Biol Psychiatry 32(1):229–237

    CrossRef  CAS  Google Scholar 

  104. Bernard P, Romain AJ, Caudroit J, Chevance G, Carayol M, Gourlan M, Needham Dancause K, Moullec G (2018) Cognitive behavior therapy combined with exercise for adults with chronic diseases: systematic review and meta-analysis. Health Psychol 37(5):433–450

    CrossRef  PubMed  Google Scholar 

  105. Piette JD, Richardson C, Himle J, Duffy S, Torres T, Vogel M, Barber K, Valenstein M (2011) A randomized trial of telephonic counseling plus walking for depressed diabetes patients. Med Care 49(7):641–648

    CrossRef  PubMed  PubMed Central  Google Scholar 

  106. McBeth J, Prescott G, Scotland G, Lovell K, Keeley P, Hannaford P, McNamee P, Symmons DP, Woby S, Gkazinou C, Beasley M, Macfarlane GJ (2012) Cognitive behavior therapy, exercise, or both for treating chronic widespread pain. Arch Intern Med 172(1):48–57

    CrossRef  PubMed  Google Scholar 

  107. Meyer C, Denies CM, Berquin AD (2018) Secondary prevention of chronic musculoskeletal pain: a systematic review of clinical trials. Ann Phys Rehabil Med 61(5):323–338

    CrossRef  PubMed  Google Scholar 

  108. Van Koulil S, Effting M, Kraaimaat FW, van Lankeld W, van Helmond T, Cats H, van Riel PL, de Jong AJ, Haverman JF, Evers AW (2007) Cognitive-behavioural therapies and exercise programmes for patients with fibromyalgia: state of the art and future directions. Ann Rheum Dis 66(5):571–581

    CrossRef  PubMed  Google Scholar 

  109. Keel PJ, Bodoky C, Gerhard U, Müller W (1999) Comparison of integrated group therapy and group relaxation training for fibromyalgia. Surv Anesthesiol 43(5):300

    CrossRef  Google Scholar 

  110. Lemstra M, Olszynski WP (2005) The effectiveness of multidisciplinary rehabilitation in the treatment of fibromyalgia. Clin J Pain 21(2):166–174

    CrossRef  PubMed  Google Scholar 

  111. Little P, Lewith G, Webley F, Evans M, Beattie A, Middleton K, Barnett J, Ballard K, Oxford F, Smith P, Yardley L, Hollinghurst S, Sharp D (2008) Randomised controlled trial of Alexander technique lessons, exercise, and massage (ATEAM) for chronic and recurrent back pain. Br J Sports Med 42(12):965–968

    PubMed  Google Scholar 

  112. Mackey S (2014) National pain strategy task force: the strategic plan for the IOM pain report. Pain Med 15(7):1070–1071

    CrossRef  PubMed  Google Scholar 

  113. Thieme K, Gromnica-Ihle E, Flor H (2003) Operant behavioral treatment of fibromyalgia: a controlled study. Arthritis Rheum 49(3):314–320

    CrossRef  PubMed  Google Scholar 

  114. Snelgrove S, Liossi C (2013) Living with chronic low back pain: a metasynthesis of qualitative research. Chronic Illn 9(4):283–301

    CrossRef  PubMed  Google Scholar 

  115. Vlaeyen J, Linton S (2000) Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Pain 85:317–332

    CrossRef  CAS  PubMed  Google Scholar 

  116. Wertli MM, Rasmussen-Barr E, Held U, Weiser S, Bachmann LM, Brunner F (2014) Fear-avoidance beliefs – a moderator of treatment efficacy in patients with low back pain: a systematic review. Spine J 14(11):2658–2678

    CrossRef  PubMed  Google Scholar 

  117. Nelson N, Churilla J (2015) Physical activity, fear avoidance, and chronic non-specific pain: a narrative review. J Bodyw Mov Ther 19(3):494–499

    CrossRef  PubMed  Google Scholar 

  118. Larsson A, Palstam A, Lofgren M, Ernberg M, Bjersing J, Bileviciute-Ljungar I, Gerdle B, Kosek E, Mannerkorpi K (2017) Pain and fear avoidance partially mediate change in muscle strength during resistance exercise in women with fibromyalgia. J Rehabil Med 49(9):744–750

    CrossRef  PubMed  Google Scholar 

  119. Parker R, Bergman E, Mntambo A, Stubbs S, Wills M (2017) Levels of physical activity in people with chronic pain. S Afr J Physiother 73(1):a323

    CrossRef  Google Scholar 

  120. McBeth J, Nicholl BI, Cordingley L, Davies KA, Macfarlane GJ (2010) Chronic widespread pain predicts physical inactivity: results from the prospective EPIFUND study. Eur J Pain 14(9):972–979

    CrossRef  PubMed  PubMed Central  Google Scholar 

  121. Nijs J, Roussel N, Van Oosterwijck H, De Kooning M, Ickmans K, Struyf F, Meeus M, Lundberg M (2013) Fear of movement and avoidance behavior toward physical activity in chronic-fatigue syndrome and fibromyalgia: state of the art and implications for clinical practice. Clin Rheumatol 32(8):1121–1129

    CrossRef  PubMed  Google Scholar 

  122. Smith BE, Hendrick P, Smith TO, Bateman M, Moffatt F, Rathleff MS, Selfe J, Logan P (2017) Should exercises be painful in the management of chronic musculoskeletal pain? A systematic review and meta-analysis. Br J Sports Med 51(23):1679–1687

    CrossRef  PubMed  Google Scholar 

  123. Palstam A, Larsson A, Lofgren M, Ernberg M, Bjersing J, Bileviciute-Ljungar I, Gerdle B, Kosek E, Mannerkorpi K (2016) Decrease of fear avoidance beliefs following person-centered progressive resistance exercise contributes to reduced pain disability in women with fibromyalgia: secondary exploratory analyses form a randomized controlled trial. Arthritis Res Ther 18:116

    CrossRef  PubMed  PubMed Central  Google Scholar 

  124. Nicolson PA, Bennell KL, Dobson FL, Van Ginckel A, Holden MA, Hinman RS (2017) Interventions to increase adherence to therapeutic exercise in older adults with low back pain and/or hip/knee osteoarthritis: a systematic review and meta-analysis. Br J Sports Med 51(10):791–799

    CrossRef  PubMed  Google Scholar 

  125. Picorelli AMA, Pereira LSM, Preira DS, Felicio D, Sherrington C (2014) Adherence to exercise programs for older people is influenced by program characteristics and personal factors: a systematic review. J Physiother 60(3):151–156

    CrossRef  PubMed  Google Scholar 

  126. Schultze R, Rees C, Smith A, Slater H, Campbell JM, O’Sullivan P (2018) How can we best reduce pain catastrophizing in adults with chronic noncancer pain? A systematic review and meta-analysis. J Pain 19(3):233–256

    CrossRef  Google Scholar 

  127. Lopez-de-Uralde-Villanueva I, Munoz-Garcia D, Gil-Martinez A, Pardo-Montero J, Munoz-Plata R, Angulo-Diaz-Parreno S, Gomez-Martinez M, La Touche R (2016) A systematic review and meta-analysis on the effectiveness of graded activity and graded exposure for chronic nonspecific low back pain. Pain Med 17(1):172–188

    PubMed  Google Scholar 

  128. McGrane N, Galvin R, Cusack T, Stokes E (2015) Addition of motivational interventions to exercise and traditional physiotherapy: a review and meta-analysis. Physiotherapy 101(1):1–12

    CrossRef  CAS  PubMed  Google Scholar 

  129. Hurley M, Dickson K, Hallet R, Grant R, Hauari H, Wlash N, Stansfield C, Oliver S (2018) Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review. Cochrane Database Syst Rev 4:CD010842

    PubMed  Google Scholar 

  130. Gay C, Chabaud A, Guilley E, Coudeyre E (2016) Educating patients about the benefits of physical activity and exercise for their hip and knee osteoarthritis. Systematic literature review. Ann Phys Rehabil Med 59(3):174–183

    CrossRef  CAS  PubMed  Google Scholar 

  131. Yazigi F, Espanha M, Marques A, Teles J, Teixeira P (2018) Predictors of walking capacity in obese adults with knee osteoarthritis. Acta Reumatol Port 43(4):256–263

    PubMed  Google Scholar 

  132. Lima LV, Abner TS, Sluka KA (2017) Does exercise increase or decrease pain? Central mechanisms underlying these two phenomena. J Physiol 595(13):4141–4150

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  133. Zdziarski LA, Wasser JG, Vincent HK (2015) Chronic pain management in the obese patient: a focused review of key challenges and potential exercise solutions. J Pain Res 8:63–77

    PubMed  PubMed Central  Google Scholar 

  134. Paolucci T, Saraceni VM, Piccinini G (2016) Management of chronic pain in osteoporosis: challenges and solutions. J Pain Res 9:177–186

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  135. Joelsson M, Bernhardsson S, Larsson MEH (2017) Patients with chronic pain may need extra support when prescribed physical activity in primary care: a qualitative study. Scand J Prim Health Care 35(1):64074

    CrossRef  Google Scholar 

  136. Kolt GS, McEvoy JF (2003) Adherence to rehabilitation in patients with low back pain. Man Ther 8:110–116

    CrossRef  CAS  PubMed  Google Scholar 

  137. Slade S, Patel S, Underwood M, Keating JL (2014) What are patient beliefs and perceptions about exercise for nonspecific chronic low back pain? A systematic review of qualitative studies. Clin J Pain 30(11):995–1005

    CrossRef  PubMed  Google Scholar 

  138. Marley J, Tully MA, Prter-Armstrong A, Bunting B, O’Hanlon J, Atkins L, Howes S, McDonough SM (2017) The effectiveness of interventions aimed at increasing physical activity in adults with persistent musculoskeletal pain: a systematic review and meta-analysis. BMC Musculoskelet Disord 18:482

    CrossRef  PubMed  PubMed Central  Google Scholar 

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Borisovskaya, A., Chmelik, E., Karnik, A. (2020). Exercise and Chronic Pain. In: Xiao, J. (eds) Physical Exercise for Human Health. Advances in Experimental Medicine and Biology, vol 1228. Springer, Singapore. https://doi.org/10.1007/978-981-15-1792-1_16

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