Abstract
Natural products obtained from plants, animals and microorganisms are a gift of nature to humanity owing to their wide range of applications. Recent development in the fields of biotechnology has led to the revelation of novel functions of natural products in the textile industry, food industry, cosmetic industry and pharmaceutical industry. The scientific focus has been shifted to utilise sustainable and eco-friendly materials with the consumer’s increased awareness of eco-safety. With the advancement in technologies, the exploitation of rich natural sources has gained exploding interest commercially to isolate natural products. During recent years, the quest for novel drugs from potentially untapped natural resources has brought man closer to nature. Microorganisms represent a vast repertoire of natural products, many of them with medicinal importance. They are renowned potential mines enriched with novel natural products needed to tackle the grim situation of antibiotic resistance worldwide. Despite huge research underway, only a few microbial sources with unique natural products have been identified yet. Microbial sources have the potential to fuel the advanced generation of drugs by providing a platform to come up with a new golden age of microbe-derived therapeutics.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ahmed Y, Rebets Y, Tokovenko B, Brötz E, Luzhetskyy A (2017) Identification of butenolide regulatory system controlling secondary metabolism in Streptomyces albus J1074. Sci Rep 7:9784. https://doi.org/10.1038/s41598-017-10316-y
Al-Wahaibi Y, Joshi S, Al-Bahry S, Elshafie A, Al-Bemani A, Shibulal B (2014) Biosurfactant production by Bacillus subtilis B30 and its application in enhancing oil recovery. Colloids Surf B Biointerfaces 114:324–333
Asenjo J, Razmilic V, Castro JF, Gomez JP, Bull AT, Goodfellow M, Jaspars M, Bibb M, Andrews BA (2018) Microbial engineering of new Streptomyces sp. from extreme environments for novel antibiotics and anticancer drugs in “Microbial Engineering”, Prof. Eli Keshavarz-Moore, University College London, England Dr. Barry Buckland, BiologicB, USA Eds, ECI Symposium Series, http://dc.engconfintl.org/microbial/50
Atanasov AG, Waltenberger B, Pferschy-Wenzig E-M, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, Rollinger JM, Schuster D, Breuss JM, Bochkov V, Mihovilovic MD, Kopp B, Bauer R, Dirsch VM, Stuppner H (2015) Discovery and resupply of pharmacologically active plant–derived natural products: a review. Biotechnol Adv 33(8):1582–1614
Bäck J, Aaltonen H, Hellén H, Kajos MK, Patokoski J, Taipale R, Pumpanen J, Heinonsalo J (2010) Variable emissions of microbial volatile organic compounds (MVOCs) from root-associated fungi isolated from scots pine. Atmos Environ 44:3651–3659
Barba FJ, Zhu Z, Koubaa M, Sant’Ana AS, Orlien V (2016) Green alternative methods for the extraction of antioxidant bioactive compounds from winery wastes and by–products: a review. Trends Food Sci Technol 49:96–109
Barka EA, Vatsa P, Sanchez L, Gaveau-Vaillant N, Jacquard C, Klenk H-P, Clément C, Ouhdouch Y, van Wezel GP (2016) Taxonomy, physiology, and natural products of Actinobacteria. Microbiol Mol Biol Rev 80:1–43. https://doi.org/10.1128/MMBR.00019-15
Beller HR, Lee TS, Katz L (2015) Natural products as biofuels and bio-based chemicals: fatty acids and isoprenoids. Nat Prod Rep 32:1508–1526
Bernal MG, Campa-Córdova AI, Saucedo PE, Casanova-Gonzalez M, Medina-Marrero R, Mazón-Suástegui JM (2015) Isolation and in vitro selection of actinomycetes strains as potential probiotics for aquaculture. Veter World 8(2):170–176. https://doi.org/10.14202/vetworld.2015.170-176
Bezza FA, Evans M, Chirwa N (2015) Production and applications of lipopeptide biosurfactant for bioremediation and oil recovery by Bacillus subtilis CN2. Biochem Eng J 101:168–178
Bhati S, Kumar V, Singh S, Singh J (2019) Synthesis, biological activities and docking studies of piperazine incorporated 1, 3, 4-oxadiazole derivatives. J Mol Struct 1191:197–205
Bilyk O, Luzhetskyy A (2017) Host organisms: Streptomyces. In: Wittmann C, Liao JC (eds) Industrial biotechnology: microorganisms, vol 1. Wiley-VCH, Weinheim, pp 487–504
Biswas J, Paul AK (2014) Production of extracellular polymeric substances by halophilic bacteria of solar salterns. Chin J Biol. https://doi.org/10.1155/2014/205731
Brakhage AA, Schroeckh V (2011) Fungal secondary metabolites – strategies to activate silent gene clusters. Fungal Genet Biol 48(1):15–22
Cao XH, Wang AH, Wang CL, Mao DZ, Lu MF, Cui YQ, Jiao RZ (2010) Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNK-mediated mitochondrial/caspase pathway. Chem Biol Interact 183:357–362. https://doi.org/10.1016/j.cbi.2009.11.027
Chan JK, Brady MF, Penson RT, Huang H, Birrer MJ, Walker JL, DiSilvestro PA, Rubin SC, Martin LP, Davidson SA, Huh WK, O’Malley DM, Boente MP, Michael H, Mon BJ (2016) Weekly vs. every-3-week paclitaxel and carboplatin for ovarian cancer. N Engl J Med 374:738–748. https://doi.org/10.1056/NEJMoa1505067.
Chemat F, Rombaut N, Sicaire A–G, Meullemiestre A, Fabiano-Tixier A-S, Abert-Vian M (2017) Ultrasound assisted extraction of food and natural products. Mechanisms, techniques, combinations, protocols and applications. A review. Ultrason Sonochem 34:540–560
Chen Y, Nielsen J (2016) Biobased organic acids production by metabolically engineered microorganisms. Curr Opin Biotechnol 37:165–172
Chen WM, Tang YQ, Mori K, Wu XL (2012) Distribution of culturable endophytic bacteria in aquatic plants and their potential for bioremediation in polluted waters. Aquat Biol 15:99–110. https://doi.org/10.3354/ab00422
Chen J, Sun S, Li C-Z, Zhu Y-G, Rosen BP (2014) Biosensor for organoarsenical herbicides and growth promoters. Environ Sci Technol 48:1141–1147
Chen J, Li W, Yao H, Xu J (2015) Insights into drug discovery from natural products through structural modification. Fitoterapia 103:231–241. https://doi.org/10.1016/j.fitote.2015.04.012
Chubukov V, Mukhopadhyay A, Petzold CJ, Keasling JD, Martín HC (2016) Synthetic and systems biology for microbial production of commodity chemicals. NPJ Syst Biol Appl. https://doi.org/10.1038/npjsba.2016.9
Crits-Christoph A, Diamond S, Butterfield CN, Thomas BC, Banfield JF (2018) Novel soil bacteria possess diverse genes for secondary metabolite biosynthesis. Nature 558:440–444. https://doi.org/10.1038/s41586-018-0207-y
Dar RA, Majeed R, Sheikh AA, Rehman S, Hamid A, Hassan QP (2017) Emodin, isolated and characterized from an endophytic fungus Polyporales sp., induces apoptotic cell death in human lung cancer cells through the loss of mitochondrial membrane potential. J Phytopharma 6(5):288–292
Datta S, Singh J, Singh J, Singh S, Singh S (2018) Assessment of genotoxic effects of pesticide and vermicompost treated soil with Allium cepa test. Sustain Environ Res 28(4):171–178
Delekta PC, Raveh A, Larsen MJ, Schultz PJ, Tamayo-Castillo G, Sherman DH, Miller DJ (2014) The combined use of alphavirus replicons and pseudoinfectious particles for the discovery of antivirals derived from natural products. J Biomol Screen 20(5):673–680. https://doi.org/10.1177/1087057114564868
Diksha SA, Verma RK, Kaur G (2018) Study of antioxidant and phytochemical properties of compounds from Trigonella foenum-graceum and Trigonella corniculata. Int J Pharm Biol Sci 8(3):1039–1046
Dixit G, Samarth D, Tale V, Bhadekar R (2013) Comparative studies on potential probiotic characteristics of Lactobacillus acidophilus strains. Eurasia J Biosci 7:1–9
Dufossé L, Fouillaud M, Caro Y, Mapari SAS, Sutthiwong N (2014) Filamentous fungi are large-scale producers of pigments and colorants for the food industry. Curr Opin Biotechnol 26:56–61
Eyberger AL, Dondapati R, Porter JR (2006) Endophyte fungal isolates from Podophyllum peltatum produce podophyllotoxin. J Nat Prod 69:1121–1124
Grover M, Nain L, Singh SB, Saxena AK (2010) Molecular and biochemical approaches of characterization of antifungal trait of a potent bio control agent Bacillus subtilis RP24. Curr Microbiol 60:99–106
Hoffmann N, Pietruszka J, Soeffing C (2012) From sophorose lipids to natural product synthesis. Adv Synth Catal 354(6):959–963
Hu W, Deng C, Ma Z, Wang D, Fan C, Li T, Di S, Gong B, Reiter RJ, Yang Y (2017) Utilizing melatonin to combat bacterial infections and septic injury. Br J Pharmacol 174(9):754–768
Ismaiel AA, Ahmed AS, Hassan IA, El-Sayed ER, El-Din AAK (2017) Production of paclitaxel with anticancer activity by two local fungal endophytes, Aspergillus fumigatus and Alternaria tenuissima. Appl Microbiol Biotechnol 101(14):5831–5846. https://doi.org/10.1007/s00253-017-8354-x.
Jadhav VV, Yadav A, Yogesh SS, Sharma A, Alpna M, Sruthi P, Arora A, Kaustubh BR (2013) Studies on biosurfactant from Oceanobacillus sp. BRI 10 isolated from Antarctic Sea water. Desalination 318:64–71
Jahromi FM, Liang JB, Ho YW, Mohamad R, Goh YM, Shokryazdan P, Chin J (2013) Lovastatin in Aspergillus terreus: fermented rice straw extracts interferes with methane production and gene expression in Methanobrevibacter smithii. Biomed Res Int. https://doi.org/10.1155/2013/604721
John WA (2007) Teonanacatl: ancient and contemporary shamanic mushroom names of Mesoamerica and other regions of the world. John W Allen Psilly Publications and Raver Books, Washington
Kang JW (2014) Removing environmental organic pollutants with bioremediation and phytoremediation. Biotechnol Lett 6:1129–1139. https://doi.org/10.1007/s10529-014-1466-9.
Kapoor D, Singh S, Kumar V, Romero R, Prasad R, Singh J (2019) Antioxidant enzymes regulation in plants in reference to reactive oxygen species (ROS) and reactive nitrogen species (RNS). Plant Gene:100182
Karen MV, William M, Cedric JP, Nicholas HO (2011) Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma. J Antibiot (Tokyo) 64(8):525–531
Karlapudi AP, Venkateswarulu TC, Tammineedi J, Kanumuri L, Ravuru BK, ramu Dirisala V, Kodali VP (2018) Role of biosurfactants in bioremediation of oil pollution-a review. Petroleum 4(3):241–249
Katz L, Baltz RH (2016) Natural product discovery: past, present, and future. J Ind Microbiol Biotechnol 43:155–176. https://doi.org/10.1007/s10295-015-1723-5
Kaur P, Singh S, Kumar V, Singh N, Singh J (2018) Effect of rhizobacteria on arsenic uptake by macrophyte Eichhornia crassipes (Mart.) Solms. Int J Phytoremediation 20(2):114–120
Kim PI, Ryu J, Kim YH, Chi YT (2010) Production of biosurfactant lipopeptides iturin a, fengycin, and surfactin a from Bacillus subtilis CMB32 for control of Colletotrichum gloeosporioides. J Microbiol Biotechnol 20(1):138–145
Kulakovskaya T, Shashkov A, Kulakovskaya E, Golubev W, Zinin A, Tsvetkov Y, Grachev A, Nifantiev N (2009) Extracellular cellobiose lipid from yeast and their analogues: structures and fungicidal activities. J Oleo Sci 58(3):133–140
Kumar V, Singh S (2018a) Kinetics of dechlorination of atrazine using tin (SnII) at neutral pH conditions. Appl Chemical Engg 1(4)
Kumar V, Singh S (2018b) Interactions of Acephate, glyphosate, Monocrotophos and Phorate with bovine serum albumin. Indian J Pharm Sci 80(6):1151–1155
Kumar SV, Saravanan D, Kumar B, Jayakumar A (2014a) An update on prodrugs from natural products. Asian Pac J Trop Med 7(1):S54–S59
Kumar V, Upadhyay N, Kumar V, Kaur S, Singh J, Singh S, Datta S (2014b) Environmental exposure and health risks of the insecticide monocrotophos—a review. J biodivers. Environ Sci 5:111–120
Kumar V, Singh S, Singh J, Upadhyay N (2015) Potential of plant growth promoting traits by bacteria isolated from heavy metal contaminated soils. Bull Environ Contam Toxicol 94(6):807–814
Kumar V, Kaur S, Singh S, Upadhyay N (2016) Unexpected formation of N′-phenyl-thiophosphorohydrazidic acid O, S-dimethyl ester from acephate: chemical, biotechnical and computational study. 3 Biotech 6(1):1
Kumar S, Mulligan BP, Ojha S, Tinson A (2017a) Microbial source of melatonin and its clinical aspects. In: Kalia V (ed) Microbial applications, vol 2. Springer, Cham. https://doi.org/10.1007/978–3–319–52669–0_2
Kumar V, Singh S, Singh R, Upadhyay N, Singh J (2017b) Design, synthesis, and characterization of 2, 2-bis (2, 4-dinitrophenyl)-2-(phosphonatomethylamino) acetate as a herbicidal and biological active agent. J Chem Biol 10(4):179–190
Kumar V, Singh S, Singh A, Dixit AK, Srivastava B, Sidhu GK, Prakash O (2018a) Phytochemical, antioxidant, antimicrobial, and protein binding qualities of hydro-ethanolic extract of Tinospora cordifolia. J Biol Act Prod Nat 8(3):192–200
Kumar V, Singh S, Singh A, Dixit AK, Shrivastava B, Kondalkar SA, Subhose V (2018b) Determination of phytochemical, antioxidant, antimicrobial, and protein binding qualities of hydroethanolic extract of Celastrus paniculatus. J Appl Biol Biotechnol 6(06):11–17
Kumar V, Singh S, Singh R, Upadhyay N, Singh J, Pant P, Subhose V (2018c) Spectral, structural and energetic study of acephate, glyphosate, monocrotophos and phorate: an experimental and computational approach. J Taibah Univ Sci 12(1):69–78
Kumar V, Singh S, Srivastava B, Bhadouria R, Singh R (2019a) Green synthesis of silver nanoparticles using leaf extract of Holoptelea integrifolia and preliminary investigation of its antioxidant, anti-inflammatory, antidiabetic and antibacterial activities. J Environ Chem Engg:103094
Kumar V, Singh S, Singh R (2019b) Phytochemical constituents of guggul gum and their biological qualities. Mini Rev Org Chem 16. https://doi.org/10.2174/1570193X16666190129161757
Kumar V, Singh S, Singh A, Subhose V, Prakash O (2019c) Assessment of heavy metal ions, essential metal ions, and antioxidant properties of the most common herbal drugs in Indian Ayurvedic hospital: for ensuring quality assurance of certain Ayurvedic drugs. Biocatal Agric Biotechnol 18:101018
Kusari S, Lamshöft M, Spiteller M (2009) Aspergillus fumigatus Fresenius, an endophytic fungus from Juniperus communis L. Horstmann as a novel source of the anticancer pro‐drug deoxypodophyllotoxin. J Appl Microbiol 107(3):1019–1030
Landman D, Georgescu C, Martin DA, Quale J (2008) Polymyxins revisited. Clin Microbiol 21(3):449–465. https://doi.org/10.1128/CMR.00006-08
Laorrattanasak S, Rongsayamanont W, Khondee N, Paorach N, Soonglerdsongpha S, Pinyakong O, Luepromchai OE (2016) Production and application of Gordonia westfalica GY40 biosurfactant for remediation of fuel oil spill. Water Air Soil Pollut 227:325. https://doi.org/10.1007/s11270-016-3031-8
Lee C, Park S, Ayush I, Cho K, Kim SS, Kang I, Choe W, Kim Y-S, Yoon K-S (2018) Effects of Myxococcus fulvus KYC4048 metabolites on breast cancer cell death. J Microbiol Biotechnol 28(5):765–775
Li H–Y, Wei D–Q, Shen M, Zhou Z–P (2012) Endophytes and their role in phytoremediation. Fungal Divers 54:11–18. https://doi.org/10.1016/j.tibtech.2012.04.004
Li L, Jiang W, Lu Y (2017) New strategies and approaches for engineering biosynthetic gene clusters of microbial natural products. Biotechnol Adv 35(8):936–949
Liu C, Gallagher JJ, Sakimoto KK, Nichols EM, Chang CJ, Chang MCY, Yang P (2015) Nanowire–bacteria hybrids for unassisted solar carbon dioxide fixation to value-added chemicals. Nano Lett 15(5):3634–3639
Mackeyev Y, Raoof M, Cisneros B, Koshkina N, Berger CS, Wilson LJ, Curley SA (2014) Toward paclitaxel-[60] fullerene immunoconjugates as a targeted prodrug against cancer. Nanosyst Phys Chem Math 5(1):67–75
Mishra V, Gupta A, Kaur P, Singh S, Singh N, Gehlot P, Singh J (2016) Synergistic effects of Arbuscular mycorrhizal fungi and plant growth promoting rhizobacteria in bioremediation of iron contaminated soils. Int J Phytoremediation 18(7):697–703
Nair MS, Amalaradjou MA, Venkitanarayanan K (2017) Antivirulence properties of probiotics in combating microbial pathogenesis. Adv Appl Microbiol 98:1–29. https://doi.org/10.1016/bs.aambs.2016.12.001
Nisa H, Kamili AN, Nawchoo IA, Shafi S, Shameem N, Bandh SA (2015) Fungal endophytes as prolific source of phytochemicals and other bioactive natural products: a review. Microb Pathog 82:50–59
Oja T, Galindo PSM, Taguchi T, Manner S, Vuorela PM, Ichinose K, Metsä-Ketelä M, Fallarero A (2015) Effective anti–biofilm polyketides against Staphylococcus aureus from the pyranonaphthoquinone biosynthetic pathways of Streptomyces species. Antimicrob Agents Chemother 59:6046–6052. https://doi.org/10.1128/AAC.00991–15
de Oliveira NC, Rodrigues AA, Alves MIR, Filho NRA, Sadoyama G, Vieira JDG (2012) Endophytic bacteria with potential for bioremediation of petroleum hydrocarbons and derivatives. Afr J Biotechnol 11:2977–2984. https://doi.org/10.5897/AJB10.2623
Pacwa-Płociniczak M, Płaza GA, Piotrowska-Seget Z, Cameotra SS (2011) Environmental applications of biosurfactants: recent advances. Int J Mol Sci 12(1):633–654
Pandey A, Chandra N, Srivastava A, Kumar D, Kumar S (2018) Antimicrobial metabolites producing soil microorganisms: an update. Indian J Appl Microbiol 21(1):46–57
Paulose JK, Wright JM, Patel AG, Cassone VM (2016) Human gut bacteria are sensitive to melatonin and express endogenous circadian rhythmicity. PLoS One. https://doi.org/10.1371/journal.pone.0146643
Paytubi S, de La Cruz M, Tormo JR, Martín J, González I, González-Menendez V, Genilloud O, Reyes F, Vicente F, Madrid C, Balsalobre C (2017) A high–throughput screening platform of microbial natural products for the discovery of molecules with antibiofilm properties against Salmonella. Front Microbiol 8:326. https://doi.org/10.3389/fmicb.2017.00326
Pote S, Bhadekar R (2014) Statistical approach for production of PUFA from Kocuria sp. BRI 35 isolated from marine water sample. Biomed Res Int:570925. https://doi.org/10.1155/2014/570925
Praveen VK, Bhargavi SD, Savitha J (2015) Lovastatin production by Aspergillus terreus (KM017963) in submerged and solid state fermentation: a comparative study. Am J Pharm Health Res 3(7):116–126
Puri SC, Nazir A, Chawla R, Arora R, Riyaz-ul-Hasan S, Amna T, Ahmed B, Verma V, Singh S, Sagar R, Sharma A, Kumar R, Sharma RK, Qazi GN (2006) The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllotoxin and related aryl tetralin lignans. J Biotechnol 122:494–510
Raja PB, Sethuraman MG (2008) Natural products as corrosion inhibitor for metals in corrosive media—a review. Mater Lett 62(1):113–111
Rani BEA, Basu BBJ (2011) Green inhibitors for corrosion protection of metals and alloys: an overview. Int J Corros 2017:15. https://doi.org/10.1155/2012/380217
Rodrigues T, Reker D, Schneider P, Schneider G (2016) Counting on natural products for drug design. Nat Chem 8:531–541
Rutledge PJ, Challis GL (2015) Discovery of microbial natural products by activation of silent biosynthetic gene clusters. Nat Rev Microbiol 13:509–523
Saini HS, Barragán-Huerta BE, Lebrón-Paler A, Pemberton JE, Vázquez RR, Burns AM, Marron MT, Seliga CJ, Gunatilaka AA, Maier RM (2008) Efficient purification of the biosurfactant viscosin from Pseudomonas libanensis strain M9-3 and its physicochemical and biological properties. J Nat Prod 71:1011–1015
Sanders ME, Merenstein DJ, Ouwehand AC, Reid G, Salminen S, Cabana MD, Paraskevakos G, Leyer G (2016) Probiotic use in at-risk populations. J Am Pharm Assoc 56(6):680–686
Schep LJ, Knudsen K, Slaughter RJ, Vale JA, Mégarbane B (2012) The clinical toxicology of γ–hydroxybutyrate, γ–butyrolactone and 1,4–butanediol. Clin Toxicol (Phila) 50(6):458–470
Selvin J, Ninawe AS, Kiran GS, Arya S, Priyadharshini S (2016) Bioactive marine natural products insights into marine microbes, seaweeds, and marine sponges as potential sources of drug discovery. In: Leo MLN (ed) Marine microorganisms extraction and analysis of bioactive compounds. Taylor & Francis, Boca Raton, pp 3–13
Shankar T, Vijayabaskar P, Sivasankara N, Sivakumar T (2014) Screening of exopolysaccharide producing bacterium Frateuria aurentia from elephant dung. Appl Sci Rep 5(3):105–109
Sharma A, Verma RK (2018) Root-microbe interactions: understanding and exploitation of microbiome. In: Giri B, Prasad R, Verma A (eds) Root biology., Soil Biology 52, part of Springer. Springer International Publishing AG, pp 323–339. https://doi.org/10.1007/978-3-319-75910-4_13
Sidhu GK, Singh S, Kumar V, Dhanjal DS, Datta S, Singh J (2019) Toxicity, monitoring and biodegradation of organophosphate pesticides: a review. Crit Rev Environ Sci Technol 49:1–53
da Silva BV, Barreira JCM, Oliveira MBPP (2016) Natural phytochemicals and probiotics as bioactive ingredients for functional foods: extraction, biochemistry and protected-delivery technologies. Trends Food Sci Technol 50:144–158
Singh S, Singh N, Kumar V, Datta S, Wani AB, Singh D, Singh J (2016) Toxicity, monitoring and biodegradation of the fungicide carbendazim. Environ Chem Lett 14(3):317–329
Singh S, Kumar V, Upadhyay N, Singh J, Singla S, Datta S (2017) Efficient biodegradation of acephate by pseudomonas pseudoalcaligenes PS-5 in the presence and absence of heavy metal ions [cu (II) and Fe (III)], and humic acid. 3 Biotech 7(4):262
Singh S, Kumar V, Chauhan A, Datta S, Wani AB, Singh N, Singh J (2018) Toxicity, degradation and analysis of the herbicide atrazine. Environ Chem Lett 16(1):211–237
Singh S, Kumar V, Singh J (2019a) Kinetic study of the biodegradation of glyphosate by indigenous soil bacterial isolates in presence of humic acid, Fe (III) and cu (II) ions. J Environ Chemical Engg:103098
Singh S, Kumar V, Sidhu GK, Datta S, Dhanjal DS, Koul B, Singh J (2019b) Plant growth promoting rhizobacteria from heavy metal contaminated soil promote growth attributes of Pisum sativum L. Biocatal Agric Biotechnol 17:665–671
Singh S, Kumar V, Singh S, Singh J (2019c) Influence of humic acid, iron and copper on microbial degradation of fungicide Carbendazim. Biocatal Agric Biotechnol:101196. https://doi.org/10.1016/j.bcab.2019.101196
Slomovic S, Pardee K, Collins JJ (2015) Synthetic biology devices for in vitro and in vivo diagnostics. Proc Natl Acad Sci U S A 112:14429–14435
Soliev AB, Hosokawa K, Enomoto K (2011) Bioactive pigments from marine bacteria: applications and physiological roles. Evid Based Complement Alternat Med:17. https://doi.org/10.1155/2011/670349
Stępniewska Z, Kuźniar A (2013) Endophytic microorganisms—promising applications in bioremediation of greenhouse gases. Appl Microbiol Biotechnol 97(22):9589–9596. https://doi.org/10.1007/s00253-013-5235-9
Tuli HS, Chaudhary P, Beniwal V, Sharma AK (2015) Microbial pigments as natural color sources: current trends and future perspectives. J Food Sci Technol 52(8):4669–4678. https://doi.org/10.1007/s13197-014-1601-6
Wang CL, Liu C, Niu LL, Wang LR, Hou LH, Cao XH (2013) Surfactin-induced apoptosis through ROS-ERS-Ca2+-ERK pathways in HepG2 cells. Cell Biochem Biophys 67:1433–1439. https://doi.org/10.1007/s12013-013-9676-7
Wang J, Guleria S, Koffas MAG, Yan Y (2016) Microbial production of value-added nutraceuticals. Curr Opin Biotechnol 37:97–104
Wani AB, Chadar H, Wani AH, Singh S, Upadhyay N (2017) Salicylic acid to decrease plant stress. Environ Chem Lett 15(1):101–123
Wenzel SC, Müller R (2009) Myxobacteria—‘microbial factories’ for the production of bioactive secondary metabolites. Mol BioSyst 5(6):567
Yang Y, Zhao H, Barrero RA, Zhang B, Sun G, Wilson IW, Xie F, Walker KD, Parks JW, Bruce R, Guo G, Chen L, Zhang Y, Huang X, Tang Q, Liu H, Bellgard MI, Qiu D, Lai J, Hoffman A (2014) Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431. BMC Genomics 15(69). https://doi.org/10.1186/1471-2164-15-69
Yuan H, Ma Q, Li Y, Piao G (2016) The traditional medicine and modern medicine from natural products. Molecules 21:559. https://doi.org/10.3390/molecules21050559
Zhou X, Liu J, Yang B, Lin X, Yang X-W, Liu Y (2013) Marine natural products with anti-HIV activities in the last decade. Curr Med Chem 20:953–973
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Verma, R.K., Sharma, A. (2020). Microbial Natural Products: Recent Insights into Novel Applications. In: Singh, J., Meshram, V., Gupta, M. (eds) Bioactive Natural products in Drug Discovery. Springer, Singapore. https://doi.org/10.1007/978-981-15-1394-7_9
Download citation
DOI: https://doi.org/10.1007/978-981-15-1394-7_9
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-1393-0
Online ISBN: 978-981-15-1394-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)