Abstract
We previously reported that taurine treatment inhibited arsenic (As)-induced apoptosis in the liver of mice. This study was designed to explore the effect of taurine on liver function and its underlying mechanism in As-exposed mice. Mice were randomly divided into 3 groups, ten mice in each group. Group 1, control group, only orally received drinking water alone. Group 2, As intoxication group, was exposed to 4 mg/L As2O3 via drinking water for 60 days. Group 3, taurine protection group, was treated with 4 mg/L As2O3 and 150 mg/kg both. Taurine administration significantly revered the increases of alanine transaminase (ALT) and aspartate transaminase (AST) activities in serum. The decrease of glutathione (GSH) was inhibited with taurine treatment in the liver of As-exposed mice. At the same time, taurine significantly inhihibited As-induced enhancement of malondialdehyde (MDA) in the liver. Here we show that taurine protective effect on liver function in As-exposed mice maybe involve lipid peroxidation.
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- ALT:
-
alanine transaminase
- As:
-
arsenic
- AST:
-
aspartate transaminase
- GSH:
-
glutathione
- MDA:
-
malondialdehyde
References
Anwar-Mohamed A, Abdelhamid G, Amara IE, El-Kadi AO (2012) Differential modulation of aryl hydrocarbon receptor regulated enzymes by arsenite in the kidney, lung, and heart of C57BL/6 mice. Arch Toxicol 86:897–910
Ayala-Fierro F, Barber DS, Rael LT, Carter DE (1999) In vitro tissue specificity for arsine and arsenite toxicity in the rat. Toxicol Sci 52:122–129
Bardach AE, Ciapponi A, Soto N, Chaparro MR, Calderon M, Briatore A, Cadoppi N, Tassara R, Litter MI (2015) Epidemiology of chronic disease related to arsenic in Argentina: a systematic review. Sci Total Environ 538:802–816
Batista TM, Ribeiro RA, da Silva PM, Camargo RL, Lollo PC, Boschero AC, Carneiro EM (2013) Taurine supplementation improves liver glucose control in normal protein and malnourished mice fed a high-fat diet. Mol Nutr Food Res 57:423–434
Benbrahim-Tallaa L, Waterland RA, Styblo M, Achanzar WE, Webber MM, Waalkes MP (2005) Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation. Toxicol Appl Pharmacol 206:288–298
Bosgelmez II, Soylemezoglu T, Guvendik G (2008) The protective and antidotal effects of taurine on hexavalent chromium-induced oxidative stress in mice liver tissue. Biol Trace Elem Res 125:46–58
Budhram R, Pandya KG, Lau-Cam CA (2013) Protection by taurine and thiotaurine against biochemical and cellular alterations induced by diabetes in a rat model. Adv Exp Med Biol 775:321–343
Chen B, Arnold LL, Cohen SM, Thomas DJ, Le XC (2011) Mouse arsenic (+3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water. Toxicol Sci 124:320–326
Das J, Ghosh J, Manna P, Sil PC (2010) Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway. PLoS One 5:e12602
Das J, Roy A, Sil PC (2012) Mechanism of the protective action of taurine in toxin and drug induced organ pathophysiology and diabetic complications: a review. Food Funct 3:1251–1264
Gao S, Duan X, Wang X, Dong D, Liu D, Li X, Sun G, Li B (2013) Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Food Chem Toxicol 59:739–747
Heidari R, Babaei H, Eghbal MA (2014) Amodiaquine-induced toxicity in isolated rat hepatocytes and the cytoprotective effects of taurine and/or N-acetyl cysteine. Res Pharm Sci 9:97–105
Higuchi M, Celino FT, Shimizu-Yamaguchi S, Miura C, Miura T (2012) Taurine plays an important role in the protection of spermatogonia from oxidative stress. Amino Acids 43:2359–2369
Hwang DF, Wang LC (2001) Effect of taurine on toxicity of cadmium in rats. Toxicology 167:173–180
Hwang DF, Wang LC, Cheng HM (1998) Effect of taurine on toxicity of copper in rats. Food Chem Toxicol 36:239–244
Jain A, Yadav A, Bozhkov AI, Padalko VI, Flora SJ (2011) Therapeutic efficacy of silymarin and naringenin in reducing arsenic-induced hepatic damage in young rats. Ecotoxicol Environ Saf 74:607–614
Li S, Yang L, Dong G, Wang X (2017) Taurine protects mouse liver against arsenic-induced apoptosis through JNK pathway. Adv Exp Med Biol 975:855–862
Mathew L, Vale A, Adcock JE (2010) Arsenical peripheral neuropathy. Pract Neurol 10:34–38
Meliker JR, Wahl RL, Cameron LL, Nriagu JO (2007) Arsenic in drinking water and cerebrovascular disease, diabetes mellitus, and kidney disease in Michigan: a standardized mortality ratio analysis. Environ Health 6:4
Mershiba SD, Dassprakash MV, Saraswathy SD (2013) Protective effect of naringenin on hepatic and renal dysfunction and oxidative stress in arsenic intoxicated rats. Mol Biol Rep 40:3681–3691
Messarah M, Klibet F, Boumendjel A, Abdennour C, Bouzerna N, Boulakoud MS, El Feki A (2012) Hepatoprotective role and antioxidant capacity of selenium on arsenic-induced liver injury in rats. Exp Toxicol Pathol 64:167–174
Patrick L (2006) Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Altern Med Rev 11:114–127
Rodriguez-Lado L, Sun G, Berg M, Zhang Q, Xue H, Zheng Q, Johnson CA (2013) Groundwater arsenic contamination throughout China. Science 341:866–868
Tabassum H, Rehman H, Banerjee BD, Raisuddin S, Parvez S (2006) Attenuation of tamoxifen-induced hepatotoxicity by taurine in mice. Clin Chim Acta 370:129–136
Warskulat U, Borsch E, Reinehr R, Heller-Stilb B, Monnighoff I, Buchczyk D, Donner M, Flogel U, Kappert G, Soboll S, Beer S, Pfeffer K, Marschall HU, Gabrielsen M, Amiry-Moghaddam M, Ottersen OP, Dienes HP, Haussinger D (2006) Chronic liver disease is triggered by taurine transporter knockout in the mouse. FASEB J 20:574–576
Warskulat U, Borsch E, Reinehr R, Heller-Stilb B, Roth C, Witt M, Haussinger D (2007) Taurine deficiency and apoptosis: findings from the taurine transporter knockout mouse. Arch Biochem Biophys 462:202–209
Zhang Z, Liu D, Yi B, Liao Z, Tang L, Yin D, He M (2014) Taurine supplementation reduces oxidative stress and protects the liver in an iron-overload murine model. Mol Med Rep 10:2255–2262
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Li, S., Wei, B.K., Wang, J., Dong, G., Wang, X. (2019). Taurine Supplementation Ameliorates Arsenic-Induced Hepatotoxicity and Oxidative Stress in Mouse. In: Hu, J., Piao, F., Schaffer, S., El Idrissi, A., Wu, JY. (eds) Taurine 11. Advances in Experimental Medicine and Biology, vol 1155. Springer, Singapore. https://doi.org/10.1007/978-981-13-8023-5_43
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DOI: https://doi.org/10.1007/978-981-13-8023-5_43
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