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Genome-Wide Association Studies pp 87–144Cite as

The Association of Single Nucleotide Polymorphisms with Cancer Risk

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Abstract

Cancer is the second leading cause of death and there were 17.5 million cancer cases and 8.7 million deaths worldwide in 2015. Although cancer mortality decreased in the most of countries, cancer cases increased in the most of countries. Recent progress in medical treatment and personalized medicine have significantly improved cancer survival, however prevention and early detection of cancer are the most important approach to reducing cancer mortality. Family history is also associated with a two to fourfold increased risk of cancer in European populations, and 20–40% is expected to be explained by heritable factors. More than 250 studies have identified about 700 significant SNPs. The identification of cancer susceptibility genes contributes to our understanding of disease pathogenesis and risk prediction. Here, we reviewed recent GWAS of prostate, breast, colorectal, lung, liver, gastric, esophageal, bladder, pancreas, ovary, bone, and testicular cancers.

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  1. Laboratory of Clinical genome Sequencing, Department of Computational biology and medical Sciences, Graduate school of Frontier Sciences, The University of Tokyo, Tokyo, Japan

    Koichi Matsuda

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  1. Graduate School of Science, The University of Tokyo, Tokyo, Japan

    Tatsuhiko Tsunoda

  2. BioResource Research Center, Tokyo Medical and Dental University, Tokyo, Japan

    Toshihiro Tanaka

  3. Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan

    Yusuke Nakamura

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Matsuda, K. (2019). The Association of Single Nucleotide Polymorphisms with Cancer Risk. In: Tsunoda, T., Tanaka, T., Nakamura, Y. (eds) Genome-Wide Association Studies. Springer, Singapore. https://doi.org/10.1007/978-981-13-8177-5_5

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