Abstract
Phytochemicals as nutritional components have been explored for their anticancer properties. Quercetin (QT), being a chief component of different dietary products, has been widely explored for its anticancer and anti-proliferative activities on numerous cancer cell lines. Also, it is an exceptional antioxidant which plays crucial role against various human cancers. QT shows significant pro-apoptotic activity against tumor cells and thus can impede the development of various cancers in humans. Moreover, the anticancer activities of QT have been recognized in various in vitro and in vivo studies on numerous cancer cell lines and animal models. Furthermore, the toxicity of QT against cancer cells is complemented with slight or no adverse effects to normal cells. Again QT molecules have been reported with major issues including low oral bioavailability and poor aqueous solubility which makes it to be an unideal moiety for therapeutic applications. Also, the frequent gastrointestinal digestion of QT seems to be a key barrier for its clinical translations. Henceforth, to overcome these drawbacks, QT-based nanoformulations (NFs) are developed which have shown favourable results in its upregulation by the epithelial system which also improved its targeted delivery at site. Herein, in this review, we have tried to focus on various promising roles of QT-based nanoformulations alone or modified with targeted nanocarriers as an ideal agent for oncotherapy.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
WHO Reports 2018. https://www.who.int/news-room/fact-sheets/detail/cancer
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136(5):E359–E386
Plummer M, de Martel C, Vignat J, Ferlay J, Bray F, Franceschi S (2016) Global burden of cancers attributable to infections in 2012: a synthetic analysis. Lancet Glob Health 4(9):e609–e616
Nam JS, Sharma AR, Nguyen LT, Chakraborty C, Sharma G, Lee SS (2016) Application of bioactive quercetin in oncotherapy: from nutrition to nanomedicine. Molecules 21(1):E108
Rauf A, Imran M, Khan IA, Ur-Rehman M, Gilani SA, Mehmood Z, Mubarak MS (2018) Anticancer potential of quercetin: a comprehensive review. Phytother Res 32(11):2109–2130
Gibellini L, Pinti M, Nasi M, Montagna JP, De Biasi S, Roat E, Cossarizza A (2011) Quercetin and cancer chemoprevention. Evid Based Complement Alternat Med 2011:591356
Caddeo C, Diez-Sales O, Pons R, Carbone C, Ennas G, Puglisi G, Manconi M (2016) Cross-linked chitosan/liposome hybrid system for the intestinal delivery of quercetin. J Colloid Interface Sci 461:69–78
Caddeo C, Nacher A, Vassallo A, Armentano MF, Pons R, Fernandez-Busquets X, Manconi M (2016) Effect of quercetin and resveratrol co-incorporated in liposomes against inflammatory/oxidative response associated with skin cancer. Int J Pharm 513(1–2):153–163
Wang Q, Bao Y, Ahire J, Chao Y (2013) Co-encapsulation of biodegradable nanoparticles with silicon quantum dots and quercetin for monitored delivery. Adv Healthc Mater 2(3):459–466
Wang G, Wang JJ, Chen XL, Du SM, Li DS, Pei ZJ, Wu LB (2013) The JAK2/STAT3 and mitochondrial pathways are essential for quercetin nanoliposome-induced C6 glioma cell death. Cell Death Dis 4:e746
Wang G, Wang J, Luo J, Wang L, Chen X, Zhang L, Jiang S (2013) PEG2000-DPSE-coated quercetin nanoparticles remarkably enhanced anticancer effects through induced programed cell death on C6 glioma cells. J Biomed Mater Res A 101(11):3076–3085
Moussa M, Goldberg SN, Kumar G, Sawant RR, Levchenko T, Torchilin VP, Ahmed M (2014) Nanodrug-enhanced radiofrequency tumor ablation: effect of micellar or liposomal carrier on drug delivery and treatment efficacy. PLoS One 9(8):e102727
Chen SQ, Wang C, Tao S, Wang YX, Hu FQ, Yuan H (2018) Rational design of redox-responsive and P-gp-inhibitory lipid nanoparticles with high entrapment of paclitaxel for tumor therapy. Adv Healthc Mater 7(17):e1800485
Ojeda-Serna IE, Rocha-Guzman NE, Gallegos-Infante JA, Chairez-Ramirez MH, Rosas-Flores W, Perez-Martinez JD, Gonzalez-Laredo RF (2019) Water-in-oil organogel based emulsions as a tool for increasing bioaccessibility and cell permeability of poorly water-soluble nutraceuticals. Food Res Int 120:415–424
Omwenga EO, Hensel A, Shitandi A, Goycoolea FM (2018) Chitosan nanoencapsulation of flavonoids enhances their quorum sensing and biofilm formation inhibitory activities against an E.coli Top 10 biosensor. Colloids Surf B Biointerfaces 164:125–133
Balakrishnan S, Mukherjee S, Das S, Bhat FA, Raja Singh P, Patra CR, Arunakaran J (2017) Gold nanoparticles-conjugated quercetin induces apoptosis via inhibition of EGFR/PI3K/Akt-mediated pathway in breast cancer cell lines (MCF-7 and MDA-MB-231). Cell Biochem Funct 35(4):217–231
Srisa-Nga K, Mankhetkorn S, Okonogi S, Khonkarn R (2018) Delivery of superparamagnetic polymeric micelles loaded with quercetin to hepatocellular carcinoma cells. J Pharm Sci 108(2):1–11
Yuan YG, Wang YH, Xing HH, Gurunathan S (2017) Quercetin-mediated synthesis of graphene oxide-silver nanoparticle nanocomposites: a suitable alternative nanotherapy for neuroblastoma. Int J Nanomedicine 12:5819–5839
Davatgaran-Taghipour Y, Masoomzadeh S, Farzaei MH, Bahramsoltani R, Karimi-Soureh Z, Rahimi R, Abdollahi M (2017) Polyphenol nanoformulations for cancer therapy: experimental evidence and clinical perspective. Int J Nanomedicine 12:2689–2702
Kashyap D, Garg VK, Tuli HS, Yerer MB, Sak K, Sharma AK, Sandhu SS (2019) Fisetin and quercetin: promising flavonoids with chemopreventive potential. Biomolecules 9(5). https://doi.org/10.3390/biom9050174
Podhajcer OL, Friedlander M, Graziani Y (1980) Effect of liposome-encapsulated quercetin on DNA synthesis, lactate production, and cyclic adenosine 3′:5′ monophosphate level in Ehrlich ascites tumor cells. Cancer Res 40(4):1344–1350
Spector M, O’Neal S, Racker E (1980) Reconstitution of the Na+K+ pump of ehrlich ascites tumor and enhancement of efficiency by quercetin. J Biol Chem 255(12):5504–5507
Goniotaki M, Hatziantoniou S, Dimas K, Wagner M, Demetzos C (2004) Encapsulation of naturally occurring flavonoids into liposomes: physicochemical properties and biological activity against human cancer cell lines. J Pharm Pharmacol 56(10):1217–1224
Tammela P, Laitinen L, Galkin A, Wennberg T, Heczko R, Vuorela H, Vuorela P (2004) Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles. Arch Biochem Biophys 425(2):193–199
Yuan ZP, Chen LJ, Fan LY, Tang MH, Yang GL, Yang HS, Wei YQ (2006) Liposomal quercetin efficiently suppresses growth of solid tumors in murine models. Clin Cancer Res 12(10):3193–3199
Yuan ZP, Chen LJ, Wei YQ, Fan LY, Tang MH, Yang GL (2006) Nanoliposomal quercetin inhibits formation of malignant ascites of hepatocellular carcinoma. Ai Zheng 25(8):941–945
Mandal AK, Das S, Mitra M, Chakrabarti RN, Chatterjee M, Das N (2008) Vesicular flavonoid in combating diethylnitrosamine induced hepatocarcinoma in rat model. J Exp Ther Oncol 7(2):123–133
Ghosh D, Ghosh S, Sarkar S, Ghosh A, Das N, Das Saha K, Mandal AK (2010) Quercetin in vesicular delivery systems: evaluation in combating arsenic-induced acute liver toxicity associated gene expression in rat model. Chem Biol Interact 186(1):61–71
Wong MY, Chiu GN (2010) Simultaneous liposomal delivery of quercetin and vincristine for enhanced estrogen-receptor-negative breast cancer treatment. Anticancer Drugs 21(4):401–410
Ghosh S, Dungdung SR, Chowdhury ST, Mandal AK, Sarkar S, Ghosh D, Das N (2011) Encapsulation of the flavonoid quercetin with an arsenic chelator into nanocapsules enables the simultaneous delivery of hydrophobic and hydrophilic drugs with a synergistic effect against chronic arsenic accumulation and oxidative stress. Free Radic Biol Med 51(10):1893–1902
Ghosh A, Mandal AK, Sarkar S, Das N (2011) Hepatoprotective and neuroprotective activity of liposomal quercetin in combating chronic arsenic induced oxidative damage in liver and brain of rats. Drug Deliv 18(6):451–459
Wong MY, Chiu GN (2011) Liposome formulation of co-encapsulated vincristine and quercetin enhanced antitumor activity in a trastuzumab-insensitive breast tumor xenograft model. Nanomedicine (Lond) 7(6):834–840
Yang W, Ahmed M, Tasawwar B, Levchenko T, Sawant RR, Collins M, Goldberg SN (2011) Radiofrequency ablation combined with liposomal quercetin to increase tumour destruction by modulation of heat shock protein production in a small animal model. Int J Hyperthermia 27(6):527–538
Sinha R, Gadhwal MK, Joshi UJ, Srivastava S, Govil G (2012) Modifying effect of quercetin on model biomembranes: studied by molecular dynamic simulation, DSC and NMR. Int J Curr Pharm Res 4(1):70–79
Wang BL, Gao X, Men K, Qiu J, Yang B, Gou ML, Wei YQ (2012) Treating acute cystitis with biodegradable micelle-encapsulated quercetin. Int J Nanomedicine 7:2239–2247
Wang G, Wang JJ, Yang GY, Du SM, Zeng N, Li DS, Ye F (2012) Effects of quercetin nanoliposomes on C6 glioma cells through induction of type III programmed cell death. Int J Nanomedicine 7:271–280
Yang W, Ahmed M, Tasawwar B, Levchenko T, Sawant RR, Torchilin V, Goldberg SN (2012) Combination radiofrequency (RF) ablation and IV liposomal heat shock protein suppression: reduced tumor growth and increased animal endpoint survival in a small animal tumor model. J Control Release 160(2):239–244
He B, Wang X, Shi HS, Xiao WJ, Zhang J, Mu B, Wang YS (2013) Quercetin liposome sensitizes colon carcinoma to thermotherapy and thermochemotherapy in mice models. Integr Cancer Ther 12(3):264–270
Hu F, Bu YZ, Liang R, Duan RM, Wang S, Han RM, Skibsted LH (2013) Quercetin and daidzein beta-apo-14′-carotenoic acid esters as membrane antioxidants. Free Radic Res 47(5):413–421
Liu H, Xue JX, Li X, Ao R, Lu Y (2013) Quercetin liposomes protect against radiation-induced pulmonary injury in a murine model. Oncol Lett 6(2):453–459
Zheng N-G, Mo S-J, Li J-P, Wu J-L (2014) Anti-CSC effects in human esophageal squamous cell carcinomas and Eca109/9706 cells induced by nanoliposomal quercetin alone or combined with CD 133 Antiserum. Asian Pac J Cancer Prev 15(20):8679–8684
Zheng N-G, Wang J-L, Yang S-L, Wu J-L (2014) Aberrant epigenetic alteration in Eca9706 cells modulated by nanoliposomal quercetin combined with butyrate mediated via epigenetic-NF-κB signaling. Asian Pac J Cancer Prev 15(11):4539–4543
Dabbagh-Bazarbachi H, Clergeaud G, Quesada IM, Ortiz M, O’Sullivan CK, Fernandez-Larrea JB (2014) Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model. J Agric Food Chem 62(32):8085–8093
Hu J, Wang J, Wang G, Yao Z, Dang X (2016) Pharmacokinetics and antitumor efficacy of DSPE-PEG2000 polymeric liposomes loaded with quercetin and temozolomide: Analysis of their effectiveness in enhancing the chemosensitization of drug-resistant glioma cells. Int J Mol Med 37(3):690–702
Ravichandiran V, Masilamani K, Senthilnathan B, Maheshwaran A, Wong TW, Roy P (2017) Quercetin-decorated curcumin liposome design for cancer therapy: in-vitro and in-vivo studies. Curr Drug Deliv 14(8):1053–1059
Rodriguez EB, Almeda RA, Vidallon MLP, Reyes CT (2018) Enhanced bioactivity and efficient delivery of quercetin through nanoliposomal encapsulation using rice bran phospholipids. J Sci Food Agric 99(4):1980–1989
Dos Santos DM, Rocha CVJ, da Silveira EF, Marinho MAG, Rodrigues MR, Silva NO, de Lima VR (2018) In vitro anti/pro-oxidant activities of R. ferruginea extract and its effect on glioma cell viability: correlation with phenolic compound content and effects on membrane dynamics. J Membr Biol 251(2):247–261
Zhou X, Liu HY, Zhao H, Wang T (2018) RGD-modified nanoliposomes containing quercetin for lung cancer targeted treatment. Onco Targets Ther 11:5397–5405
Kruszewski M, Kusaczuk M, Kotynska J, Gal M, Kretowski R, Cechowska-Pasko M, Naumowicz M (2018) The effect of quercetin on the electrical properties of model lipid membranes and human glioblastoma cells. Bioelectrochemistry 124:133–141
Zuo J, Jiang Y, Zhang E, Chen Y, Liang Z, Zhu J, Zhen Y (2019) Synergistic effects of 7-O-geranylquercetin and siRNAs on the treatment of human breast cancer. Life Sci 227:145–152
Riaz MK, Zhang X, Wong KH, Chen H, Liu Q, Chen X, Yang Z (2019) Pulmonary delivery of transferrin receptors targeting peptide surface-functionalized liposomes augments the chemotherapeutic effect of quercetin in lung cancer therapy. Int J Nanomedicine 14:2879–2902
Soloviev AI, Kizub IV (2019) Mechanisms of vascular dysfunction evoked by ionizing radiation and possible targets for its pharmacological correction. Biochem Pharmacol 159:121–139
Yu J, Chen H, Jiang L, Wang J, Dai J, Wang J (2019) Codelivery of adriamycin and P-gp inhibitor quercetin using PEGylated liposomes to overcome cancer drug resistance. J Pharm Sci 108(5):1788–1799
Murgia S, Bonacchi S, Falchi AM, Lampis S, Lippolis V, Meli V, Caltagirone C (2013) Drug-loaded fluorescent cubosomes: versatile nanoparticles for potential theranostic applications. Langmuir 29(22):6673–6679
Minaei A, Sabzichi M, Ramezani F, Hamishehkar H, Samadi N (2016) Co-delivery with nano-quercetin enhances doxorubicin-mediated cytotoxicity against MCF-7 cells. Mol Biol Rep 43(2):99–105
Karthivashan G, Masarudin MJ, Kura AU, Abas F, Fakurazi S (2016) Optimization, formulation, and characterization of multiflavonoids-loaded flavanosome by bulk or sequential technique. Int J Nanomedicine 11:3417–3434
Babazadeh A, Zeinali M, Hamishehkar H (2018) Nano-phytosome: a developing platform for herbal anti-cancer agents in cancer therapy. Curr Drug Targets 19(2):170–180
Tavano L, Mauro L, Naimo GD, Bruno L, Picci N, Ando S, Muzzalupo R (2016) Further evolution of multifunctional niosomes based on pluronic surfactant: dual active targeting and drug combination properties. Langmuir 32(35):8926–8933
Hemati M, Haghiralsadat F, Yazdian F, Jafari F, Moradi A, Malekpour-Dehkordi Z (2019) Development and characterization of a novel cationic PEGylated niosome-encapsulated forms of doxorubicin, quercetin and siRNA for the treatment of cancer by using combination therapy. Artif Cells Nanomed Biotechnol 47(1):1295–1311
Tan Q, Liu W, Guo C, Zhai G (2011) Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery. Int J Nanomedicine 6:1621–1630
Gao X, Wang B, Wei X, Men K, Zheng F, Zhou Y, Wei Y (2012) Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer. Nanoscale 4(22):7021–7030
Xu G, Shi H, Ren L, Gou H, Gong D, Gao X, Huang N (2015) Enhancing the anti-colon cancer activity of quercetin by self-assembled micelles. Int J Nanomedicine 10:2051–2063
Wang G, Wang JJ, Chen XL, Du L, Li F (2016) Quercetin-loaded freeze-dried nanomicelles: Improving absorption and anti-glioma efficiency in vitro and in vivo. J Control Release 235:276–290
Zhao J, Liu J, Wei T, Ma X, Cheng Q, Huo S, Liang XJ (2016) Quercetin-loaded nanomicelles to circumvent human castration-resistant prostate cancer in vitro and in vivo. Nanoscale 8(9):5126–5138
Patidar P, Pillai SA, Sheth U, Bahadur P, Bahadur A (2017) Glucose triggered enhanced solubilisation, release and cytotoxicity of poorly water soluble anti-cancer drugs fromT1307 micelles. J Biotechnol 254:43–50
Rich GT, Buchweitz M, Winterbone MS, Kroon PA, Wilde PJ (2017) Towards an understanding of the low bioavailability of quercetin: a study of its interaction with intestinal lipids. Nutrients 9(2). https://doi.org/10.3390/nu9020111
Sandhu PS, Kumar R, Katare OP, Singh B (2017) Surface-tailored nanomixed micelles containing quercetin-salicylic acid physical complex for enhanced cellular and in vivo activities: a quality by design perspective. Nanomedicine (Lond) 12(11):1281–1303
Ahmad N, Ahmad R, Naqvi AA, Alam MA, Ashafaq M, Abdur Rub R, Ahmad FJ (2018) Intranasal delivery of quercetin-loaded mucoadhesive nanoemulsion for treatment of cerebral ischaemia. Artif Cells Nanomed Biotechnol 46(4):717–729
Ghosh A, Mandal AK, Sarkar S, Panda S, Das N (2009) Nanoencapsulation of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats. Life Sci 84(3–4):75–80
Ghosh A, Ghosh D, Sarkar S, Mandal AK, Thakur Choudhury S, Das N (2012) Anticarcinogenic activity of nanoencapsulated quercetin in combating diethylnitrosamine-induced hepatocarcinoma in rats. Eur J Cancer Prev 21(1):32–41
Ding B, Chen P, Kong Y, Zhai Y, Pang X, Dou J, Zhai G (2014) Preparation and evaluation of folate-modified lipid nanocapsules for quercetin delivery. J Drug Target 22(1):67–75
El-Gogary RI, Rubio N, Wang JT, Al-Jamal WT, Bourgognon M, Kafa H, Al-Jamal KT (2014) Polyethylene glycol conjugated polymeric nanocapsules for targeted delivery of quercetin to folate-expressing cancer cells in vitro and in vivo. ACS Nano 8(2):1384–1401
Mandal AK, Ghosh D, Sarkar S, Ghosh A, Swarnakar S, Das N (2014) Nanocapsulated quercetin downregulates rat hepatic MMP-13 and controls diethylnitrosamine-induced carcinoma. Nanomedicine (Lond) 9(15):2323–2337
Hatahet T, Morille M, Shamseddin A, Aubert-Pouessel A, Devoisselle JM, Begu S (2017) Dermal quercetin lipid nanocapsules: Influence of the formulation on antioxidant activity and cellular protection against hydrogen peroxide. Int J Pharm 518(1–2):167–176
Hatahet T, Morille M, Hommoss A, Devoisselle JM, Muller RH, Begu S (2018) Liposomes, lipid nanocapsules and smartCrystals(R): a comparative study for an effective quercetin delivery to the skin. Int J Pharm 542(1–2):176–185
Schwingel TE, Klein CP, Nicoletti NF, Dora CL, Hadrich G, Bica CG, Morrone FB (2014) Effects of the compounds resveratrol, rutin, quercetin, and quercetin nanoemulsion on oxaliplatin-induced hepatotoxicity and neurotoxicity in mice. Naunyn Schmiedebergs Arch Pharmacol 387(9):837–848
Pangeni R, Panthi VK, Yoon IS, Park JW (2018) Preparation, characterization, and in vivo evaluation of an oral multiple nanoemulsive system for co-delivery of pemetrexed and quercetin. Pharmaceutics 10(3). https://doi.org/10.3390/pharmaceutics10030158
Arbain NH, Salim N, Wui WT, Basri M, Rahman MBA (2018) Optimization of quercetin loaded palm oil ester based nanoemulsion formulation for pulmonary delivery. J Oleo Sci 67(8):933–940. https://doi.org/10.5650/jos.ess17253
Arbain NH, Salim N, Masoumi HRF, Wong TW, Basri M, Abdul Rahman MB (2019) In vitro evaluation of the inhalable quercetin loaded nanoemulsion for pulmonary delivery. Drug Deliv Transl Res 9(2):497–507. https://doi.org/10.1007/s13346-018-0509-5
Bose S, Du Y, Takhistov P, Michniak-Kohn B (2013) Formulation optimization and topical delivery of quercetin from solid lipid based nanosystems. Int J Pharm 441(1–2):56–66
Varshosaz J, Jafarian A, Salehi G, Zolfaghari B (2014) Comparing different sterol containing solid lipid nanoparticles for targeted delivery of quercetin in hepatocellular carcinoma. J Liposome Res 24(3):191–203
Khoee S, Rahmatolahzadeh R (2012) Synthesis and characterization of pH-responsive and folated nanoparticles based on self-assembled brush-like PLGA/PEG/AEMA copolymer with targeted cancer therapy properties: A comprehensive kinetic study. Eur J Med Chem 50:416–427
Sahu S, Saraf S, Kaur CD, Saraf S (2013) Biocompatible nanoparticles for sustained topical delivery of anticancer phytoconstituent quercetin. Pak J Biol Sci 16(13):601–609
Jain AK, Thanki K, Jain S (2013) Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity. Mol Pharm 10(9):3459–3474
Zafar S, Negi LM, Verma AK, Kumar V, Tyagi A, Singh P, Talegaonkar S (2014) Sterically stabilized polymeric nanoparticles with a combinatorial approach for multi drug resistant cancer: in vitro and in vivo investigations. Int J Pharm 477(1–2):454–468
Sharma G, Park J, Sharma AR, Jung JS, Kim H, Chakraborty C, Nam JS (2015) Methoxy poly(ethylene glycol)-poly(lactide) nanoparticles encapsulating quercetin act as an effective anticancer agent by inducing apoptosis in breast cancer. Pharm Res 32(2):723–735
David KI, Jaidev LR, Sethuraman S, Krishnan UM (2015) Dual drug loaded chitosan nanoparticles-sugar – coated arsenal against pancreatic cancer. Colloids Surf B Biointerfaces 135:689–698
Du H, Liu M, Yang X, Zhai G (2015) The role of glycyrrhetinic acid modification on preparation and evaluation of quercetin-loaded chitosan-based self-aggregates. J Colloid Interface Sci 460:87–96
Pandey SK, Patel DK, Thakur R, Mishra DP, Maiti P, Haldar C (2015) Anti-cancer evaluation of quercetin embedded PLA nanoparticles synthesized by emulsified nanoprecipitation. Int J Biol Macromol 75:521–529
Zhu X, Zeng X, Zhang X, Cao W, Wang Y, Chen H, Shi X (2016) The effects of quercetin-loaded PLGA-TPGS nanoparticles on ultraviolet B-induced skin damages in vivo. Nanomedicine (Lond) 12(3):623–632
Fatma S, Talegaonkar S, Iqbal Z, Panda AK, Negi LM, Goswami DG, Tariq M (2016) Novel flavonoid-based biodegradable nanoparticles for effective oral delivery of etoposide by P-glycoprotein modulation: an in vitro, ex vivo and in vivo investigations. Drug Deliv 23(2):500–511
Lv L, Liu C, Chen C, Yu X, Chen G, Shi Y, Li G (2016) Quercetin and doxorubicin co-encapsulated biotin receptor-targeting nanoparticles for minimizing drug resistance in breast cancer. Oncotarget 7(22):32184–32199
Guan X, Gao M, Xu H, Zhang C, Liu H, Lv L, Tian Y (2016) Quercetin-loaded poly (lactic-co-glycolic acid)-d-alpha-tocopheryl polyethylene glycol 1000 succinate nanoparticles for the targeted treatment of liver cancer. Drug Deliv 23(9):3307–3318
Saha C, Kaushik A, Das A, Pal S, Majumder D (2016) Anthracycline drugs on modified surface of quercetin-loaded polymer nanoparticles: a dual drug delivery model for cancer treatment. PLoS One 11(5):e0155710
Suksiriworapong J, Phoca K, Ngamsom S, Sripha K, Moongkarndi P, Junyaprasert VB (2016) Comparison of poly(epsilon-caprolactone) chain lengths of poly(epsilon-caprolactone)-co-d-alpha-tocopheryl-poly(ethylene glycol) 1000 succinate nanoparticles for enhancement of quercetin delivery to SKBR3 breast cancer cells. Eur J Pharm Biopharm 101:15–24
Xing L, Lyu JY, Yang Y, Cui PF, Gu LQ, Qiao JB, Jiang HL (2017) pH-Responsive de-PEGylated nanoparticles based on triphenylphosphine-quercetin self-assemblies for mitochondria-targeted cancer therapy. Chem Commun (Camb) 53(62):8790–8793
Zhu B, Yu L, Yue Q (2017) Co-delivery of vincristine and quercetin by nanocarriers for lymphoma combination chemotherapy. Biomed Pharmacother 91:287–294
Oliveira AI, Pinho C, Fonte P, Sarmento B, Dias ACP (2018) Development, characterization, antioxidant and hepatoprotective properties of poly(E-caprolactone) nanoparticles loaded with a neuroprotective fraction of Hypericum perforatum. Int J Biol Macromol 110:185–196
Baksi R, Singh DP, Borse SP, Rana R, Sharma V, Nivsarkar M (2018) In vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles. Biomed Pharmacother 106:1513–1526
Yamina AM, Fizir M, Itatahine A, He H, Dramou P (2018) Preparation of multifunctional PEG-graft-Halloysite Nanotubes for Controlled Drug Release, Tumor Cell Targeting, and Bio-imaging. Colloids Surf B Biointerfaces 170:322–329
Bishayee K, Khuda-Bukhsh AR, Huh SO (2015) PLGA-loaded gold-nanoparticles precipitated with Quercetin downregulate HDAC-Akt activities controlling proliferation and Activate p53-ROS crosstalk to induce apoptosis in hepatocarcinoma cells. Mol Cells 38(6):518–527
Lou M, Zhang LN, Ji PG, Feng FQ, Liu JH, Yang C, Wang L (2016) Quercetin nanoparticles induced autophagy and apoptosis through AKT/ERK/Caspase-3 signaling pathway in human neuroglioma cells: In vitro and in vivo. Biomed Pharmacother 84:1–9
Luo CL, Liu YQ, Wang P, Song CH, Wang KJ, Dai LP, Ye H (2016) The effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via JAK2 suppression. Biomed Pharmacother 82:595–605
Balakrishnan S, Bhat FA, Raja Singh P, Mukherjee S, Elumalai P, Das S, Arunakaran J (2016) Gold nanoparticle-conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2-mediated pathway in breast cancer. Cell Prolif 49(6):678–697
Xu MX, Wang M, Yang WW (2017) Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kappaB signaling and Nrf2 pathway in high fat diet fed mice. Int J Nanomedicine 12:327–345
Ren KW, Li YH, Wu G, Ren JZ, Lu HB, Li ZM, Han XW (2017) Quercetin nanoparticles display antitumor activity via proliferation inhibition and apoptosis induction in liver cancer cells. Int J Oncol 50(4):1299–1311
Verma NK, Crosbie-Staunton K, Satti A, Gallagher S, Ryan KB, Doody T, Gun’ko YK (2013) Magnetic core-shell nanoparticles for drug delivery by nebulization. J Nanobiotechnol 11:1
Kumar SR, Priyatharshni S, Babu VN, Mangalaraj D, Viswanathan C, Kannan S, Ponpandian N (2014) Quercetin conjugated superparamagnetic magnetite nanoparticles for in-vitro analysis of breast cancer cell lines for chemotherapy applications. J Colloid Interface Sci 436:234–242
Mashhadi Malekzadeh A, Ramazani A, Tabatabaei Rezaei SJ, Niknejad H (2017) Design and construction of multifunctional hyperbranched polymers coated magnetite nanoparticles for both targeting magnetic resonance imaging and cancer therapy. J Colloid Interface Sci 490:64–73
Mittal AK, Kumar S, Banerjee UC (2014) Quercetin and gallic acid mediated synthesis of bimetallic (silver and selenium) nanoparticles and their antitumor and antimicrobial potential. J Colloid Interface Sci 431:194–199
Martirosyan A, Grintzalis K, Polet M, Laloux L, Schneider YJ (2016) Tuning the inflammatory response to silver nanoparticles via quercetin in Caco-2 (co-)cultures as model of the human intestinal mucosa. Toxicol Lett 253:36–45
Gismondi A, Reina G, Orlanducci S, Mizzoni F, Gay S, Terranova ML, Canini A (2015) Nanodiamonds coupled with plant bioactive metabolites: a nanotech approach for cancer therapy. Biomaterials 38:22–35
Gupta P, Authimoolam SP, Hilt JZ, Dziubla TD (2015) Quercetin conjugated poly(beta-amino esters) nanogels for the treatment of cellular oxidative stress. Acta Biomater 27:194–204
Lockhart JN, Stevens DM, Beezer DB, Kravitz A, Harth E (2015) Dual drug delivery of tamoxifen and quercetin: regulated metabolism for anticancer treatment with nanosponges. J Control Release 220(Pt B):751–757
Cruz Dos Santos S, Osti Silva N, Dos Santos Espinelli JBJ, Germani Marinho MA, Vieira Borges Z, Bruzamarello Caon Branco N, Rodrigues de Lima V (2019) Molecular interactions and physico-chemical characterization of quercetin-loaded magnetoliposomes. Chem Phys Lipids 218:22–33
Alidadi H, Khorsandi L, Shirani M (2018) Effects of quercetin on tubular cell apoptosis and kidney damage in rats induced by titanium dioxide nanoparticles. Malays J Med Sci 25(2):72–81. https://doi.org/10.21315/mjms2018.25.2.8
George D, Maheswari PU, Begum K (2019) Synergic formulation of onion peel quercetin loaded chitosan-cellulose hydrogel with green zinc oxide nanoparticles towards controlled release, biocompatibility, antimicrobial and anticancer activity. Int J Biol Macromol 132:784–794
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Das, S.S., Verma, P.R.P., Kar, S., Singh, S.K. (2020). Quercetin-Loaded Nanomedicine as Oncotherapy. In: Rahman, M., Beg, S., Kumar, V., Ahmad, F. (eds) Nanomedicine for Bioactives . Springer, Singapore. https://doi.org/10.1007/978-981-15-1664-1_5
Download citation
DOI: https://doi.org/10.1007/978-981-15-1664-1_5
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-1663-4
Online ISBN: 978-981-15-1664-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)