Abstract
A 70-year-old man presented with right mandibular pain and history of right mandibular third molar extraction 20 months back. Examination revealed purulence, exposed bone, and mental nerve hypoesthesia. He was previously prescribed zoledronate to treat bone metastases from pulmonary adenocarcinoma. PET/CT images taken 5 months before the first visit demonstrated increased mandibular FDG uptake. The inflammation remained symptomatic despite zoledronate discontinuation and antibiotic administration, with left mandibular bone exposure. SPECT/CT images demonstrated increased MDP uptake and bilateral mandibular bone destruction. Mandibular resection and pathological investigation revealed a sequestrum, indicating chronic osteomyelitis, leading to diagnosis of ARONJ (stages III and I).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Assaf T, et al. Intraindividual comparison of preoperative 99mTc-MDP SPECT/CT and intraoperative and histopathological findings in patients with bisphosphonate- or denosumab-related osteonecrosis of the jaw. J Craniomaxillofac Surg. 2015;43(8):1461–9.
Fleisher KE, et al. Does fluorodeoxyglucose positron emission tomography with computed tomography facilitate treatment of medication-related osteonecrosis of the jaw? J Oral Maxillofac Surg. 2016;74(5):945–58.
Heye T, Stoijkovic M, Kauczor HU, Junghanss T, Hosch W. Extrapulmonary tuberculosis: radiological imaging of an almost forgotten transformation artist. Rofo. 2011;183(11):1019–29.
Ankrah AO, Glaudemans AWJM, et al. Tuberculosis. Seminars in nuclear medicine. Semin Nucl Med. 2018;48:108–30.
Martinez V, Castilla-Lievre MA, Guillet-Caruba C, et al. (18)F-FDG PET/CT in tuberculosis: an early non-invasive marker of therapeutic response. Int J Tuberc Lung Dis. 2012;16(9):1180–5.
Vorster M, Sathekge MM, Bomanji J. Advances in imaging of tuberculosis: the role of 18F-FDG PET and PET/CT. Curr Opin Pulm Med. 2014;20(3):287–93.
Ito K, et al. Imaging spectrum and pitfalls of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in patients with tuberculosis. Jpn J Radiol. 2013;31(8):511–20.
Testempassi E, et al. Constrictive tuberculous pericarditis diagnosed using 18F-fluorodeoxyglucose positron emission tomography: a report of two cases. Ann Nucl Med. 2010;24(5):421–5.
Global Tuberculosis Report World Health Organization, Geneva; 2018.
Zumla A, et al. Tuberculosis. N Engl J Med. 2013;368:745–55.
Douglas AP, Thursky KA, Worth LJ, Drummond E, Hogg A, Hicks RJ, Slavin MA. FDG PET/CT imaging in detecting and guiding management of invasive fungal infections: a retrospective comparison to conventional CT imaging. Eur J Nucl Med Mol Imaging. 2019;46(1):166–73.
Seban RD, Bonardel G, Guernou M, Lussato D, Queneau M. The use of FDG PET-CT imaging for the assessment of early antifungal treatment response in disseminated fusariosis. Clin Nucl Med. 2017;42(7):569–70.
Ankrah AO, Klein HC, Span LFR, de Vries EFJ, Dierckx RAJO, Sathekge MM, Glaudemans AWJM. The role of PET in monitoring therapy in fungal infections. Curr Pharm Des. 2018;24(7):795–805.
Leroy-Freschini B, Treglia G, Argemi X, Bund C, Kessler R, Herbrecht R, Imperiale A. 18F-FDG PET/CT for invasive fungal infection in immunocompromised patients. QJM. 2018;111(9):613–22.
Hohmann C, Michels G, Schmidt M, et al. Diagnostic challenges in infective endocarditis: is PET/CT the solution? Infection. 2019;47(4):579–87.
Chen W, Dilsizian V. FDG PET/CT for the diagnosis and management of infective endocarditis: expert consensus vs evidence-based practice. J Nucl Cardiol. 2019;26(1):313–5.
Mahmood M, Kendi AT, Ajmal S, et al. Meta-analysis of 18F-FDG PET/CT in the diagnosis of infective endocarditis. J Nucl Cardiol. 2019;26(3):922–35.
Pizzi MN, Roque A, Fernández-Hidalgo N, et al. Improving the diagnosis of infective endocarditis in prosthetic valves and intracardiac devices with 18F-fluordeoxyglucose positron emission tomography/computed tomography angiography. Circulation. 2015;132(12):1113–26.
Kouijzer IJE, Berrevoets MAH, Aarntzen EHJG, et al. 18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis. Nucl Med Commun. 2018;39(8):747–52.
Smids C, Kouijzer IJ, Vos FJA, et al. Comparison of the diagnostic value of MRI and 18F-FDG-PET/CT in suspected spondylodiscitis. Infection. 2017;45(1):41–9.
Ioannou S, Chatziioannou S, Pneumaticos SG, Zormpala A, Sipsas NV. Fluorine-18 fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography scan contributes to the diagnosis and management of brucellar spondylodiskitis. BMC Infect Dis. 2013;13:73.
Zhang T, Wang C, Niu R, Wang X. Pulmonary brucellosis on FDG PET/CT. Clin Nucl Med. 2014;39(2):222–3.
Alduraibi AK, Naddaf S, Alzayed MF. FDG PET/CT of spinal brucellosis. Clin Nucl Med. 2019;44(6):465–6.
Wang HH, Lin WR. Amebic liver abscess. N Engl J Med. 2018;379(23):2255.
Cavailloles FA, Mure A, Nasser H, et al. Multiple liver amoebic abscesses detected on FDG PET/CT. Clin Nucl Med. 2014;39:79–80.
Zhou W, Zhao J, Xing Y, et al. Diffuse hepatic amebiasis detected by FDG PET/CT. Clin Nucl Med. 2015;40:e167–70.
Yapar AF, Reyhan M, Canpolat ET. Interesting image. Ameboma mimicking lung cancer on FDG PET/CT. Clin Nucl Med. 2010;35:55–6.
Dong A, Wang Y, Zuo C, Zhu HFDGPET. CT findings in multiple splenic amebomas (amebic granulomas). Clin Nucl Med. 2016;41(5):379–81.
Scharko A, et al. Whole-body positron emission tomography in patients with HIV-1 infection. Lancet. 2003;20:959–61.
Sathekge M, et al. FDG-PET imaging in HIV infection and tuberculosis. Semin Nucl Med. 2013;43:349–66.
Scharko AM, et al. Whole-body positron emission tomography imaging of simian immunodeficiency virus-infected rhesus macaques. Proc Natl Acad Sci U S A. 1996;93(13):6425–30.
Lucignani G, et al. FDG-PET imaging in HIV-infected subjects: relation with therapy and immunovirological variables. Eur J Nucl Med Mol Imaging. 2009;36:640–7.
Lew DP, et al. Osteomyelitis. Lancet. 2004;364(9431):369–79.
van der Bruggen W, et al. PET and SPECT in osteromyelitis and prosthetic bone and joint infections: a systematic review. Semin Nucl Med. 2010;40(1):3–15.
Lemans JVC, et al. The diagnostic accuracy of 18F-FDG PET/CT in diagnosing fracture-related infections. Eur J Nucl Med Mol Imaging. 2018;46:999–1008. https://doi.org/10.1007/s00259-018-4218-6.
Sallée M, et al. Cyst infections in patients with autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol. 2009;4:1183–9.
Lantiga MA, et al. Diagnostic criteria in renal and hepatic cyst infection. Nephrol Dial Transplant. 2015;30:744–51.
Bleeker-Rovers CP, et al. Diagnosis of renal and hepatic cyst infections by 18-F-fluorodeoxyglucose positron emission tomography in autosomal dominant polycystic kidney disease. Am J Kidney Dis. 2003;41:E18–21.
Pijl JP, et al. FDG-PET/CT in autosomal dominant polycystic kidney disease patients with suspected cyst infection. J Nucl Med. 2018;59:1734–41.
Umeoka S, et al. High 18F-fluorodeoxyglocose uptake in adrenal histoplasmosis: a case report. Eur Radiol. 2005;15(12):2483–6.
Narang V, et al. Clinically inapparent bilateral adrenal masses due to histoplasmosis. Eur Urol. 2009;55(2):518–21.
Tsai YJ, et al. 18F-fluorodeoxyglucose positron emission tomography for the initial evaluation and monitoring of therapeutic response in bilateral adrenal histoplasmosis. Clin Imaging. 2013;37(4):791–3.
Shah SA, et al. [18F]Fluorodeoxyglucose-avid adrenal masses due to histoplasmosis. J Clin Oncol. 2009;27(5):827–8.
Kalathoorakath RR, et al. (18)F-FDG PET/CT imaging and PET-guided biopsy in evaluation and treatment decision in adrenal histoplasmosis. BJR Case Rep. 2016;2(3):20150451.
Suggested Readings
Igbinedion S, Mavuram MS, Boktor M, Bienvenu J. Pyogenic liver abscess caused by methicillin-susceptible Staphylococcus aureus in a 21-year-old male. Case Reports Hepatol. 2018; https://doi.org/10.1155/2018/9868701. E Collection 2018
Jolobe OMP. The special case of the left lobe amoebic liver abscess. QJM. 2019;112(1):67–8.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Toyama, H. et al. (2020). FDG-PET/CT for a Variety of Infectious Diseases. In: Toyama, H., Li, Y., Hatazawa, J., Huang, G., Kubota, K. (eds) PET/CT for Inflammatory Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-15-0810-3_3
Download citation
DOI: https://doi.org/10.1007/978-981-15-0810-3_3
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-0809-7
Online ISBN: 978-981-15-0810-3
eBook Packages: MedicineMedicine (R0)