Functionalized Silk for Surgical Suture Applications

Conference paper


In the present state of environmental consciousness, the modern quality necessities of a product not only stress on the inherent functionality but also a preparation method that is ecological. Hence, investigations on coating agents based on natural extracts for medical and healthcare textiles application are gaining global attention. In this work, a novel attempt has been made to coat the silk sutures with natural bioactive agents such as aloe vera, curcumin, and chitosan. The exhaustion method was adopted for the application of extracts in two different combinations, aloe vera, curcumin, and aloe vera, curcumin in combination with chitosan. Suture properties such as tenacity, knot strength, coefficient of friction, and antimicrobial property were tested. The process variables such as time, temperature, and concentration were optimized for better performance of the sutures by adopting the Box–Behnken response surface methodology. Sutures treated with aloe vera and curcumin in combination with chitosan had low values of coefficient of friction, i.e., 0.199 and maximum values of tenacity and knot strength of 39.86cN/tex and 30.56 cN/tex, respectively. The silk sutures treated with aloe vera and curcumin in combination with chitosan, under the optimized conditions exhibited a zone of inhibition of 6 mm for Staphylococcus aureus and 4 mm for Escherichia coli bacteria.


Silk Suture Tenacity 



One of the author Dr. S. Viju has been granted Career Award for Young Teachers (CAYT) by All India Council for Technical Education (AICTE), Government of India under Project Number [F.No.11-36/RIFD/CAYT/POL-1/2014-15]. The financial support received from AICTE for carrying out this work is gratefully acknowledged.


  1. 1.
    Pillai, C.K.S., Sharma, C.P.: Review paper: absorbable polymeric surgical sutures: chemistry, production, properties, biodegradability, and performance. J. Biomater. Appl. 25(4), 291–366 (2010)CrossRefGoogle Scholar
  2. 2.
    Viju, S., Thilagavathi, G.: Fabrication and characterization of silk braided sutures. Fiber Polym. 13(6), 782–789 (2012)CrossRefGoogle Scholar
  3. 3.
    Viju, S., Thilagavathi, G.: Effect of chitosan coating on the characteristics of silk-braided sutures. J. Ind. Text. 42(3), 256–268 (2012)CrossRefGoogle Scholar
  4. 4.
    Aiello, A.E., Clayton, E.M.R., Todd, M., Dowd, J.B.: The Impact of Bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006. Environ. Health Perspect. 119(3), 390–396 (2011)Google Scholar
  5. 5.
    Sudha, D., Dhurai, B., Ponthangam, T.: Development of herbal drug loaded antimicrobial silk suture. Ind. J. Fibre Text Res. 42, 286–290 (2017)Google Scholar
  6. 6.
    Parthiban, M., Thilagavathi, G., Viju, S.: Development of antibacterial silk sutures using natural fungal extract for healthcare applications. J. Text. Sci. Eng. 6, 249 (2016). Scholar
  7. 7.
    Pethile, S., Chen, X.J., Hou, D., Wang, L.: Effect of changing coating process parameters in the preparation of antimicrobial-coated silk sutures: an in vitro study. Fibers Polym. 15(8), 1589–1595 (2014). Scholar
  8. 8.
    Chen, X., Hou, D., Tang, X., Wang, L.: Quantitative physical and handling characteristics of novel antibacterial braided silk suture materials. J. Mech. Behav. Biomed. Mater. 50, 160–170 (2015)CrossRefGoogle Scholar
  9. 9.
    Tummalapalli, M., Anjum, S., Kumari, S., Gupta, B.: Antimicrobial surgical sutures: recent developments and strategies. Polym. Rev. 1–24(2016). Scholar
  10. 10.
    Ammayappan, L., Jeyakodi Moses, J.: Study of antimicrobial activity of aloevera, chitosan, and curcumin on cotton, wool, and rabbit hair. Fiber Polym. 10(2), 161–166 (2009)CrossRefGoogle Scholar
  11. 11.
  12. 12.
    Agarry, O.O., Olaleye, M.T., Michael, C.O.B.: Comparative antimicrobial activities of aloe vera gel and leaf. Afr. J. Biotech. 12, 1413 (2005)Google Scholar
  13. 13.
    Liu, X.F., Guan, Y.L., Yang, D.Z., Yao, K.D.: Antibacterial action of chitosan and carboxymethylated chitosan. J. Appl. Polym. Sci. 79, 1324 (2001). Scholar
  14. 14.
    MahendraGowda, R.V., Mohanraj, S.: A novel approach to measure friction in textile fibre assemblies. Res. J. Text. Apparel. 12(2), 30–38 (2008)CrossRefGoogle Scholar
  15. 15.
    Ben Abdessalem, S., Debbai, F., Jedda, H., Elmarzougui, S., Mokhtar, S.: Tensile and knot performance of polyester braided sutures. Text. Res. J. 79(3), 247–252 (2009)CrossRefGoogle Scholar
  16. 16.
    Viju, S.: Development and characterisation of silk and Poly L-lactic acid based sutures. Ph.D. thesis, PSG College of Technology, Anna University Chennai, Tamilnadu, India (2013)Google Scholar
  17. 17.
    Kavitha, T., Padmashini, R., Swarna, A., Gridev, V.R., Neelakandan, R., Senthilkumar, M.: Effect of chitosan treatment on the properties of turmeric dyed cotton yarn. Ind. J. Fibre Text. Res. 32(1), 53–56 (2007)Google Scholar
  18. 18.
    Heward, A.G., Laing, R.M., Carr, D.J., Niven, B.E.: Tensile performance on nonsterile suture monofilaments affected by test conditions. Text. Res. J. 74(1), 83–90 (2004)CrossRefGoogle Scholar
  19. 19.
    Ammayappan, L., Jeyakodi Moses, J.: Study of antimicrobial activity of aloevera, chitosan, and curcumin on cotton, wool, and rabbit hair. Fibers Polym. 10(2), 161–166 (2009)CrossRefGoogle Scholar
  20. 20.
    Goy, R.C., Assis, O.B.G.: Antimicrobial Analysis of Films Processed from Chitosan and N,N,N-Trimethylchitosan. Brazilian J. Chem. Eng. 31(3), 51–56 (2014)CrossRefGoogle Scholar

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Textile TechnologyPSG College of TechnologyCoimbatoreIndia

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