Basic Mathematical Model on Immunopathogenic Plaque of Psoriasis

Abstract

Psoriasis is a common chronic inflammatory human skin disorder characterized by T-Cell-mediated hyperproliferation of epidermal Keratinocytes. Cell-biological findings on the disease reveal that Helper T-Cells in the human blood as well as Dendritic Cells (DCs) play a significant role in inflicting the disease. Further, clinical research suggests that excessive generation of nitric oxide through a complex chain of biochemical events causes scaliness of Psoriatic plaques on human skin. On that basis, in this chapter, we have tried to formulate the basic mathematical model involving the densities of immune cells and Keratinocytes, where proliferation of Keratinocytes together with excessive nitric oxide production is a precursor to the Psoriatic lesions.