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Neurodevelopment and Neurobehavioral Disorders in Relation to Developmental Exposures

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Health Impacts of Developmental Exposure to Environmental Chemicals

Abstract

The environment is now known to be an important determinant of child health, with increasing evidence that some chemicals are particularly toxic to the human brain. More than 140,000 new chemicals have been synthesized since 1950. In this chapter, we review the most studied neurotoxicants for their associations with neurodevelopment and the potential mechanisms of action. We describe the societal effects of such contaminants, and discuss the main challenges facing studies investigating potential neurodevelopmental effects of chemicals. Finally, we provide future directions for the next generation of developmental neuroepidemiology studies.

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Authors and Affiliations

  1. Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA

    Youssef Oulhote

  2. Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA

    Youssef Oulhote & David C. Bellinger

  3. Department of Neurology, Harvard Medical School, Boston, MA, USA

    David C. Bellinger

  4. Boston Children’s Hospital, Boston, MA, USA

    David C. Bellinger

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  1. Youssef Oulhote
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Correspondence to Youssef Oulhote .

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  1. Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan

    Reiko Kishi

  2. Department of Environmental Health Harvard T.H. Chan School of Public Health, Boston, MA, USA

    Philippe Grandjean

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Oulhote, Y., Bellinger, D.C. (2020). Neurodevelopment and Neurobehavioral Disorders in Relation to Developmental Exposures. In: Kishi, R., Grandjean, P. (eds) Health Impacts of Developmental Exposure to Environmental Chemicals. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-15-0520-1_7

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