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Oxidative Stress and Antioxidants in Host Defense in Leishmaniasis

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Oxidative Stress in Microbial Diseases

Abstract

Leishmaniasis, a tropical neglected disease of the poor and underserved populations, is characterized by skin lesions and ulcers or a clinical pattern of visceral/internal complications which can be lethal. Since innate response is important in hanseniasis, this work reviewed and updated the role of reactive oxygen/nitrogen species in different clinical forms of leishmaniasis (cutaneous, mucocutaneous, and visceral), as well as their role in phagocyte free radicals generators (NADPH-oxidase, iNOS, myeloperoxidase, mitochondrial pathways, and extracellular traps). Knowledge of multiple leishmanial antioxidant responses that can rescue parasites from death and promote resistance to treatment is essential to develop genetic and pharmacologic leishmanicidal strategies.

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  1. Instituto de Ciências Biológicas e da Saúde (ICBS), Campus Universitário do Araguaia, Universidade Federal de Mato Grosso (UFMT), Barra do Garças, MT, Brazil

    Carlos Kusano Bucalen Ferrari

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Correspondence to Carlos Kusano Bucalen Ferrari .

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  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Tapati Chakraborti

  3. Amity University, Kolkata, West Bengal, India

    Dhrubajyoti Chattopadhyay

  4. National Institute of Immunology, New Delhi, India

    Chandrima Shaha

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Ferrari, C.K.B. (2019). Oxidative Stress and Antioxidants in Host Defense in Leishmaniasis. In: Chakraborti, S., Chakraborti, T., Chattopadhyay, D., Shaha, C. (eds) Oxidative Stress in Microbial Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-13-8763-0_13

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