Abstract
Conventionally, autophagy (=self-eating) is thought to be a catabolic cellular process that is responsible for regulating cell homeostasis. However, the newly evidence have expanded the range of the impact of autophagy in biology. Autophagy interplays with endocytosis through shared factors such as phosphatidylinositol 3 kinase complex (PI(3)K complex), autophagy associated gene (Atg), and lysosome. Autophagy and phagocytosis orchestrate in maintaining homeostasis, in MHC class II antigen processing, in the removal of pathogens, in cell death, immunity, and inflammation. There are numerous cross talks of autophagy with biosynthetic processes such as conventional and unconventional secretion of biologically active cargo and trafficking of integral membrane proteins, as well as the exosome secretion. There are also links between autophagy and trafficking events from plasma membrane, including lateral plasma membrane proteins connexins, cell connections, and ciliogenesis.
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References
Axe EL, Walker SA, Manifava M, Chandra P, Roderick HL, Habermann A, Griffiths G, Ktistakis NT (2008) Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 182:685–701
Baixauli F, Lopez-Otin C, Mittelbrunn M (2014) Exosomes and autophagy: coordinated mechanisms for the maintenance of cellular fitness. Front Immunol 5:403
Bruns C, McCaffery JM, Curwin AJ, Duran JM, Malhotra V (2011) Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion. J Cell Biol 195:979–992
Deretic V, Jiang SY, Dupont N (2012) Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation. Trends Cell Biol 22:397–406
Farhan H, Kundu M, Ferro-Novick S (2017) The link between autophagy and secretion: a story of multitasking proteins. Mol Biol Cell 28:1161–1164
Gee HY, Noh SH, Tang BL, Kim KH, Lee MG (2011) Rescue of DeltaF508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway. Cell 146:746–760
Kaksonen M, Roux A (2018) Mechanisms of clathrin-mediated endocytosis. Nat Rev Mol Cell Biol 19:313–326
Keller CW, Loi M, Ligeon LA, Gannage M, Lunemann JD, Munz C (2018) Endocytosis regulation by autophagy proteins in MHC restricted antigen presentation. Curr Opin Immunol 52:68–73
Lamb CA, Dooley HC, Tooze SA (2013) Endocytosis and autophagy: shared machinery for degradation. BioEssays 35:34–45
Loi M, Muller A, Steinbach K, Niven J, da Silva RB, Paul P, Ligeon LA, Caruso A, Albrecht RA, Becker AC, Annaheim N, Nowag H, Dengjel J, Garcia-Sastre A, Merkler D, Munz C, Gannage M (2016) Macroautophagy proteins control MHC class I levels on dendritic cells and shape anti-viral CD8(+) T cell responses. Cell Rep 15:1076–1087
Manjithaya R, Anjard C, Loomis WF, Subramani S (2010) Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation. J Cell Biol 188:537–546
Martinez J, Almendinger J, Oberst A, Ness R, Dillon CP, Fitzgerald P, Hengartner MO, Green DR (2011) Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. Proc Natl Acad Sci USA 108:17396–17401
Matsunaga K, Morita E, Saitoh T, Akira S, Ktistakis NT, Izumi T, Noda T, Yoshimori T (2010) Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J Cell Biol 190:511–521
Munz C (2017) Autophagy proteins in phagocyte endocytosis and exocytosis. Front Immunol 8
Nagata S, Hanayama R, Kawane K (2010) Autoimmunity and the clearance of dead cells. Cell 140:619–630
Narita M, Young ARJ, Arakawa S, Samarajiwa SA, Nakashima T, Yoshida S, Hong SK, Berry LS, Reichelt S, Ferreira M, Tavare S, Inoki K, Shimizu S, Narita M (2011) Spatial coupling of mTOR and autophagy augments secretory phenotypes. Science 332:966–970
Oczypok EA, Oury TD, Chu CT (2013) It’s a cell-eat-cell world: autophagy and phagocytosis. Am J Pathol 182:612–622
Pavel M, Rubinsztein DC (2017) Mammalian autophagy and the plasma membrane. FEBS J 284:672–679
Qu X, Zou Z, Sun Q, Luby-Phelps K, Cheng P, Hogan RN, Gilpin C, Levine B (2007) Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell 128:931–946
Romao S, Gasser N, Becker AC, Guhl B, Bajagic M, Vanoaica D, Ziegler U, Roesler J, Dengjel J, Reichenbach J, Munz C (2013) Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing. J Cell Biol 203:757–766
Sanjuan MA, Dillon CP, Tait SW, Moshiach S, Dorsey F, Connell S, Komatsu M, Tanaka K, Cleveland JL, Withoff S, Green DR (2007) Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature 450:1253–1257
Stuart LM, Ezekowitz RA (2008) Phagocytosis and comparative innate immunity: learning on the fly. Nat Rev Immunol 8:131–141
Vernon PJ, Tang DL (2013) Eat-me: autophagy, phagocytosis, and reactive oxygen species signaling. Antioxid Redox Signal 18:677–690
Viotti C (2016) ER to Golgi-dependent protein secretion: the conventional pathway. Methods Mol Biol 1459:3–29
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Zhang, HL., Zhu, YM., Zhou, XY. (2019). Coordination of Autophagy and Other Cellular Activities. In: Qin, ZH. (eds) Autophagy: Biology and Diseases. Advances in Experimental Medicine and Biology, vol 1206. Springer, Singapore. https://doi.org/10.1007/978-981-15-0602-4_30
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DOI: https://doi.org/10.1007/978-981-15-0602-4_30
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