Abstract
Currently, type 2 diabetes is one of the most widespread noncommunicable maladies that inflict more than 400 million people globally. Diabetes-induced oxidative stress and distortion in gastrointestinal microbiota seem to play an important role in the occurrence of metabolic syndrome and related disorders. Oxidative stress causes imbalance between highly reactive oxygen species (ROS) and antioxidant systems of the body, resulting in metabolic syndrome, atherosclerosis, cardiovascular diseases, kidney problem, neuropathy, retinopathy, cancer risk, etc. Some studies show that imbalance in the gut microbiota also contributes in the development of type 2 diabetes. Microbial dysbiosis is considered to cause diabetic complications like cardiometabolic syndrome. Soluble dietary fibers have beneficial effects on gut microbiota and promote metabolic benefits on glucose control, but the underlying mechanisms remain unknown. Oral administration of purified and standardized phytopharmaceuticals containing bioactive compounds of different medicinal plants which help to normalize blood sugar level and promote healthy microbiota have proven useful in the prevention, mitigation, and management of diabetes as well as associated cardiometabolic syndrome. Recently, probiotics/prebiotics/synbiotics have gained importance in promoting healthy microbiota in diabetic patients. Probiotics consist of live bacteria present in foods like yogurt/cheese that confer health benefits on the host, while prebiotics are indigestible oligosaccharides that promote growth of beneficial bacteria in the gut. The focus of the review is to highlight the therapeutic potential of various types of phytomedicines and their known mechanistic actions involved in the management of type 2 diabetes. Results of clinical trials of herbal remedies and probiotics/prebiotics in humans and in vivo effects observed in animal models will also be described in this review. Randomized, placebo-controlled, and double-blind clinical studies with robust endpoints are needed for establishing the long-term safety, efficacy, and therapeutic relevance of phytopharmaceuticals and probiotics/ prebiotics/synbiotics in treating patients suffering from type 2 diabetes.
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References
Diabetes Prevention Program Research Group (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346(6):393–403
Daisy P, Saipriya K (2012) Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus. Int J Nanomedicine 7:1189
Piconi L, Quagliaro L, Ceriello A (2003) Oxidative stress in diabetes. Clin Chem Lab Med 41(9):1144–1149
Wright E, Scism-Bacon JL, Glass LC (2006) Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia. Int J Clin Pract 60(3):308–314
Betteridge DJ (2000) What is oxidative stress? Metabolism 49(2 Suppl 1):3–8
Morteza A, Jenab Y, Nargesi AA, Ghazizadeh Z, Salabati M (2012) Urea and oxidative stress in type 2 diabetes. J Metabolic Synd 1(105):2167–0943
Crommen S, Simon MC (2017) Microbial regulation of glucose metabolism and insulin resistance. Genes 9(1):10
Vrieze A, Van Nood E, Holleman F, Salojärvi J, Kootte RS, Bartelsman JF et al (2012) Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 143(4):913–916
Qin J, Li Y, Cai Z., Li S, Zhu J, Zhang F, … Peng Y (2012) A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490(7418):55–last page
Karlsson FH, Tremaroli V, Nookaew I, Bergström G, Behre CJ, Fagerberg B et al (2013) Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 498(7452):99
Wu H, Esteve E, Tremaroli V, Khan MT, Caesar R, Mannerås-Holm L et al (2017) Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. Nat Med 23(7):850
Tilg H, Kaser A (2011) Gut microbiome, obesity, and metabolic dysfunction. J Clin Invest 121(6):2126–2132
Tremaroli V, Bäckhed F (2012) Functional interactions between the gut microbiota and host metabolism. Nature 489(7415):242
Diamant M, Blaak EE, De Vos WM (2011) Do nutrient–gut–microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes? Obes Rev 12(4):272–281
Everard A, Cani PD (2013) Diabetes, obesity and gut microbiota. Best Pract Res Clin Gastroenterol 27(1):73–83
Devaraj S, Hemarajata P, Versalovic J (2013) The human gut microbiome and body metabolism: implications for obesity and diabetes. Clin Chem 59(4):617–628
Kootte RS, Vrieze A, Holleman F, Dallinga-Thie GM, Zoetendal EG, de Vos WM et al (2012) The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus. Diabetes Obes Metab 14(2):112–120
Mingqian H, Shi B (2017) Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics. Cell Biosci 7(1):54
Delzenne NM, Cani PD (2011) Gut microbiota and the pathogenesis of insulin resistance. Curr Diab Rep 11(3):154
Makiura N, Ojima M, Kou Y, Furuta N, Okahashi N, Shizukuishi S, Amano A (2008) Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment. Mol Oral Microbiol 23(4):348–351
Aemaimanan P, Amimanan P, Taweechaisupapong S (2013) Quantification of key periodontal pathogens in insulin-dependent type 2 diabetic and non-diabetic patients with generalized chronic periodontitis. Anaerobe 22:64–68
Thorstensson H, Dahlen G, Hugoson A (1995) Some suspected periodontopathogens and serum antibody response in adult long-duration insulin-dependent diabetics. J Clin Periodontol 22(6):449–458
Kazi S (2014) Use of traditional plants in diabetes mellitus. Intl J Pharmaceut 4(4):283–289
Bathaie SZ, Mokarizade N, Shirali S (2012) An overview of the mechanisms of plant ingredients in the treatment of diabetes mellitus. J Med Plants 4(44):1–24
Hui H, Zhao X, Perfetti R (2005) Structure and function studies of glucagon-like peptide-1 (GLP-1): the designing of a novel pharmacological agent for the treatment of diabetes. Diabetes Metab Res Rev 21(4):313–331
Kooti W, Moradi MT, Ali-Akbari S, Sharafi-Ahvazi N, Asadi-Samani M, Ashtary-Larky D (2014) Therapeutic and pharmacological potential of Foeniculum vulgare Mill: a review. J Herb Med Pharmacol:4
Afrisham R, Aberomand M, Ghaffari MA, Siahpoosh A, Jamalan M (2015) Inhibitory effect of Heracleum persicum and Ziziphus jujuba on activity of alpha-amylase. J Bot 2015:1
Sies H, Cadenas E (1985) Oxidative stress: damage to intact cells and organs. Phil Trans R Soc Lond B 311(1152):617–631
Johansen JS, Harris AK, Rychly DJ, Ergul A (2005) Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovasc Diabetol 4(1):5
Bansal AK, Bilaspuri GS (2011) Impacts of oxidative stress and antioxidants on semen functions. Vet Med Intl 2011:1–7
Pham-Huy LA, He H, Pham-Huy C (2008) Free radicals, antioxidants in disease and health. Intl J Biomed Sci IJBS 4(2):89
Lipinski B (2001) Pathophysiology of oxidative stress in diabetes mellitus. J Diabetes Complicat 15(4):203–210
Maritim AC, Sanders A, Watkins J (2003) Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 17(1):24–38
Moussa SA (2008) Oxidative stress in diabetes mellitus. Romanian J Biophys 18(3):225–236
Erejuwa OO (2012) Oxidative stress in diabetes mellitus: is there a role for hypoglycemic drugs and/or antioxidants. Oxidative Stress Diseases 217:246
Larsen N, Vogensen FK, van den Berg FW, Nielsen DS, Andreasen AS, Pedersen BK et al (2010) Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One 5(2):e9085
Zhang X, Shen D, Fang Z, Jie Z, Qiu X, Zhang C, Ji L (2013) Human gut microbiota changes reveal the progression of glucose intolerance. PLoS One 8(8):e71108
Ceolotto G, Bevilacqua M, Papparella I, Baritono E, Franco L, Corvaja C, Avogaro A (2004) Insulin generates free radicals by an NAD (P) H, phosphatidylinositol 3′-kinase-dependent mechanism in human skin fibroblasts ex vivo. Diabetes 53(5):1344–1351
Levy J, Gavin JR, Sowers JR (1994) Diabetes mellitus: a disease of abnormal cellular calcium metabolism? Am J Med 96(3):260–273
Wohaieb SA, Godin DV (1987) Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat: effects of insulin treatment. Diabetes 36(9):1014–1018
Sardesai VM (1995) Role of antioxidants in health maintenance. Nutr Clin Pract 10(1):19–25
Gibaldi M (1996) Antioxidant vitamins and health. J Clin Pharmacol 36(12):1093–1099
Gökkus C, Palanduz S, Ademoğlu E, Tamer S (2001) Oxidant and antioxidant systems in NIDDM patients: influence of vitamin E supplementation. Endocr Res 27(3):377–386
Garcia-Medina JJ, Pinazo-Duran MD, Garcia-Medina M, Zanon-Moreno V, Pons-Vazquez SA (2011) A 5-year follow-up of antioxidant supplementation in type 2 diabetic retinopathy. Eur J Ophthalmol 21(5):637–643
Perez C, Canal JR, Torres MD (2003) Experimental diabetes treated with ficus carica extract: effect on oxidative stress parameters. Acta Diabetol 40(1):3–8
Welihinda J, Karunanayake EH (1986) Extra-pancreatic effects of Momordica charantia in rats. J Ethnopharmacol 17(3):247–255
Song F, Chen W, Jia W, Yao P, Nussler AK, Sun X, Liu L (2006) A natural sweetener, Momordica grosvenori, attenuates the imbalance of cellular immune functions in alloxan-induced diabetic mice. Phytother Res 20(7):552–560
Waisundara VY, Hsu A, Huang D, Tan BKH (2008) Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. Am J Chin Med 36(03):517–540
Xi M, Hai C, Tang H, Chen M, Fang K, Liang X (2008) Antioxidant and antiglycation properties of total saponins extracted from traditional Chinese medicine used to treat diabetes mellitus. Phytother Res 22(2):228–237
Resmi CR, Venukumar MR, Latha MS (2006) Antioxidant activity of Albizzia lebbeck (Linn.) Benth. in alloxan diabetic rats. Indian J Physiol Pharmacol 50(3):297
Luo Q, Cai Y, Yan J, Sun M, Corke H (2004) Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum. Life Sci 76(2):137–149
Li XM (2007) Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats. Int J Biol Macromol 40(5):461–465
Wu H, Guo H, Zhao R (2006) Effect of Lycium barbarum polysaccharide on the improvement of antioxidant ability and DNA damage in NIDDM rats. Yakugaku Zasshi 126(5):365–371
Fadzelly AM, Asmah R, Fauziah O (2006) Effects of Strobilanthes crispus tea aqueous extracts on glucose and lipid profile in normal and streptozotocin-induced hyperglycemic rats. Plant Foods Hum Nutr 61(1):6–11
Huseini HF, Larijani B, Heshmat RA, Fakhrzadeh H, Radjabipour B, Toliat T, Raza M (2006) The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type 2 diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Phytother Res 20(12):1036–1039
Xiong S, Melton LD, Easteal AJ, Siew D (2006) Stability and antioxidant activity of black currant anthocyanins in solution and encapsulated in glucan gel. J Agric Food Chem 54(17):6201–6208
Wu FH, Liang JY, Yu P, Cai SF (2005) Studies on the hypoglycemia and lipids regulating effects of Plantago depressa var. montata. Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi China J Chinese materia medica 30(15):1179–1183
Soon YY, Tan BKH (2002) Evaluation of the hypoglycemic and anti-oxidant activities of Morinda officinalis in streptozotocin-induced diabetic rats. Singap Med J 43(2):077–085
Kim HK, Kim MJ, Cho HY, Kim EK, Shin DH (2006) Antioxidative and anti-diabetic effects of amaranth (Amaranthus esculentus) in streptozotocin-induced diabetic rats. Cell Biochem Funct 24(3):195–199
Sezik E, Aslan M, Yesilada E, Ito S (2005) Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay-directed fractionation techniques. Life Sci 76(11):1223–1238
Orhan DD, Aslan M, Aktay G, Ergun E, Yesilada E, Ergun F (2003) Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle. Life Sci 72(20):2273–2283
Xie ZC, Qian ZK, Liu ZW (1993) Effect of ginseng on antiperoxidate injury in myocardium and erythrocytes in streptozocin-induced diabetic rats. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi Chinese J Integr Trad Western Med 13(5):289–290
Anwar MM, Meki ARM (2003) Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin. Comp Biochem Physiol A Mol Integr Physiol 135(4):539–547
Raphael KR, Sabu MC, Kuttan R (2002) Hypoglycemic effect of methanol extract of Phyllanthus amarus Schum & Thonn on alloxan induced diabetes mellitus in rats and its relationship with antioxidant potential. Indian J Exp Biol 40(8):905–909
Patel DK, Prasad SK, Kumar R, Hemalatha S (2012) An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed 2(4):320–330
Feshani AM, Kouhsari SM, Mohammadi S (2011) Vaccinium arctostaphylos, a common herbal medicine in Iran: molecular and biochemical study of its antidiabetic effects on alloxan-diabetic Wistar rats. J Ethnopharmacol 133(1):67–74
Feng CG, Zhang LX, Liu X (2005) Progress in research of aldose reductase inhibitors in traditional medicinal herbs. Zhongguo Zhong yao za zhi Zhongguo zhongyao zazhi China J Chin Materia Medica 30(19):1496–1500
Yoshikawa M, Nishida N, Shimoda H, Takada M, Kawahara Y, Matsuda H (2001) Polyphenol constituents from Salacia species: quantitative analysis of mangiferin with alpha-glucosidase and aldose reductase inhibitory activities. Yakugaku zasshi J Pharmaceut Soc Japan 121(5):371–378
Thakur AK, Shakya A, Husain GM, Emerald M, Kumar V (2014) Gut-microbiota and mental health: current and future perspectives. J Pharmacol Clin Toxicol 2(1):1016
Khin-Maung-U MK, Nyunt-Nyunt-Wai AK (1985) Clinical trial of berberine in acute watery diarrhoea. Br Med J (Clin Res Ed) 291(6509):1601
Rabbani GH, Butler T, Knight J, Sanyal SC, Alam K (1987) Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae. J Infect Dis 155(5):979–984
Tang J, Feng Y, Tsao S, Wang N, Curtain R, Wang Y (2009) Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations. J Ethnopharmacol 126(1):5–17
Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, Ren G (2008) Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metabol 93(7):2559–2565
Zhang X, Zhao Y, Zhang M, Pang X, Xu J, Kang C, Li X (2012) Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats. PLoS One 7(8):e42529
Xu J, Lian F, Zhao L, Zhao Y, Chen X, Zhang X, Pang X (2015) Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula. ISME J 9(3):552
Peluso I, Villaño Valencia D, Chen CYO, Palmery M (2018) Antioxidant, anti-inflammatory, and microbial-modulating activities of nutraceuticals and functional foods. Oxidative Med Cell Longev 2018:1
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Khogta, S., Addepalli, V., Buttar, H.S., Kaur, G. (2019). Potentials of Phytopharmaceuticals for Treating Microbiological and Oxidative Stress-Induced Type 2 Diabetes. In: Chakraborti, S., Chakraborti, T., Chattopadhyay, D., Shaha, C. (eds) Oxidative Stress in Microbial Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-13-8763-0_26
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