Abstract
Differential scanning calorimetry (DSC) is a thermal analysis technique which involves the measurement of temperature difference between the sample and the reference material as a function of the temperature while sample and reference both are subjected to a controlled temperature program. This technique is especially used for qualitative and quantitative determination of change in temperature in terms of exothermic, endothermic, and heat capacity. In this chapter we have discussed the principle and types of DSC. The comprehensive instrumentation, working of the DSC, and the factors affecting the DSC curve have also been discussed in detail. The interpretation of the result through the curve is also elaborated. At the end of this chapter, advantages and disadvantages along with application have been described.
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Further Reading
Abraham J, Mohammed AP, Kumar AMP, George SC, Thomas S (2018) Chapter 8—thermoanalytical techniques of nanomaterials. In: Mohan Bhagyaraj S, Oluwafemi OS, Kalarikkal N, Thomas S (eds) Characterization of nanomaterials. Woodhead Publishing, Sawston, pp 213–236
Brown ME (2001) Introduction to thermal analysis: techniques and applications. Springer, Berlin
Brown ME, Gallagher PK (2011a) Handbook of thermal analysis and calorimetry: recent advances, techniques and applications. Elsevier, Amsterdam
Brown ME, Gallagher PK (2011b) Handbook of thermal analysis and calorimetry: recent advances, techniques and applications. Elsevier, Amsterdam
Charsley E, Price D, Hunter N, Gabbott P, Kett V, Gaisford S et al (2019) Principles of thermal analysis and calorimetry. Royal Society of Chemistry, London
Feist M (2015) Thermal analysis: basics, applications, and benefit. ChemTexts 1(1):8
Höhne G, Hemminger WF, Flammersheim H-J (2013) Differential scanning calorimetry. Springer, Berlin
Lopez MM, Makhatadze GI (2002) Differential scanning calorimetry. Calcium-binding protein protocols. In: Methods and techniques, vol 2. Springer, Berlin, pp 113–119
Menczel JD, Judovits L, Prime RB, Bair HE, Reading M, Swier S (2009) Chapter 2: differential scanning calorimetry (DSC). In: Menczel JD, Prime RB (eds) Thermal analysis of polymers: fundamentals and applications. Wiley, Hoboken, pp 7–239
Riga A, Collins R (2006) Differential scanning calorimetry and differential thermal analysis. In: Encyclopedia of analytical chemistry: applications, theory and instrumentation. Wiley, Hoboken
Schick C, Lexa D, Leibowitz L (2002) Differential scanning calorimetry and differential thermal analysis. In: Characterization of materials. Wiley, Hoboken, pp 1–13
Verdonck E, Schaap K, Thomas LC (1999) A discussion of the principles and applications of modulated temperature DSC (MTDSC). Int J Pharm 192(1):3–20
Wunderlich B, Analysis T (2001) In: Buschow KHJ, Cahn RW, Flemings MC, Ilschner B, Kramer EJ, Mahajan S et al (eds) Encyclopedia of materials: science and technology. Elsevier, Oxford, pp 9134–9141
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Akash, M.S.H., Rehman, K. (2020). Differential Scanning Calorimetry. In: Essentials of Pharmaceutical Analysis. Springer, Singapore. https://doi.org/10.1007/978-981-15-1547-7_17
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DOI: https://doi.org/10.1007/978-981-15-1547-7_17
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