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The Role of Synbiotics in Alleviating Oxidative Stress in Colorectal Cancer

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Role of Oxidative Stress in Pathophysiology of Diseases

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Abstract

Colorectal cancer (CRC) is one of the leading malignancies that result in high morbidity and mortality among both the genders, though the incidence is higher in females. It is a multifactorial and multistage disease. One of the major progenitors of colorectal cancer is the reactive oxygen species. A disturbance in the prooxidant-antioxidant balance in the cells leads to compromise in DNA repair mechanism, protein denaturation, lipid peroxidation, and apoptosis leading finally to tumor proliferation. Dysbiosis in the colon is a known cause of oxidative stress. This chapter aims to elucidate the role played by oxidative stress in colorectal oncogenesis. The potential palliative role of probiotics against CRC is also discussed. Probiotics have been known for possessing potent antioxidant attributes and preventing colorectal carcinogenesis. However, mechanism of action of probiotics in amelioration of oxidative stress is not very clear. Thus, the aim of the present chapter is also to review the antioxidant mechanisms of probiotics, choice of species specific to colorectal disease, and role of prebiotics in potentiating the effect of probiotics by balancing the microbiota and physicochemical conditions of colorectal milieu, in the production of anti-cancer compounds and in decreasing oxidative stress. Synbiotics, i.e., the combination of probiotics and prebiotics, are known to be an effective potential strategy in combating CRC.

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References

  1. Gandomani HS, Aghajani M, Mohammadian-Hafshejani A, Tarazoj AA, Pouyesh V, Salehiniya H (2017) Colorectal cancer in the world: incidence, mortality and risk factors. Biomed Res Ther 4(10):1656–1675

    Google Scholar 

  2. Watson AJ, Collins PD (2011) Colon cancer: a civilization disorder. Dig Dis 29(2):222–228

    PubMed  Google Scholar 

  3. Pačínková A, Popovici V (2019) Cross-platform data analysis reveals a generic gene expression signature for microsatellite instability in colorectal cancer. Biomed Res Int 2019:6763596

    PubMed  PubMed Central  Google Scholar 

  4. Vipperla K, O’Keefe SJ (2016) Diet, microbiota, and dysbiosis: a ‘recipe’ for colorectal cancer. Food Funct 7(4):1731–1740

    PubMed  PubMed Central  CAS  Google Scholar 

  5. Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357(9255):539–545

    PubMed  CAS  Google Scholar 

  6. Bartsch H, Nair J (2004) Oxidative stress and lipid peroxidation-derived DNA-lesions in inflammation driven carcinogenesis. Cancer Detect Prev 28(6):385–391

    PubMed  CAS  Google Scholar 

  7. Terzić J, Grivennikov S, Karin E, Karin M (2010) Inflammation and colon cancer. Gastroenterology 138(6):2101–2114

    PubMed  Google Scholar 

  8. Park S-Y, Wilkens LR, Setiawan VW, Monroe KR, Haiman CA, Le Marchand L (2018) Alcohol intake and colorectal cancer risk in the multiethnic cohort study. Am J Epidemiol 188(1):67–76

    PubMed Central  Google Scholar 

  9. Slattery ML, Potter J, Caan B, Edwards S, Coates A, Ma K-N et al (1997) Energy balance and colon cancer—beyond physical activity. Cancer Res 57(1):75–80

    PubMed  CAS  Google Scholar 

  10. Tamura M, Ito H, Matsui H, Hyodo I (2014) Acetaldehyde is an oxidative stressor for gastric epithelial cells. J Clin Biochem Nutr 55:26–31

    PubMed  PubMed Central  CAS  Google Scholar 

  11. Na H-K, Lee J (2017) Molecular basis of alcohol-related gastric and colon cancer. Int J Mol Sci 18(6):1116

    PubMed Central  Google Scholar 

  12. Bradbury KE, Murphy N, Key TJ (2019) Diet and colorectal cancer in UK Biobank: a prospective study. Int J Epidemiol. https://doi.org/10.1093/ije/dyz064

  13. Cascella M, Bimonte S, Barbieri A, Del Vecchio V, Caliendo D, Schiavone V et al (2018) Dissecting the mechanisms and molecules underlying the potential carcinogenicity of red and processed meat in colorectal cancer (CRC): an overview on the current state of knowledge. Infectious Agents Cancer 13(1):3

    PubMed  Google Scholar 

  14. Bastide NM, Pierre FH, Corpet DE (2011) Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved. Cancer Prev Res 4(2):177–184

    CAS  Google Scholar 

  15. Hamada T, Nowak JA, Masugi Y, Drew DA, Song M, Cao Y et al (2018) Smoking and risk of colorectal cancer sub-classified by tumor-infiltrating T cells. J Natl Cancer Inst 111(1):42–51

    PubMed Central  Google Scholar 

  16. Priemé H, Loft S, Klarlund M, Grønbæk K, Tønnesen P, Poulsen HE (1998) Effect of smoking cessation on oxidative DNA modification estimated by 8-oxo-7, 8-dihydro-2′-deoxyguanosine excretion. Carcinogenesis 19(2):347–351

    PubMed  Google Scholar 

  17. Tommasi S, Caliri AW, Caceres A, Moreno DE, Li M, Chen Y et al (2019) Deregulation of biologically significant genes and associated molecular pathways in the oral epithelium of electronic cigarette users. Int J Mol Sci 20(3):738

    PubMed Central  CAS  Google Scholar 

  18. Burgoa M, Regidor E, Rodríguez C, Gutiérrez-Fisac JL (1998) Mortality by cause of death and marital status in Spain. Eur J Public Health 8(1):37–42

    Google Scholar 

  19. Johansen C, Schou G, Soll-Johanning H, Mellemgaard A, Lynge E (1996) Influence of marital status on survival from colon and rectal cancer in Denmark. Br J Cancer 74(6):985

    PubMed  PubMed Central  CAS  Google Scholar 

  20. Kikuchi N, Nishiyama T, Sawada T, Wang C, Lin Y, Watanabe Y et al (2017) Perceived stress and colorectal cancer incidence: the Japan Collaborative Cohort Study. Sci Rep 7:40363

    PubMed  PubMed Central  CAS  Google Scholar 

  21. Yoshihara K, Hiramoto T, Sudo N, Kubo C (2011) Profile of mood states and stress-related biochemical indices in long-term yoga practitioners. BioPsychoSoc Med 5(1):6

    PubMed  PubMed Central  Google Scholar 

  22. Wei Y-C, Zhou F-L, He D-L, Bai J-R, Hui L-Y, Wang X-Y et al (2009) The level of oxidative stress and the expression of genes involved in DNA-damage signaling pathways in depressive patients with colorectal carcinoma. J Psychosom Res 66(3):259–266

    PubMed  Google Scholar 

  23. Rombouts A, Hugen N, van Beek J, Poortmans P, de Wilt J, Nagtegaal I (2018) Does pelvic radiation increase rectal cancer incidence?–A systematic review and meta-analysis. Cancer Treat Rev 68:136–144

    PubMed  CAS  Google Scholar 

  24. Boice JD Jr, Engholm G, Kleinerman RA, Blettner M, Stovall M, Lisco H et al (1988) Radiation dose and second cancer risk in patients treated for cancer of the cervix. Radiat Res 116(1):3–55

    PubMed  Google Scholar 

  25. Campbell PT, Cotterchio M, Dicks E, Parfrey P, Gallinger S, McLaughlin JR (2007) Excess body weight and colorectal cancer risk in Canada: associations in subgroups of clinically defined familial risk of cancer. Cancer Epidemiol Prev Biomarkers 16(9):1735–1744

    Google Scholar 

  26. Shaw E, Farris MS, Stone CR, Derksen JW, Johnson R, Hilsden RJ et al (2018) Effects of physical activity on colorectal cancer risk among family history and body mass index subgroups: a systematic review and meta-analysis. BMC Cancer 18(1):71

    PubMed  PubMed Central  Google Scholar 

  27. Meyerhardt JA, Heseltine D, Niedzwiecki D, Hollis D, Saltz LB, Mayer RJ et al (2006) Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol 24(22):3535–3541

    PubMed  Google Scholar 

  28. Martinez-Useros J, Garcia-Foncillas J (2016) Obesity and colorectal cancer: molecular features of adipose tissue. J Transl Med 14(1):21

    PubMed  PubMed Central  Google Scholar 

  29. Ma J, Pollak MN, Giovannucci E, Chan JM, Tao Y, Hennekens CH et al (1999) Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst 91(7):620–625

    PubMed  CAS  Google Scholar 

  30. Tsoi H, Chu ES, Zhang X, Sheng J, Nakatsu G, Ng SC et al (2017) Peptostreptococcus anaerobius induces intracellular cholesterol biosynthesis in colon cells to induce proliferation and causes dysplasia in mice. Gastroenterology 152(6):1419–33.e5

    PubMed  Google Scholar 

  31. Cao Y, Wu K, Mehta R, Drew DA, Song M, Lochhead P et al (2018) Long-term use of antibiotics and risk of colorectal adenoma. Gut 67(4):672–678

    PubMed  CAS  Google Scholar 

  32. Hattori N, Niwa T, Ishida T, Kobayashi K, Imai T, Mori A et al (2019) Antibiotics suppress colon tumorigenesis through inhibition of aberrant DNA methylation in an azoxymethane and dextran sulfate sodium colitis model. Cancer Sci 110(1):147

    PubMed  CAS  Google Scholar 

  33. Majumdar AP, Basson MD (2006) Effect of aging on the gastrointestinal tract. Physiol Gastrointest Tract 4:405–433

    Google Scholar 

  34. Han S, Gao J, Zhou Q, Liu S, Wen C, Yang X (2018) Role of intestinal flora in colorectal cancer from the metabolite perspective: a systematic review. Cancer Manag Res 10:199

    PubMed  PubMed Central  CAS  Google Scholar 

  35. Tremaroli V, Bäckhed F (2012) Functional interactions between the gut microbiota and host metabolism. Nature 489(7415):242

    PubMed  CAS  Google Scholar 

  36. Kosumi K, Mima K, Baba H, Ogino S (2018) Dysbiosis of the gut microbiota and colorectal cancer: the key target of molecular pathological epidemiology. J Lab Precis Med 3:76

    PubMed  PubMed Central  Google Scholar 

  37. Gagnière J, Raisch J, Veziant J, Barnich N, Bonnet R, Buc E et al (2016) Gut microbiota imbalance and colorectal cancer. World J Gastroenterol 22(2):501

    PubMed  PubMed Central  Google Scholar 

  38. Rubinstein MR, Wang X, Liu W, Hao Y, Cai G, Han YW (2013) Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin. Cell Host Microbe 14(2):195–206

    PubMed  PubMed Central  CAS  Google Scholar 

  39. Taieb F, Petit C, Nougayrède J-P, Oswald E (2016) The enterobacterial genotoxins: cytolethal distending toxin and colibactin. EcoSal Plus 7(1). https://doi.org/10.1128/ecosalplus.ESP-0008-2016

  40. Boleij A, Hechenbleikner EM, Goodwin AC, Badani R, Stein EM, Lazarev MG et al (2014) The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients. Clin Infect Dis 60(2):208–215

    PubMed  PubMed Central  Google Scholar 

  41. Boonanantanasarn K, Gill AL, Yap Y, Jayaprakash V, Sullivan MA, Gill SR (2012) Enterococcus faecalis enhances cell proliferation through hydrogen peroxide-mediated epidermal growth factor receptor activation. Infect Immun 80(10):3545–3558

    PubMed  PubMed Central  CAS  Google Scholar 

  42. Ohara T, Yoshino K, Kitajima M (2010) Possibility of preventing colorectal carcinogenesis with probiotics. Hepatogastroenterology 57(104):1411–1415

    PubMed  Google Scholar 

  43. Nagpal R, Kumar A, Kumar M, Behare PV, Jain S, Yadav H (2012) Probiotics, their health benefits and applications for developing healthier foods: a review. FEMS Microbiol Lett 334(1):1–15

    PubMed  CAS  Google Scholar 

  44. Wang Y, Wu Y, Wang Y, Xu H, Mei X, Yu D et al (2017) Antioxidant properties of probiotic bacteria. Nutrients 9(5):521

    PubMed Central  Google Scholar 

  45. Ilhan ZE, Marcus AK, Kang D-W, Rittmann BE, Krajmalnik-Brown R (2017) pH-mediated microbial and metabolic interactions in fecal enrichment cultures. Msphere 2(3):e00047–e00017

    PubMed  PubMed Central  CAS  Google Scholar 

  46. Shukla G, Verma A, Singh J, Yadav H (2014) Prebiotic inulin alters the colonic mass, pH, microflora and short chain fatty acids in 1,2-dimethylhydrazine dihydrochloride induced early colon carcinogenesis in male Laca mice. J Probiotics Health 2:1–6

    CAS  Google Scholar 

  47. Zhao Y, Yu Y-B (2016) Intestinal microbiota and chronic constipation. Springerplus 5(1):1130

    PubMed  PubMed Central  Google Scholar 

  48. Zhang X, Wu K, Cho E, Ma J, Chan AT, Gao X et al (2013) Prospective cohort studies of bowel movement frequency and laxative use and colorectal cancer incidence in US women and men. Cancer Causes Control 24(5):1015–1024

    PubMed  PubMed Central  Google Scholar 

  49. Raman M, Ambalam P, Kondepudi KK, Pithva S, Kothari C, Patel AT et al (2013) Potential of probiotics, prebiotics and synbiotics for management of colorectal cancer. Gut Microbes 4(3):181–192

    PubMed  PubMed Central  Google Scholar 

  50. Konishi H, Fujiya M, Tanaka H, Ueno N, Moriichi K, Sasajima J et al (2016) Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis. Nat Commun 7:12365

    PubMed  PubMed Central  CAS  Google Scholar 

  51. Ashraf R, Shah NP (2014) Immune system stimulation by probiotic microorganisms. Crit Rev Food Sci Nutr 54(7):938–956

    PubMed  CAS  Google Scholar 

  52. Sharma M, Shukla G (2016) Metabiotics: one step ahead of probiotics; an insight into mechanisms involved in anticancerous effect in colorectal cancer. Front Microbiol 7. https://doi.org/10.3389/fmicb.2016.01940

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Author information

Authors and Affiliations

  1. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

    Monica Gulati & Sachin Kumar Singh

  2. Department of Anaesthesiology and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Apoorva Singh

Authors
  1. Monica Gulati
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  2. Sachin Kumar Singh
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  3. Apoorva Singh
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Editors and Affiliations

  1. Department of Biochemistry, Central University of Haryana, Mahendergarh, Haryana, India

    Pawan K. Maurya

  2. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia

    Kamal Dua

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Gulati, M., Singh, S.K., Singh, A. (2020). The Role of Synbiotics in Alleviating Oxidative Stress in Colorectal Cancer. In: Maurya, P., Dua, K. (eds) Role of Oxidative Stress in Pathophysiology of Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-15-1568-2_6

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