Abstract
To understand the effect of microorganisms on host cells, in vitro cell line studies in addition to animal studies provide translational importance in human clinical trials. For better understanding the interaction between bacteria and host cells, cultured animal cell lines and cultured human epithelial cells have extensively used for understanding the mechanisms by which bacteria induce human diseases. Cell culture models define mechanisms about the mode of interactions between bacterial virulence factors and host epithelial cell receptors. Predatory bacteria do not produce cytotoxic and inflammatory response in human cells. We described the effect of chronic exposure of Porphyromonas gingivalis and Fusobacterium nucleatum on human oral cavity squamous cell carcinoma (SCC) cell. We discussed about the bacterial virulence factors interacting with cultured epithelial cells. This may permit research leading to innovative antimicrobial therapies.
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Chattopadhyay, I. (2020). Cell Lines as In Vitro Model for Studying Microbial Pathogenesis. In: Siddhardha, B., Dyavaiah, M., Syed, A. (eds) Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery. Springer, Singapore. https://doi.org/10.1007/978-981-15-1695-5_19
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