Inhibition of Excessive Keratinocyte Growth in Psoriasis using Drugs Cyclosporin and FK506

Abstract

Till now, we have discussed the dynamics of Psoriasis with the help of three particular cells, viz., T-Cells (CD4$^{+}$ T-Cells), Dendritic Cells, and Keratinocytes. But CD8$^{+}$ T-Cells has a crucial role toward the disease Psoriasis. To measure the effect of CD8$^{+}$ T-Cell population on Psoriatic system, we have introduced CD8$^{+}$ T-Cell population in the mathematical model of Psoriasis that interacts with DCs in the system. This interaction leads to generate Keratinocytes, which in turn supports to expand the Keratinocytes growth. To confine this growth, we have applied drug at the interaction between CD8$^{+}$ T-Cells and DCs. Another method to produce Keratinocytes is the interaction between T-Cells and Keratinocytes itself. We have also set the drug in that interaction to control the growth of Keratinocytes, whose surplus production generates the disease Psoriasis.