Extracellular Vesicles: Opportunities and Challenges for the Treatment of Renal Fibrosis
Extracellular vesicles (EVs) are small lipid-based membrane-bound vesicles secreted by most cells under both physiological and pathological conditions. A key function of EVs is to mediate cell–cell communication via transferring mRNAs, miRNAs and proteins from parent cells to recipient cells. These unique features of EVs have spurred a renewed interest in their utility for therapeutics. Given the growing evidence for EV-mediated renal diseases, strategies that could block the release or uptake of pathogenic EVs will be discussed in this review. Then, the therapeutic potential of EVs predominantly from stem cells in renal diseases will be outlined. Finally, we will focus on the specific application of EVs as a novel drug delivery system and highlight the challenges of EVs-based therapies for renal diseases.
KeywordsExtracellular vesicles Treatment Renal fibrosis Drug delivery
This chapter was modified from a paper reported by our group in Front Physiol (Tang et al. 2019).
This study was supported by grants from the National Key Research and Development Program of China (2018YFC1314004), the National Natural Science Foundation of China (No.81720108007, 81670696, 81470922 and 31671194), the Clinical Research Center of Jiangsu Province (No. BL2014080) and the Postgraduate Research and Practice Innovation Program of Jiangsu Province (No. KYCX18_0171).
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