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Brain Iron Metabolism and CNS Diseases pp 105–123Cite as

Iron Pathophysiology in Stroke

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 1173)

Abstract

Ischemic and hemorrhagic stroke are the common types of stroke that lead to brain injury neurological deficits and mortality. All forms of stroke remain a serious health issue, and there is little successful development of drugs for treating stroke. Incomplete understanding of stroke pathophysiology is considered the main barrier that limits this research progress. Besides mitochondria and free radical-producing enzymes, labile iron is an important contributor to oxidative stress. Although iron regulation and metabolism in cerebral stroke are not fully understood, much progress has been achieved in recent years. For example, hepcidin has recently been recognized as the principal regulator of systemic iron homeostasis and a bridge between inflammation and iron regulation. This review discusses recent research progress in iron pathophysiology following cerebral stroke, focusing molecular regulation of iron metabolism and potential treatment targets.

Keywords

  • Stroke
  • Iron
  • Hepcidin
  • FPN1
  • HIF-1α
  • Anesthesia

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Fig. 6.1
Fig. 6.2
Fig. 6.3

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Acknowledgements

This investigation was supported by the University of Kansas General Research Fund. Mohammed M. A. Almutairi was supported by a scholarship from King Saud University (Riyadh, Saudi Arabia).

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS, 66045, USA

    Mohammed M. A. Almutairi & Honglian Shi

  2. Department of Pharmacology and Toxicology, School of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    Mohammed M. A. Almutairi

  3. Department of Anesthesiology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA

    Grace Xu

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  1. Mohammed M. A. Almutairi
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  3. Honglian Shi
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Correspondence to Honglian Shi .

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  1. College of Life Sciences, Hebei Normal University , Shijiazhuang, Hebei, China

    Yan-Zhong Chang

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Almutairi, M.M.A., Xu, G., Shi, H. (2019). Iron Pathophysiology in Stroke. In: Chang, YZ. (eds) Brain Iron Metabolism and CNS Diseases. Advances in Experimental Medicine and Biology, vol 1173. Springer, Singapore. https://doi.org/10.1007/978-981-13-9589-5_6

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