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Synergistic Behavior of Phytophenolics with Antidiabetic Drugs

  • Muddasarul Hoda
  • Shanmugam Hemaiswarya
  • Mukesh Doble
Chapter

Abstract

Diabetes is a highly complex disease with multiple metabolic changes. So a single disease management strategy is ineffective in controlling it and its related risk factors. Common conventional hypoglycemic drugs cause side effects and toxicities. Combination therapy is the best strategy to address multitargeting of the complex metabolic disease and to reduce the dose of the drug and hence the related toxicity/side effect. With the growth of herbal market, there are several reports on herb and drug interactions through pharmacokinetic and pharmacodynamic modes which can be either synergistic or antagonistic in nature. This chapter elaborates on the interaction of herb or a phytochemical with the oral diabetic drugs where the combination differs pharmacokinetically or pharmacodynamically than that of the individual compounds. There is an urgent need in the clinical studies and management of herb and drug combinations to understand both the beneficial and harmful interactions.

Keywords

Combination therapy Herb–drug interactions Pharmacodynamics Synergy Antagonism Additive 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Muddasarul Hoda
    • 1
    • 2
  • Shanmugam Hemaiswarya
    • 1
  • Mukesh Doble
    • 1
  1. 1.Department of BiotechnologyIndian Institute of Technology MadrasChennaiIndia
  2. 2.Department of Biological SciencesAliah UniversityKolkataIndia

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