Abstract
Perinatal taurine depletion and high sugar intake from weaning onward worsen cardiac damage and arterial pressure control after ischemia/reperfusion (IR) in adult male and female rats, which can be ameliorated by high taurine diets or inhibition of renin-angiotensin system. This study tests if taurine supplementation ameliorates cardiac damage and arterial pressure control in adult female rats via alterations of both cardiac and systemic renin-angiotensin system. Female Sprague-Dawley rats were fed normal rat chow and drank water alone (control, C) or water containing 3% beta-alanine (taurine depletion, TD) from conception to weaning, and female offspring were subjected to high sugar intake (normal rat chow and 5% glucose in water; CG and TDG) or the normal rat diet (CW and TDW). At 7 weeks of age, half of the rats in each group received 3% taurine in water (CW+T, CG+T, TDW+T, and TDG+T). One week later, rats were subjected to IR or Sham procedures followed by renal nerve recording, plasma and cardiac angiotensin II measurements. Cardiac angiotensin II levels significantly elevated in CG, TDW, and TDG. Further, plasma angiotensin II concentrations were significantly elevated only in the TDG, in consistent with a significant increase in renal nerve activity to juxtaglomerular cells, but not renal vessels and tubules. These abnormalities were ameliorated by short-term taurine supplementation. Thus, in adult female rats that are perinatally depleted of taurine followed by high sugar intake after weaning, taurine supplementation decreases the adverse effects of cardiac IR via inhibition of both cardiac and systemic renin-angiotensin system overactivity.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Abbreviations
- IR:
-
ischemia/reperfusion
- Sham:
-
normal rats without cardiac ischemia/reperfusion induction
- CW:
-
control with water intake alone
- CW+T:
-
control with water intake alone plus taurine
- CG:
-
control with high sugar intake
- CG+T:
-
control with high sugar intake plus taurine
- TDW:
-
perinatal taurine depletion with water intake alone
- TDW+T:
-
perinatal taurine depletion with water intake alone plus taurine
- TDG:
-
perinatal taurine depletion with high sugar intake
- TDG+T:
-
perinatal taurine depletion with high sugar intake plus taurine
References
DiBona GF (2005) Physiology in perspective: the wisdom of the body. Neural control of the kidney. Am J Physiol Regul Integr Comp Physiol 289:R633–R641
Fidler MN et al (2017) Sugar in infants, children and adolescents: a position paper of the European Society for Paediatric Gastroenterology, hepatology and nutrition committee on nutrition. J Pediatr Gastroenterol Nutr 65:681–696
Graham LN, Smith PA, Stoker JB, Mackintosh AF, Mary DA (2002) Time course of sympathetic neural hyperactivity after uncomplicated acute myocardial infarction. Circulation 106:793–797
Hano T, Kasano M, Tomari H, Iwane N (2009) Taurine suppresses pressor response through the inhibition of sympathetic nerve activity and the improvement in baro-reflex sensitivity of spontaneously hypertensive rats. Adv Exp Med Biol 643:57–63
Ito T et al (2010) Cardiac and skeletal muscle abnormality in taurine transporter-knockout mice. J Biomed Sci 17(Suppl 1):S20
Kulthinee S, Wyss JM, Jirakulsomchok D, Roysommuti S (2010) High sugar intake exacerbates cardiac reperfusion injury in perinatal taurine depleted adult rats. J Biomed Sci 17(Suppl 1):S22
Kulthinee S, Wyss JM, Roysommuti S (2015) Taurine supplementation prevents the adverse effect of high sugar intake on arterial pressure control after cardiac ischemia/reperfusion in female rats. Adv Exp Med Biol 803:597–611
Kulthinee S, Rakmanee S, Wyss JM, Roysommuti S (2017) Taurine supplementation ameliorates the adverse effects of perinatal taurine depletion and high sugar intake on cardiac ischemia/reperfusion injury of adult female rats. Adv Exp Med Biol 975:741–755
La Rovere MT, Bigger JT Jr, Marcus FI, Mortara A, Schwartz PJ (1998) Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Lancet 351:478–484
Morrey C, Brazin J, Seyedi N, Corti F, Silver RB, Levi R (2010) Interaction between sensory C-fibers and cardiac mast cells in ischemia/reperfusion: activation of a local renin-angiotensin system culminating in severe arrhythmic dysfunction. J Pharmacol Exp Ther 335:76–84
Okada M, Bunag RD (1994) Insulin acts centrally to enhance reflex tachycardia in conscious rats. Am J Phys 266:R481–R486
Patel AI, Moghadam SD, Freedman M, Hazari A, Fang ML, Allen IE (2018) The association of flavored milk consumption with milk and energy intake, and obesity: a systematic review. Prev Med 111:151–162
Pricher MP, Freeman KL, Brooks VL (2008) Insulin in the brain increases gain of baroreflex control of heart rate and lumbar sympathetic nerve activity. Hypertension 51:514–520
Rakmanee S, Kulthinee S, Wyss JM, Roysommuti S (2017) Taurine supplementation reduces renal nerve activity in male rats in which renal nerve activity was increased by a high sugar diet. Adv Exp Med Biol 975:27–37
Roysommuti S, Wyss JM (2014) Perinatal taurine exposure affects adult arterial pressure control. Amino Acids 46:57–72
Roysommuti S, Wyss JM (2017) Taurine exposure affects cardiac function and disease. In: Watson RR, Zibadi S (eds) Handbook of nutrition in heart health. Wageningen Academic Publishers, Wageningen, pp 231–247
Schaffer SW, Lombardini JB, Azuma J (2000) Interaction between the actions of taurine and angiotensin II. Amino Acids 18:305–318
Schaffer SW, Jong CJ, Ito T, Azuma J (2014) Effect of taurine on ischemia-reperfusion injury. Amino Acids 46:21–30
Acknowledgements
This study was supported by grants from Faculty of Medicine and Graduate School, Khon Kaen University, Khon Kaen 40002, Thailand.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this paper
Cite this paper
Kulthinee, S., Wyss, J.M., Roysommuti, S. (2019). Taurine Supplementation Inhibits Cardiac and Systemic Renin-Angiotensin System Overactivity After Cardiac Ischemia/Reperfusion in Adult Female Rats Perinatally Depleted of Taurine Followed by High Sugar Intake. In: Hu, J., Piao, F., Schaffer, S., El Idrissi, A., Wu, JY. (eds) Taurine 11. Advances in Experimental Medicine and Biology, vol 1155. Springer, Singapore. https://doi.org/10.1007/978-981-13-8023-5_9
Download citation
DOI: https://doi.org/10.1007/978-981-13-8023-5_9
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-8022-8
Online ISBN: 978-981-13-8023-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)