Skip to main content

Community- and Hospital-Acquired Acute Kidney Injury

  • Chapter
  • First Online:
Acute Kidney Injury and Regenerative Medicine

Abstract

Community-acquired acute kidney injury (CA-AKI) has been found to be more common than hospital-acquired acute kidney injury (HA-AKI), even though the incidence is underestimated. Data comparing these two phenotypes of AKI are limited using various definitions. CA-AKI appears to be more common in male and younger patients. Preexisting chronic kidney disease is the most important risk factor for both CA- and HA-AKI. Difficulty in recognition of AKI in the community may lead to higher severity of CA-AKI compared to HA-AKI. Unlike HA-AKI, the causes of CA-AKI vary by geography, environment, socioeconomic status of patients, and level of hospital care. Interestingly, there are some unique spectrums of CA-AKI in the tropic areas. Despite the difference in epidemiologic profile between CA- and HA-AKI, the long-term outcomes are similar.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Hou SH, Bushinsky DA, Wish JB, Cohen JJ, Harrington JT. Hospital-acquired renal insufficiency: a prospective study. Am J Med. 1983;74(2):243–8.

    Article  CAS  PubMed  Google Scholar 

  2. Shusterman N, Strom BL, Murray TG, Morrison G, West SL, Maislin G. Risk factors and outcome of hospital-acquired acute renal failure. Clinical epidemiologic study. Am J Med. 1987;83(1):65–71.

    Article  CAS  PubMed  Google Scholar 

  3. Brivet FG, Kleinknecht DJ, Loirat P, Landais PJ. Acute renal failure in intensive care units—causes, outcome, and prognostic factors of hospital mortality; a prospective, multicenter study. French Study Group on Acute Renal Failure. Crit Care Med. 1996;24(2):192–8.

    Article  CAS  PubMed  Google Scholar 

  4. Feest TG, Round A, Hamad S. Incidence of severe acute renal failure in adults: results of a community based study. BMJ. 1993;306(6876):481–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Liano F, Pascual J. Epidemiology of acute renal failure: a prospective, multicenter, community-based study. Madrid Acute Renal Failure Study Group. Kidney Int. 1996;50(3):811–8.

    Article  CAS  PubMed  Google Scholar 

  6. Kaufman J, Dhakal M, Patel B, Hamburger R. Community-acquired acute renal failure. Am J Kidney Dis. 1991;17(2):191–8.

    Article  CAS  PubMed  Google Scholar 

  7. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, Acute Dialysis Quality Initiative W. Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute dialysis Quality Initiative (ADQI) Group. Crit Care. 2004;8(4):R204–12.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Kidney disease: improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012;2:1–138.

    Google Scholar 

  9. Wonnacott A, Meran S, Amphlett B, Talabani B, Phillips A. Epidemiology and outcomes in community-acquired versus hospital-acquired AKI. Clin J Am Soc Nephrol. 2014;9(6):1007–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Evans RD, Hemmila U, Craik A, Mtekateka M, Hamilton F, Kawale Z, et al. Incidence, aetiology and outcome of community-acquired acute kidney injury in medical admissions in Malawi. BMC Nephrol. 2017;18(1):21.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Warnock DG, Powell TC, Siew ED, Donnelly JP, Wang HE, Mehta RL. Serum creatinine trajectories for community-versus hospital-acquired acute kidney injury. Nephron. 2016;134(3):177–82.

    Article  CAS  PubMed  Google Scholar 

  12. Wang Y, Wang J, Su T, Qu Z, Zhao M, Yang L, et al. Community-acquired acute kidney injury: a nationwide survey in China. Am J Kidney Dis. 2017;69(5):647–57.

    Article  PubMed  Google Scholar 

  13. Susantitaphong P, Cruz DN, Cerda J, Abulfaraj M, Alqahtani F, Koulouridis I, et al. World incidence of AKI: a meta-analysis. Clin J Am Soc Nephrol. 2013;8(9):1482–93.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Obialo CI, Okonofua EC, Tayade AS, Riley LJ. Epidemiology of de novo acute renal failure in hospitalized African Americans: comparing community-acquired vs hospital-acquired disease. Arch Intern Med. 2000;160(9):1309–13.

    Article  CAS  PubMed  Google Scholar 

  15. Schissler MM, Zaidi S, Kumar H, Deo D, Brier ME, McLeish KR. Characteristics and outcomes in community-acquired versus hospital-acquired acute kidney injury. Nephrology (Carlton). 2013;18(3):183–7.

    Article  Google Scholar 

  16. Der Mesropian PJ, Kalamaras JS, Eisele G, Phelps KR, Asif A, Mathew RO. Long-term outcomes of community-acquired versus hospital-acquired acute kidney injury: a retrospective analysis. Clin Nephrol. 2014;81(3):174–84.

    Article  Google Scholar 

  17. Yang L. Acute kidney injury in Asia. Kidney Dis (Basel). 2016;2(3):95–102.

    Article  Google Scholar 

  18. Yang L, Xing G, Wang L, Wu Y, Li S, Xu G, et al. Acute kidney injury in China: a cross-sectional survey. Lancet. 2015;386(10002):1465–71.

    Article  PubMed  Google Scholar 

  19. Xu X, Nie S, Liu Z, Chen C, Xu G, Zha Y, et al. Epidemiology and clinical correlates of AKI in Chinese hospitalized adults. Clin J Am Soc Nephrol. 2015;10(9):1510–8.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Bouchard J, Mehta RL. Acute kidney injury in Western countries. Kidney Dis (Basel). 2016;2(3):103–10.

    Article  Google Scholar 

  21. Olowu WA, Niang A, Osafo C, Ashuntantang G, Arogundade FA, Porter J, et al. Outcomes of acute kidney injury in children and adults in sub-Saharan Africa: a systematic review. Lancet Glob Health. 2016;4(4):e242–50.

    Article  PubMed  Google Scholar 

  22. Inokuchi R, Hara Y, Yasuda H, Itami N, Terada Y, Doi K. Differences in characteristics and outcomes between community- and hospital-acquired acute kidney injury: a systematic review and meta-analysis. Clin Nephrol. 2017;88(10):167–82.

    Article  PubMed  Google Scholar 

  23. Talabani B, Zouwail S, Pyart RD, Meran S, Riley SG, Phillips AO. Epidemiology and outcome of community-acquired acute kidney injury. Nephrology (Carlton). 2014;19(5):282–7.

    Article  Google Scholar 

  24. Wang Y, Cui Z, Fan M. Hospital-acquired and community-acquired acute renal failure in hospitalized Chinese: a ten-year review. Ren Fail. 2007;29(2):163–8.

    Article  CAS  PubMed  Google Scholar 

  25. Prakash J, Singh TB, Ghosh B, Malhotra V, Rathore SS, Vohra R, et al. Changing epidemiology of community-acquired acute kidney injury in developing countries: analysis of 2405 cases in 26 years from eastern India. Clin Kidney J. 2013;6(2):150–5.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Stucker F, Ponte B, De la Fuente V, Alves C, Rutschmann O, Carballo S, et al. Risk factors for community-acquired acute kidney injury in patients with and without chronic kidney injury and impact of its initial management on prognosis: a prospective observational study. BMC Nephrol. 2017;18(1):380.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  27. Barton AL, Mallard AS, Parry RG. One year’s observational study of acute kidney injury incidence in primary care; frequency of follow-up serum creatinine and mortality risk. Nephron. 2015;130(3):175–81.

    Article  PubMed  Google Scholar 

  28. Hobbs H, Bassett P, Wheeler T, Bedford M, Irving J, Stevens PE, et al. Do acute elevations of serum creatinine in primary care engender an increased mortality risk? BMC Nephrol. 2014;15:206.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  29. Sawhney S, Fluck N, Fraser SD, Marks A, Prescott GJ, Roderick PJ, et al. KDIGO-based acute kidney injury criteria operate differently in hospitals and the community-findings from a large population cohort. Nephrol Dial Transplant. 2016;31(6):922–9.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Akram AR, Singanayagam A, Choudhury G, Mandal P, Chalmers JD, Hill AT. Incidence and prognostic implications of acute kidney injury on admission in patients with community-acquired pneumonia. Chest. 2010;138(4):825–32.

    Article  CAS  PubMed  Google Scholar 

  31. Mehta RL, Cerda J, Burdmann EA, Tonelli M, Garcia-Garcia G, Jha V, et al. International society of nephrology’s 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology. Lancet. 2015;385(9987):2616–43.

    Article  PubMed  Google Scholar 

  32. Jha V, Parameswaran S. Community-acquired acute kidney injury in tropical countries. Nat Rev Nephrol. 2013;9(5):278–90.

    Article  CAS  PubMed  Google Scholar 

  33. Rennie TJW, De Souza N, Donnan PT, Marwick CA, Davey P, Dreischulte T, et al. Risk of acute kidney injury following community prescription of antibiotics: self-controlled case series. Nephrol Dial Transplant. 2019;34(11):1910–6.

    Article  PubMed  Google Scholar 

  34. Griffin MR, Yared A, Ray WA. Nonsteroidal antiinflammatory drugs and acute renal failure in elderly persons. Am J Epidemiol. 2000;151(5):488–96.

    Article  CAS  PubMed  Google Scholar 

  35. Huerta C, Castellsague J, Varas-Lorenzo C, Garcia Rodriguez LA. Nonsteroidal anti-inflammatory drugs and risk of ARF in the general population. Am J Kidney Dis. 2005;45(3):531–9.

    Article  CAS  PubMed  Google Scholar 

  36. Lapi F, Azoulay L, Yin H, Nessim SJ, Suissa S. Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study. BMJ. 2013;346:e8525.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  37. Dreischulte T, Morales DR, Bell S, Guthrie B. Combined use of nonsteroidal anti-inflammatory drugs with diuretics and/or renin-angiotensin system inhibitors in the community increases the risk of acute kidney injury. Kidney Int. 2015;88(2):396–403.

    Article  CAS  PubMed  Google Scholar 

  38. Chou CI, Shih CJ, Chen YT, Ou SM, Yang CY, Kuo SC, et al. Adverse effects of oral nonselective and cyclooxygenase-2-selective NSAIDs on hospitalization for acute kidney injury: a nested case-control cohort study. Medicine (Baltimore). 2016;95(9):e2645.

    Article  CAS  Google Scholar 

  39. Zhang X, Donnan PT, Bell S, Guthrie B. Non-steroidal anti-inflammatory drug induced acute kidney injury in the community dwelling general population and people with chronic kidney disease: systematic review and meta-analysis. BMC Nephrol. 2017;18(1):256.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  40. Sever MS, Lameire N, Van Biesen W, Vanholder R. Disaster nephrology: a new concept for an old problem. Clin Kidney J. 2015;8(3):300–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Gibney RT, Sever MS, Vanholder RC. Disaster nephrology: crush injury and beyond. Kidney Int. 2014;85(5):1049–57.

    Article  PubMed  Google Scholar 

  42. Gurrieri C, Garovic VD, Gullo A, Bojanic K, Sprung J, Narr BJ, et al. Kidney injury during pregnancy: associated comorbid conditions and outcomes. Arch Gynecol Obstet. 2012;286(3):567–73.

    Article  PubMed  Google Scholar 

  43. Prakash J, Gupta A, Kumar O, Rout SB, Malhotra V, Srivastava PK. Acute renal failure in falciparum malaria—increasing prevalence in some areas of India—a need for awareness. Nephrol Dial Transplant. 1996;11(12):2414–6.

    Article  CAS  PubMed  Google Scholar 

  44. Sitprija V. Renal dysfunction in leptospirosis: a view from the tropics. Nat Clin Pract Nephrol. 2006;2(12):658–9.

    Article  PubMed  Google Scholar 

  45. Teles F, de Mendonca Uchoa JV, Mirelli Barreto Mendonca D, Falcao Pedrosa Costa A. Acute kidney injury in leptospirosis: the Kidney Disease Improving Global Outcomes (KDIGO) criteria and mortality. Clin Nephrol. 2016;86 (2016)(12):303–9.

    Google Scholar 

  46. Karsanji DJ, Pannu N, Manns BJ, Hemmelgarn BR, Tan Z, Jindal K, et al. Disparity between nephrologists’ opinions and contemporary practices for community follow-up after AKI hospitalization. Clin J Am Soc Nephrol. 2017;12(11):1753–61.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Hsu CN, Lee CT, Su CH, Wang YC, Chen HL, Chuang JH, et al. Incidence, outcomes, and risk factors of community-acquired and hospital-acquired acute kidney injury: a retrospective cohort study. Medicine (Baltimore). 2016;95(19):e3674.

    Article  Google Scholar 

  48. Sesso R, Roque A, Vicioso B, Stella S. Prognosis of ARF in hospitalized elderly patients. Am J Kidney Dis. 2004;44(3):410–9.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Peerapornratana, S., Srisawat, N. (2020). Community- and Hospital-Acquired Acute Kidney Injury. In: Terada, Y., Wada, T., Doi, K. (eds) Acute Kidney Injury and Regenerative Medicine . Springer, Singapore. https://doi.org/10.1007/978-981-15-1108-0_10

Download citation

  • DOI: https://doi.org/10.1007/978-981-15-1108-0_10

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-1107-3

  • Online ISBN: 978-981-15-1108-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics