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Ischemic Postconditioning

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Cardioprotection Against Acute Myocardial Infarction
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Abstract

Ischemic postconditioning refers to a episodes of brief ischemia and reperfusion applied after reperfusion. In contrast to the ischemic preconditioning which is conducted before the onset of ischemia, postconditioning is performed after reperfusion. This protection is characterized as a reduction of infarct size and an improvement of postischemic cardiac dysfunction.

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References

  1. Zhao ZQ, Corvera JS, Halkos ME, Kerendi F, Wang NP, Guyton RA, Vinten-Johansen J. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol 2003; 285: H579-H588.

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  2. Tsang A, Hausenloy DJ, Mocanu MM, Yellon DM. Postconditioning: a form of “modified reperfusion” protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway. Circ Res 2004; 95: 230–2.

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Minatoguchi, S. (2019). Ischemic Postconditioning. In: Cardioprotection Against Acute Myocardial Infarction. Springer, Singapore. https://doi.org/10.1007/978-981-15-0167-8_4

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