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Influences of Taurine Deficiency on Bile Acids of the Bile in the Cat Model

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 1155)


Taurine content in the body is maintained by both biosynthesis from sulfur-contained amino acids in the liver and ingestion from usual foods, mainly seafoods and meat. Contrary to the rodents, the maintenance of taurine content in the body depends on the oral taurine ingestion in cats as well as humans because of the low ability of the biosynthesis. Therefore, insufficient of dietary taurine intake increases the risks of various diseases such as blind and expanded cardiomyopathy in the cats. One of the most established physiological roles of taurine is the conjugation with bile acid in the liver. In addition, taurine has effect to increase the expression and activity of bile acid synthesis rate-limiting enzyme CYP7A1. Present study purposed to evaluate the influence of taurine deficiency on bile acids in the cats fed taurine-lacking diet. Adult cats were fed the soybean protein-based diet with 0.15% taurine or without taurine for 30 weeks. Taurine concentration in serum and liver was undetectable, and bile acids in the bile were significantly decreased in the taurine-deficient cats. Taurine-conjugated bile acids in the bile were significantly decreased, and instead, unconjugated bile acids were significantly increased in the taurine-deficient cats. Present results suggested that the taurine may play an important role in the synthesis of bile acids in the liver.


  • Bile acid
  • Cats
  • LC-MS/MS
  • Liver
  • Taurine deficiency

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  • DOI: 10.1007/978-981-13-8023-5_4
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Fig. 1



3-aminopyridyl-N-hydroxysuccinimidyl carbamate


ATP-dependent microsomal bile acid-CoA synthetase


bile acid-CoA:amino acid N-acetyltransferase


body weight


cholic acid


chenodeoxycholic acid


cysteine dioxygenase


cysteine sulfinate decarboxylase


cytochrome P450 7a1


deoxycholic acid


days in age


electrospray ionization


farnesoid X receptor


glycocholic acid


glycochenodeoxycholic acid


glycodeoxycholic acid


glycolithocholic acid


glycoursodeoxycholic acid


hyodeoxycholic acid


lithocholic acid


muricholic acid


selected reaction monitoring


taurocholic acid


taurochenodeoxycholic acid


taurodeoxycholic acid


taurolithocholic acid


tauroursodeoxycholic acid


ursodeoxycholic acid


ultra-fast liquid chromatography


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This research was supported in part by an Ibaraki University Cooperation between Agriculture and Medical Science (IUCAM) (Ministry of Education, Culture, Sports, Science and Technology, Japan).

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Correspondence to Teruo Miyazaki .

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Miyazaki, T. et al. (2019). Influences of Taurine Deficiency on Bile Acids of the Bile in the Cat Model. In: Hu, J., Piao, F., Schaffer, S., El Idrissi, A., Wu, JY. (eds) Taurine 11. Advances in Experimental Medicine and Biology, vol 1155. Springer, Singapore.

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