Abstract
The formation of atherosclerosis mainly depends on local hemodynamic blood flow parameters. The spatial and temporal variation of hemodynamic blood flow parameter is considered as an important factor for atherogenesis. The laminar, Newtonian pulsatile blood flow is considered for hemodynamic analysis of the idealized non-stenosis human coronary artery. To model and study the relationship between relative residence time (RRT), time-averaged wall shear stress (WSS) vector (TAWSSV), oscillatory shear index (OSI), and time-averaged WSS (TAWSS) the computational fluid dynamics technique are used. The study shows that higher OSI values are predicted at lower TAWSS and TAWSSV. At the low TAWSS areas the RRT attains a higher value, the region with high RRT correlates with atherosclerotic lesions on the artery wall. The local differences between RRT, OSI, and WSS magnitude may help to find predominantly where the atherosclerotic lesion progresses and develops at specific locations of the artery.
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References
Huang, J., Lyczkowski, R.W., Gidaspow, D.: Pulsatile flow in a coronary artery using multiphase kinetic theory. J. Biomech. 42(6), 743–754 (2009)
World Health Organization: The world health report 2002: reducing risks, promoting healthy life. World Health Organization (2002)
Caro, C.G., Fitz-Gerald, J.M., Schroter, R.C.: Arterial wall shear and distribution of early atheroma in man. Nature 223(5211), 1159–1161 (1969)
Caro, C.G., Fitz-Gerald, J.M., Schroter, R.C.: Atheroma: a new hypothesis. BMJ 2(5762), 651 (1971)
Davies, P.F.: Flow-mediated endothelial mechanotransduction. Physiol. Rev. 75(3), 519–560 (1995)
Gimbrone Jr., M.A., García-Cardeña, G.: Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis. Cardiovasc Pathol 22(1), 9–15 (2013)
Ethier, C.R.: Computational modeling of mass transfer and links to atherosclerosis. Ann. Biomed. Eng. 30(4), 461–471 (2002)
Malek, A.M., Alper, S.L., Izumo, S.: Hemodynamic shear stress and its role in atherosclerosis. JAMA 282(21), 2035–2042 (1999)
Ross, R.: Atherosclerosis—an inflammatory disease. N. Engl. J. Med. 340(2), 115–126 (1999)
Soulis, J.V., Fytanidis, D.K., Papaioannou, V.C., Giannoglou, G.D.: Wall shear stress on LDL accumulation in human RCAs. Med. Eng. Phys. 32(8), 867–877 (2010)
Himburg, H.A., Grzybowski, D.M., Hazel, A.L., LaMack, J.A., Li, X.M., Friedman, M.H.: Spatial comparison between wall shear stress measures and porcine arterial endothelial permeability. Am. J. Physiol. Heart Circ. Physiol. 286(5), H1916–H1922 (2004)
Xue, Y., Liu, X., Sun, A., Zhang, P., Fan, Y., Deng, X.: Hemodynamic performance of a new punched stent strut: a numerical study. Artif. Organs. 40(7), 669–677 (2016)
Do, H., Owida, A.A., Yang, W., Morsi, Y.S.: Numerical simulation of the haemodynamics in end-to-side anastomoses. Int. J. Numer. Meth. Fluids 67(5), 638–650 (2011)
Berne, R.M., Levy, M.N.: Cardiovascular Physiology. Mosby (1967)
Fluent, A.N.S.Y.S.: 14.5, theory guide. Ansys. Inc., Canonsburg (2012)
Johnston, B.M., Johnston, P.R., Corney, S., Kilpatrick, D.: Non-Newtonian blood flow in human right coronary arteries: steady state simulations. J. Biomech. 37(5), 709–720 (2004)
Anderson, J.D., Wendt, J.: Computational fluid dynamics, vol. 206. McGraw-Hill, New York (1995)
Buchanan Jr., J.R., Kleinstreuer, C., Truskey, G.A., Lei, M.: Relation between non-uniform hemodynamics and sites of altered permeability and lesion growth at the rabbit aorto-celiac junction. Atherosclerosis 143(1), 27–40 (1999)
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Buradi, A., Mahalingam, A. (2020). Numerical Analysis of Wall Shear Stress Parameters of Newtonian Pulsatile Blood Flow Through Coronary Artery and Correlation to Atherosclerosis. In: Biswal, B., Sarkar, B., Mahanta, P. (eds) Advances in Mechanical Engineering. Lecture Notes in Mechanical Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-15-0124-1_12
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DOI: https://doi.org/10.1007/978-981-15-0124-1_12
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