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Microbial Pathogenesis: Virus Pathogen–Host Interactions

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Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery

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Abstract

Any microorganism which is capable of bringing illness in a host organism is termed as pathogen. Pathogens manipulate the cellular mechanisms of host organisms via pathogen–host interactions (PHIs) in order to take advantage of the capabilities of host cells, leading to infections. This chapter is restricted to human viral pathogens, though plant and animal pathogens are also extensive in nature. When a pathogenic microorganism (especially virus) infects the human host, a fight develops between the host’s innate and adaptive immune systems and the pathogen’s assorted virulence mechanisms. The battle results in establishing how well the host survives and recovers. Failures in vaccine production and inadequacy in antiviral therapeutics are the recent challenges what virology researchers facing now. For years, the discipline of virology has been excessively concentrated on pathogens than host response. We are aware that host response is the determinant factor for the eventual development of the pathological outcome of the infection. Viral pandemic and epidemic infections like acquired immunodeficiency syndrome (AIDS), swine flu, dengue, and other chronic and acute infections are posing a huge threat. We are in a need to develop biological approaches with sophisticated computational strategies by understanding the components, interactions, and dynamics of a biological system in a comprehensive, quantitative, and integrative fashion.

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Authors and Affiliations

  1. Division of Blood and Vascular Biology, Department of Life Sciences, School of Life Sciences, Central University of Tamil Nadu, Tiruvarur, India

    Vinodhini Krishnakumar & Meganathan Kannan

Authors
  1. Vinodhini Krishnakumar
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  2. Meganathan Kannan
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Editor information

Editors and Affiliations

  1. Department of Microbiology School of Life Sciences, Pondicherry University, Puducherry, India

    Busi Siddhardha

  2. Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry, India

    Madhu Dyavaiah

  3. Botany and Microbiology Department, King Saud University, Riyadh, Saudi Arabia

    Asad Syed

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Krishnakumar, V., Kannan, M. (2020). Microbial Pathogenesis: Virus Pathogen–Host Interactions. In: Siddhardha, B., Dyavaiah, M., Syed, A. (eds) Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery. Springer, Singapore. https://doi.org/10.1007/978-981-15-1695-5_2

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