Abstract
Fractionation is a very important aspect of delivering radiation to the tumor to attain maximum tumor control and with minimal toxicity to the normal tissues. Conventional fractionation refers to delivering radiation at daily fractions of 1.8–2.0 Gy, delivered 5 days of a week for a total of 6–7 weeks. Hyper-fractionation, accelerated fractionation, and hypo-fractionation are the common altered fractionation schedules used clinically. The chapter describes the radiobiology, benefits, and clinical evidence for various altered fractionation schedules.
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References
Mallick S, Benson R, Julka PK, Rath GK. Altered fractionation radiotherapy in head and neck squamous cell carcinoma. J Egypt Natl Canc Inst. 2016;28(2):73–80.
Pignon JP, le Maître A, Maillard E, Bourhis J, et al. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol. 2009;92(1):4–14.
Haviland JS, Owen JR, Dewar JA, Agrawal RK, Barrett J, Barrett-Lee PJ, et al. The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials. Lancet Oncol. 2013;14(11):1086–94.
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Mallick, S., Rath, G.K. (2020). Altered Fractionation Radiotherapy. In: Mallick, S., Rath, G., Benson, R. (eds) Practical Radiation Oncology. Springer, Singapore. https://doi.org/10.1007/978-981-15-0073-2_30
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DOI: https://doi.org/10.1007/978-981-15-0073-2_30
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