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Pharmacokinetics and Pharmacodynamics of Polyphenols

Abstract

Polyphenols possess numerous biological effects but have low oral bioavailability since they are extensively metabolized by phase 1 (CYP P450 family) and phase 2 (UDP-glucuronosyltransferases, sulfotransferases) enzymes in the enterocytes, liver, and also by gut microbiota. In addition they also have poor aqueous solubility. Bioavailability and pharmacodynamic action of the polyphenol and its metabolites are dependent on the interaction between the transporter proteins, metabolic enzymes, gut microbiota, host factors, source, and properties of the polyphenol.

Keywords

  • Bioavailability
  • Gut microbiota
  • Transporter proteins
  • Phase 1 metabolism
  • Phase 2 metabolism
  • Pharmacokinetic parameters

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Hoda, M., Hemaiswarya, S., Doble, M. (2019). Pharmacokinetics and Pharmacodynamics of Polyphenols. In: Role of Phenolic Phytochemicals in Diabetes Management. Springer, Singapore. https://doi.org/10.1007/978-981-13-8997-9_7

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